Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle

scientific article published on December 2011

Insights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/CC.10.23.18501
P932PMC publication ID3272283
P698PubMed publication ID22101265
P5875ResearchGate publication ID51815503

P2093author name stringTony T Huang
Mathew J K Jones
Xiomaris M Cotto-Rios
P2860cites workE2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)Q24296663
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitorQ24300354
Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cellsQ24302543
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathwayQ24303605
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entryQ24303864
FANCI is a second monoubiquitinated member of the Fanconi anemia pathwayQ24303906
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphaseQ24304123
Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressQ24307983
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpointQ24317772
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrityQ37799221
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stressQ39593027
A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivoQ39716146
Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.Q39847635
Ubiquitination and deubiquitination of PCNA in response to stalling of the replication forkQ39883218
Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.Q40079322
Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.Q40261081
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry.Q40488999
ID4: a new player in the cancer arenaQ40580196
Roscovitine, a cyclin-dependent kinase inhibitor, prevents replication of varicella-zoster virusQ40584589
Deubiquitination of FANCD2 is required for DNA crosslink repairQ41770119
Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosisQ41868466
Cdh1: a master G0/G1 regulator.Q42090275
Hiding human thymidine kinase 1 from APC/C-mediated destruction by thymidine bindingQ42831988
The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and timeQ42917794
APC/CCdh1 specific degradation of Hsl1 and Clb2 is required for proper stress responses of S. cerevisiae.Q43284500
Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1.Q46953383
Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex.Q52103792
Genomic stability and tumour suppression by the APC/C cofactor Cdh1.Q53471624
Identification of the Fanconi anemia complementation group I gene, FANCI.Q54858556
Degradation of human Aurora-A protein kinase is mediated by hCdh1Q74144066
Functional sites of human PCNA which interact with p21 (Cip1/Waf1), DNA polymerase delta and replication factor CQ77291997
UAF1 is a subunit of multiple deubiquitinating enzyme complexesQ24329003
Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1Q24600785
PHOSIDA 2011: the posttranslational modification databaseQ24611418
How the fanconi anemia pathway guards the genomeQ24634556
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymesQ24645701
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repairQ24685928
Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.Q27930227
CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.Q27930914
Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complexQ27933305
Regulation of monoubiquitinated PCNA by DUB autocleavageQ28115531
Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1Q28282074
Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteinsQ28343954
USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcomaQ28594596
Dual regulation of the anaphase promoting complex in human cells by cyclin A-Cdk2 and cyclin A-Cdk1 complexesQ28610308
Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpointQ28631721
Stabilizers and Destabilizers Controlling Cell Cycle OscillatorsQ29028448
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNAQ29615251
PhosphoSite: A bioinformatics resource dedicated to physiological protein phosphorylationQ29615970
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathwayQ29616746
Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting propertyQ33836931
New insights into the formation and resolution of ultra-fine anaphase bridgesQ34202945
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysisQ34449803
Replication stress induces 53BP1-containing OPT domains in G1 cellsQ34854577
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalitiesQ34982804
Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.Q35099193
APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.Q35130203
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzymeQ35739744
Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exitQ35787361
Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathwayQ36222297
Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1Q36489137
Translesion synthesis in mammalian cellsQ36541050
State of the APC/C: organization, function, and structureQ36867692
The p21 and PCNA partnership: a new twist for an old plotQ37344585
Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response.Q37680260
P433issue23
P921main subjectphosphorylationQ242736
P1104number of pages8
P304page(s)4009-4016
P577publication date2011-12-01
P1433published inCell CycleQ1254166
P1476titleInsights into phosphorylation-dependent mechanisms regulating USP1 protein stability during the cell cycle
P478volume10

Reverse relations

cites work (P2860)
Q37324515A novel role for the deubiquitinase USP1 in the control of centrosome duplication
Q90069484An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases
Q30416136CAPNS1 regulates USP1 stability and maintenance of genome integrity
Q38336126DUBs, the regulation of cell identity and disease
Q27026189Deubiquitinating enzymes as oncotargets
Q39301938Eukaryotic Translesion DNA Synthesis on the Leading and Lagging Strands: Unique Detours around the Same Obstacle
Q38822748Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future
Q36743136Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1.
Q41285125Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage.
Q38022544The Fanconi anemia pathway in replication stress and DNA crosslink repair.
Q37496493The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention
Q37467664The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway
Q58592810USP1 (ubiquitin specific peptidase 1) targets ULK1 and regulates its cellular compartmentalization and autophagy
Q38128426USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.
Q90059126USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation

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