Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

scientific article published on 12 January 2012

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1101/GAD.177758.111
P932PMC publication ID3273835
P698PubMed publication ID22241783
P5875ResearchGate publication ID221744474

P2093author name stringAlexander Tarakhovsky
Brian T Chait
Steffen Just
Wolfgang A Linke
Wolfgang Rottbauer
Carol C Gregorio
Anke Zieseniss
Andreas Unger
Marc-Werner Dobenecker
Christopher T Pappas
Laura T Donlin
Christian Andresen
Martina Kruger
Erica Y Jacobs
Eugene Rudensky
Tobias Voelkel
P2860cites workGenome-wide survey and developmental expression mapping of zebrafish SET domain-containing genesQ21562301
Translating the Histone CodeQ22065840
Methylation of the retinoblastoma tumor suppressor by SMYD2Q24300912
Regulation of p53 activity through lysine methylationQ24311514
Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signalingQ24312041
Titins: giant proteins in charge of muscle ultrastructure and elasticityQ24312140
Repression of p53 activity by Smyd2-mediated methylationQ24315991
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunitQ24317508
Smyd3 is required for the development of cardiac and skeletal muscle in zebrafishQ27324280
Chromatin modifications and their functionQ27861067
A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in developmentQ28473399
Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complexQ28505248
Cardiac deletion of Smyd2 is dispensable for mouse heart developmentQ28579709
Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesisQ28587459
The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesisQ28754755
Histone methylation versus histone acetylation: new insights into epigenetic regulationQ30307367
Heat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos.Q30481082
Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryosQ33521901
Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.Q33591456
The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding siteQ34335956
SmyD1, a histone methyltransferase, is required for myofibril organization and muscle contraction in zebrafish embryos.Q34928212
Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domainQ35214628
The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M lineQ36218609
Mechanisms of thin filament assembly in embryonic chick cardiac myocytes: tropomodulin requires tropomyosin for assembly.Q36235536
I-band titin in cardiac muscle is a three-element molecular spring and is critical for maintaining thin filament structureQ36293292
Is there a code embedded in proteins that is based on post-translational modifications?Q37266141
Regulation of NF-kappaB activity through lysine monomethylation of p65.Q37404711
Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assemblyQ40091979
Role of the myosin assembly protein UNC-45 as a molecular chaperone for myosinQ40754906
smyd1 and smyd2 are expressed in muscle tissue in Xenopus laevisQ42084794
Titin isoform switch in ischemic human heart disease.Q44131316
In vivo methylation and turnover of rat brain histonesQ48526775
Polycomb group protein ezh2 controls actin polymerization and cell signaling.Q53676862
Reverse engineering of the giant muscle protein titinQ59085863
The distribution and turnover of labeled methyl groups in histone fractions of cultured mammalian cellsQ70456628
Antisense suppression of skeletal muscle myosin light chain-1 biosynthesis impairs myofibrillogenesis in cultured myotubesQ72239621
Differential expression of cardiac titin isoforms and modulation of cellular stiffnessQ73333652
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectSET and MYND domain containing 2bQ29833509
SET and MYND domain containing 2aQ29834328
P304page(s)114-119
P577publication date2012-01-12
P1433published inGenes & DevelopmentQ1524533
P1476titleSmyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization
P478volume26

Reverse relations

cites work (P2860)
Q90091087A methylated lysine is a switch point for conformational communication in the chaperone Hsp90
Q30179453A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity
Q38224878A rising titan: TTN review and mutation update
Q59135042An insight into new strategies to combat antifungal drug resistance
Q26864659An unexpected journey: lysine methylation across the proteome
Q35818709Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation
Q61829990Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer
Q103001780Cell geometry and the cytoskeleton impact the nucleo-cytoplasmic localisation of the SMYD3 methyltransferase
Q99708572Cells of the adult human heart
Q86063319Changes in gene expression and content of Hsp70 and Hsp90 in striated muscles of mice after 30-day space flight on the biosatellite Bion-M1
Q47260941Chaperones and the Proteasome System: Regulating the Construction and Demolition of Striated Muscle
Q26999888Chromatin targeting drugs in cancer and immunity
Q35051327Circles within circles: crosstalk between protein Ser/Thr/Tyr-phosphorylation and Met oxidation
Q36783008Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer
Q28829391Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2
Q37350604Disruptive influence.
Q38557842Emerging roles of lysine methylation on non-histone proteins
Q28645901Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species
Q36833415Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication
Q38584468HSP90AB1: Helping the good and the bad.
Q42845134Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease
Q92348528Histone methyltransferase SMYD2: ubiquitous regulator of disease
Q45966440Host Methyltransferases and Demethylases: Potential New Epigenetic Targets for HIV Cure Strategies and Beyond.
Q37498583Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins
Q39078089Immunoaffinity enrichment and mass spectrometry analysis of protein methylation
Q43125363Isoform composition and gene expression of thick and thin filament proteins in striated muscles of mice after 30-day space flight
Q36138616JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis
Q28084876KDM1 class flavin-dependent protein lysine demethylases
Q37696865Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis
Q35662225LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2.
Q37089501Large-scale global identification of protein lysine methylation in vivo
Q41616035Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis
Q38266428Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.
Q34150501Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis
Q99233826Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin
Q64261976Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues
Q36802641Mouse myofibers lacking the SMYD1 methyltransferase are susceptible to atrophy, internalization of nuclei and myofibrillar disarray
Q22065593Nonhuman genetics. Genomic basis for the convergent evolution of electric organs
Q57464468Overexpression of SET and MYND Domain-Containing Protein 2 (SMYD2) Is Associated with Tumor Progression and Poor Prognosis in Patients with Papillary Thyroid Carcinoma
Q51752072Progress and prospects for targeting Hsp90 to treat fungal infections.
Q48223158Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes.
Q36745154Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics
Q36480321Reduced passive force in skeletal muscles lacking protein arginylation
Q38086397Regulation of molecular chaperones through post-translational modifications: decrypting the chaperone code
Q37615671SET for life: biochemical activities and biological functions of SET domain-containing proteins
Q37364870SMYD proteins in immunity: dawning of a new era.
Q26865167SMYD proteins: key regulators in skeletal and cardiac muscle development and function
Q58600320SMYD2 glutathionylation contributes to degradation of sarcomeric proteins
Q42293531SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress
Q28542486Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase
Q91635522Single-Molecule Force Spectroscopy on the N2A Element of Titin: Effects of Phosphorylation and CARP
Q37306191Smyd1b is required for skeletal and cardiac muscle function in zebrafish
Q37686995Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.
Q41965903Smyd5 plays pivotal roles in both primitive and definitive hematopoiesis during zebrafish embryogenesis
Q36257819Still Heart Encodes a Structural HMT, SMYD1b, with Chaperone-Like Function during Fast Muscle Sarcomere Assembly
Q98771670Structural Paradigms in the Recognition of the Nucleosome Core Particle by Histone Lysine Methyltransferases
Q33606391The "histone mimicry" by pathogens
Q35839970The Effects of Hsp90α1 Mutations on Myosin Thick Filament Organization
Q91386356The SMYD3 methyltransferase promotes myogenesis by activating the myogenin regulatory network
Q87768403The Smyd Family of Methyltransferases: Role in Cardiac and Skeletal Muscle Physiology and Pathology
Q99627420The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice
Q26853164The functional diversity of protein lysine methylation
Q50956280The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling.
Q58777010The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish
Q39094604Titin and Nebulin in Thick and Thin Filament Length Regulation
Q26765973Titin, a Central Mediator for Hypertrophic Signaling, Exercise-Induced Mechanosignaling and Skeletal Muscle Remodeling
Q41710937Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function
Q36465517Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy
Q38019209Zebrafish models in cardiac development and congenital heart birth defects

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