Phospholipase C γ1 regulates early secretory trafficking and cell migration via interaction with p115.

scientific article published on 22 April 2015

Phospholipase C γ1 regulates early secretory trafficking and cell migration via interaction with p115. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E15-03-0178
P932PMC publication ID4462944
P698PubMed publication ID25904324
P5875ResearchGate publication ID275359013

P50authorFranck PerezQ41498124
Gaelle BoncompainQ54447261
Hesso FarhanQ58757936
P2093author name stringElizabeth Sztul
Valentina Millarte
Kerstin Tillmann
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GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote buddingQ24336708
The membrane transport factor TAP/p115 cycles between the Golgi and earlier secretory compartments and contains distinct domains required for its localization and function.Q24682925
Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathwayQ27315034
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An SH3 domain is required for the mitogenic activity of microinjected phospholipase C-gamma 1.Q30193704
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MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screeningQ33916063
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A highly dynamic ER-derived phosphatidylinositol-synthesizing organelle supplies phosphoinositides to cellular membranesQ35607232
phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial developmentQ35965422
The KDEL receptor couples to Gαq/11 to activate Src kinases and regulate transport through the GolgiQ36090299
Polarization of the Golgi apparatus and the microtubule-organizing center in cultured fibroblasts at the edge of an experimental woundQ36292185
Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulationQ36322541
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RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cellsQ36524969
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TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells.Q36887004
The regulation of cell motility and chemotaxis by phospholipid signalingQ37089555
A primary role for Golgi positioning in directed secretion, cell polarity, and wound healingQ37127268
Role of phospholipase C in cell invasion and metastasisQ38127322
ER to Golgi transport: Requirement for p115 at a pre-Golgi VTC stageQ38317438
Systems biology of the secretory pathway: what have we learned so far?Q38372024
RNAi screens for genes involved in Golgi glycosylationQ38907373
Regulation of Sec16 levels and dynamics links proliferation and secretionQ38926875
Control systems of membrane transport at the interface between the endoplasmic reticulum and the GolgiQ38966653
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxisQ39386624
Identification of genes that regulate epithelial cell migration using an siRNA screening approachQ39892281
A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway.Q39959122
Functional genomics reveals genes involved in protein secretion and Golgi organizationQ40321794
Identification, by a monoclonal antibody, of a 53-kD protein associated with a tubulo-vesicular compartment at the cis-side of the Golgi apparatusQ41563890
Systematic analysis of RNAi reports identifies dismal commonality at gene-level and reveals an unprecedented enrichment in pooled shRNA screensQ41860715
ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65.Q42425987
Phospholipase C-gamma1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activationQ42827941
Lithium Effects on Inositol Phospholipids and Inositol Phosphates: Evaluation of an In Vivo Model for Assessing Polyphosphoinositide Turnover in BrainQ43943459
Live imaging of bidirectional traffic from the ERGIC.Q45345739
PLCgamma1 is essential for early events in integrin signalling required for cell motilityQ46535556
Synchronization of secretory protein traffic in populations of cells.Q50501044
Systems survey of endocytosis by multiparametric image analysis.Q51913883
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathwayQ56990540
Systems biology: evolving into the mainstreamQ83636885
P4510describes a project that usesImageJQ1659584
P433issue12
P304page(s)2263-2278
P577publication date2015-04-22
P1433published inMolecular Biology of the CellQ2338259
P1476titlePhospholipase C γ1 regulates early secretory trafficking and cell migration via interaction with p115.
P478volume26

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cites work (P2860)
Q36271856Alteration of Golgi Structure by Stress: A Link to Neurodegeneration?
Q39241478Antagonistic roles for STYX pseudophosphatases in neurite outgrowth
Q36734480Cdc42 and Cellular Polarity: Emerging Roles at the Golgi
Q39178793Crosstalk of cell polarity signaling pathways.
Q45945058Digging deep into Golgi phenotypic diversity with unsupervised machine learning.
Q92715770Epistatic Analysis of the Contribution of Rabs and Kifs to CATCHR Family Dependent Golgi Organization
Q30832460GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge
Q92111180Golgi Dynamics: The Morphology of the Mammalian Golgi Apparatus in Health and Disease
Q41893637TGF-β1 signaling pathway serves a role in HepG2 cell regulation by affecting the protein expression of PCNA, gankyrin, p115, XIAP and survivin
Q90584259Vesicle trafficking pathways that direct cell migration in 3D matrices and in vivo

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