PNPLA3 genetic variation in alcoholic steatosis and liver disease progression

scientific article published on June 2015

PNPLA3 genetic variation in alcoholic steatosis and liver disease progression is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3978/J.ISSN.2304-3881.2014.11.04
P932PMC publication ID4465608
P698PubMed publication ID26151055
P5875ResearchGate publication ID272073465

P50authorJochen HampeQ30348904
Stefano RomeoQ56936985
P2093author name stringFelix Stickel
Christian Datz
Eric Trépo
P2860cites workIdentification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activitiesQ24303914
PNPLA3 mediates hepatocyte triacylglycerol remodelingQ24336530
The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyadQ27641368
EASL-EORTC clinical practice guidelines: management of hepatocellular carcinomaQ27860783
Plasma retinol binding protein: structure and function of the prototypic lipocalinQ28142676
Characterization of the human patatin-like phospholipase familyQ28248355
Hepatocellular carcinoma in cirrhosis: incidence and risk factorsQ28290048
In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cellsQ28609128
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseQ29614897
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liverQ29616840
Association between the PNPLA3 (rs738409 C>G) variant and hepatocellular carcinoma: Evidence from a meta-analysis of individual participant dataQ30675355
A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysisQ33673834
The assembly and secretion of apolipoprotein B-containing lipoproteinsQ33730869
Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver diseaseQ33777486
A feed-forward loop amplifies nutritional regulation of PNPLA3Q33842841
PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cellsQ33847621
The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosisQ34075498
Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver diseaseQ34101705
A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitisQ34140192
Sex difference in alcohol-related organ injury.Q34272755
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variantQ34314416
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndromeQ34503398
Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosisQ34675058
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymesQ34861754
Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver diseaseQ35423296
Knowledge of hepatocellular carcinoma screening guidelines and clinical practices among gastroenterologistsQ36349931
Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosisQ36357941
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in ratsQ36684364
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetesQ36698641
Lipoproteins and Lipid TransportQ36742106
Molecular mechanisms of alcohol-mediated carcinogenesisQ36889966
Genetic determinants of alcoholic liver diseaseQ37959931
Global burden of alcoholic liver diseasesQ38091294
Systematic review with meta-analysis: the I148M variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is significantly associated with alcoholic liver cirrhosis.Q38233721
PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysisQ39396087
Chemical structure and the changing concept of vitamin A activityQ40134068
Biochemical mechanisms of vitamin A actionQ40146792
The critical dimension of ethnicity in liver cirrhosis mortality statisticsQ40691541
Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma.Q42232935
Genetic predisposition to organ-specific endpoints of alcoholismQ42647637
The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.Q43024330
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.Q43107476
Variant in PNPLA3 is associated with alcoholic liver diseaseQ43234008
PNPLA3 rs738409, hepatocellular carcinoma occurrence and risk model prediction in patients with cirrhosis.Q43611915
Mouse patatin-like phospholipase domain-containing 3 influences systemic lipid and glucose homeostasisQ43804565
Genetic factors affecting susceptibility to alcoholic liver disease in an Indian populationQ44156776
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humansQ44602540
Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of functionQ44619799
PNPLA3 (rs738409 C>G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis.Q44635062
PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individualsQ44985440
Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veteransQ45337618
Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver diseaseQ45713646
A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humansQ46118770
PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrence.Q51439752
Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasiansQ58097689
Patatin-like phospholipase domain containing 3: A case in point linking genetic susceptibility for alcoholic and nonalcoholic liver diseaseQ63241925
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitroQ63408528
Hepatic retinol metabolism. Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cellsQ70105966
Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liverQ71520059
Hepatosteatosis with hypobetalipoproteinemiaQ80061442
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectgenetic variationQ349856
liver diseaseQ929737
steatosisQ1365091
P304page(s)152-160
P577publication date2015-06-01
P1433published inHepatobiliary surgery and nutritionQ26842328
P1476titlePNPLA3 genetic variation in alcoholic steatosis and liver disease progression
P478volume4

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cites work (P2860)
Q60912314A two gene-based risk score predicts alcoholic cirrhosis development in males with at-risk alcohol consumption
Q47115217AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M.
Q39256297Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation
Q90135434PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
Q37513088Primary liver injury and delayed resolution of liver stiffness after alcohol detoxification in heavy drinkers with the PNPLA3 variant I148M.
Q46067368Reassessment of different criteria for diagnosing post-hepatectomy liver failure: a single-center study of 1683 hepatectomy
Q28831365Short-Term Hypocaloric High-Fiber and High-Protein Diet Improves Hepatic Steatosis Assessed by Controlled Attenuation Parameter