Inhibition of human cytomegalovirus replication by artemisinins: effects mediated through cell cycle modulation

scientific article published on 13 April 2015

Inhibition of human cytomegalovirus replication by artemisinins: effects mediated through cell cycle modulation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.00262-15
P932PMC publication ID4468661
P698PubMed publication ID25870074

P50authorArun KapoorQ56807955
P2093author name stringRavit Arav-Boger
Ran He
Gary H Posner
Michael Forman
Sujayita Roy
Jennifer R Mazzone
P2860cites workDirect binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4Q28266936
An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activitiesQ28476748
Antiviral Drug Resistance of Human CytomegalovirusQ30430427
Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycleQ31805177
An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremiaQ33678775
Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomersQ33815957
Mutations in the human cytomegalovirus UL27 gene that confer resistance to maribavirQ34437391
A quantitative basis for antiretroviral therapy for HIV-1 infectionQ35812907
Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrestQ35849687
Artemisinin-derived dimer diphenyl phosphate is an irreversible inhibitor of human cytomegalovirus replication.Q36086432
Willmar Schwabe Award 2006: antiplasmodial and antitumor activity of artemisinin--from bench to bedsideQ36758444
In vitro combination of anti-cytomegalovirus compounds acting through different targets: role of the slope parameter and insights into mechanisms of Action.Q37544751
Anticancer activities of artemisinin and its bioactive derivativesQ37626137
In vitro action of antiparasitic drugs, especially artesunate, against Toxoplasma gondiiQ39027347
Cell cycle dysregulation by human cytomegalovirus: influence of the cell cycle phase at the time of infection and effects on cyclin transcription.Q39578269
Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S.Q39877362
Human cytomegalovirus infection inhibits G1/S transition.Q39878302
Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirusQ40229616
Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particlesQ40274359
mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether.Q40712192
Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1.Q41163429
Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell linesQ41273184
Inhibition of the cyclin-dependent kinases at the beginning of human cytomegalovirus infection specifically alters the levels and localization of the RNA polymerase II carboxyl-terminal domain kinases cdk9 and cdk7 at the viral transcriptosomeQ41770253
Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety.Q41830479
Stability and antiviral activity against human cytomegalovirus of artemisinin derivatives.Q42272265
Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitorsQ42616123
Efficacy of artemisinin in experimental visceral leishmaniasisQ43093287
Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses.Q43971464
Monitoring cytomegalovirus infection by antigenemia assay and two distinct plasma real-time PCR methods after hematopoietic stem cell transplantationQ44214552
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacyQ44348694
Molecular modes of action of artesunate in tumor cell lines.Q44517624
Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantationQ46639393
The anti-malaria drug artesunate inhibits replication of cytomegalovirus in vitro and in vivo.Q46834246
Artesunate is ineffective in controlling valganciclovir-resistant cytomegalovirus infectionQ83355653
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectCytomegalovirusQ6946
artemisininQ426921
P304page(s)3870-3879
P577publication date2015-04-13
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleInhibition of human cytomegalovirus replication by artemisinins: effects mediated through cell cycle modulation
P478volume59

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cites work (P2860)
Q39014776Artemisinin and its derivatives in treating protozoan infections beyond malaria
Q92809182Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function
Q37397177Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction
Q58100736Inhibition of Cytomegalovirus Replication with Extended Half-Life Synthetic Ozonides
Q39044770Letermovir for the management of cytomegalovirus infection
Q89683934Orchestrated efforts on host network hijacking: Processes governing virus replication
Q47664127Peroxides with Anthelmintic, Antiprotozoal, Fungicidal and Antiviral Bioactivity: Properties, Synthesis and Reactions.
Q26740588Progress in Treatment of Viral Infections in Children with Acute Lymphoblastic Leukemia
Q56374730The Artemisinin Derivative Artemisone Is a Potent Inhibitor of Human Cytomegalovirus Replication
Q38797660Treatment of CMV infection after allogeneic hematopoietic stem cell transplantation.

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