Arginine-Vasopressin Receptor Blocker Conivaptan Reduces Brain Edema and Blood-Brain Barrier Disruption after Experimental Stroke in Mice

scientific article published on 14 August 2015

Arginine-Vasopressin Receptor Blocker Conivaptan Reduces Brain Edema and Blood-Brain Barrier Disruption after Experimental Stroke in Mice is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1036121Z
P356DOI10.1371/JOURNAL.PONE.0136121
P932PMC publication ID4537303
P698PubMed publication ID26275173
P5875ResearchGate publication ID281119540

P50authorS M JonesQ69374397
P2093author name stringJeong-Woo Seo
Lawrence D Snell
J Paul Elliott
Emil Zeynalov
P2860cites workPhysiologic concentrations of arginine vasopressin activate human platelets in vitroQ71045277
Effects of SR 49059, a new orally active and specific vasopressin V1 receptor antagonist, on vasopressin-induced vasoconstriction in humansQ73879461
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Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolalityQ28508192
Heart disease and stroke statistics--2014 update: a report from the American Heart AssociationQ29547691
Effect of osmotherapy with hypertonic saline on regional cerebral edema following experimental stroke: a study utilizing magnetic resonance imagingQ31119950
Evaluation of the secretory pattern of plasma arginine vasopressin in stroke patients.Q32063277
Water entry into astrocytes during brain edema formationQ33324470
Arginine-vasopressin V1 but not V2 receptor antagonism modulates infarct volume, brain water content, and aquaporin-4 expression following experimental strokeQ33508851
A spoonful of sugar helps the medicine go down: a novel technique to improve oral gavage in miceQ33880128
The basic and clinical pharmacology of nonpeptide vasopressin receptor antagonistsQ34192690
Treatment of stroke related refractory brain edema using mixed vasopressin antagonism: a case report and review of the literatureQ34544328
Selective vasopressin-1a receptor antagonist prevents brain edema, reduces astrocytic cell swelling and GFAP, V1aR and AQP4 expression after focal traumatic brain injuryQ34554602
Arginine-vasopressin V1a receptor inhibition improves neurologic outcomes following an intracerebral hemorrhagic brain injuryQ34713880
The syndrome of inappropriate antidiuretic hormone secretionQ35161602
Neurological impact of vasopressin dysregulation and hyponatremiaQ36377918
Post-treatment with SR49059 improves outcomes following an intracerebral hemorrhagic stroke in miceQ36585575
Vaptans and hyponatremia in critical patientsQ37058365
Mechanisms, risks, and new treatment options for hyponatremiaQ37147030
The perivascular pool of aquaporin-4 mediates the effect of osmotherapy in postischemic cerebral edemaQ37371489
Hyponatremia and antidiuresis syndromeQ37961312
Brain edema formation correlates with perfusion deficit during the first six hours after experimental subarachnoid hemorrhage in rats.Q42146490
Open-label randomized trial of the safety and efficacy of a single dose conivaptan to raise serum sodium in patients with traumatic brain injuryQ42694389
Vasopressin receptor antagonists: the vaptansQ42786149
Effect of small molecule vasopressin V1a and V2 receptor antagonists on brain edema formation and secondary brain damage following traumatic brain injury in mice.Q43139485
Intravenous conivaptan for the treatment of hyponatraemia caused by the syndrome of inappropriate secretion of antidiuretic hormone in hospitalized patients: a single-centre experience.Q43197396
Arginine vasopressin stimulation of cerebral microvascular endothelial cell Na-K-Cl cotransporter activity is V1 receptor and [Ca] dependentQ44173254
Protective effect of the V1a receptor antagonist SR49059 on brain edema formation following middle cerebral artery occlusion in the rat.Q44919821
Modulation of AQP4 expression by the selective V1a receptor antagonist, SR49059, decreases trauma-induced brain edema.Q44947019
The role of vasopressin V1A receptors in cytotoxic brain edema formation following brain injuryQ44980976
Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia.Q45296344
Efficacy and safety of the vasopressin V1A/V2-receptor antagonist conivaptan in acute decompensated heart failure: a dose-ranging pilot studyQ46313153
Etiology, diagnostics and therapy of hyponatremiasQ46490513
V1 receptor activation induced by hemorrhage and sympathoinhibition in the mesentery and hindquarters of spontaneously hypertensive rats.Q46883356
A bolus of conivaptan lowers intracranial pressure in a patient with hyponatremia after traumatic brain injuryQ48213651
Treatment of brain edema with a nonpeptide arginine vasopressin V1 receptor antagonist OPC-21268 in ratsQ48302755
Vasopressin V(1a) receptors mediate posthemorrhagic systemic hypertension thereby determining rebleeding rate and outcome after experimental subarachnoid hemorrhageQ48841321
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectblood–brain barrierQ221694
AVPQ12009087
P304page(s)e0136121
P577publication date2015-08-14
P1433published inPLOS OneQ564954
P1476titleArginine-Vasopressin Receptor Blocker Conivaptan Reduces Brain Edema and Blood-Brain Barrier Disruption after Experimental Stroke in Mice
P478volume10

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cites work (P2860)
Q26741093Arginine Vasopressin and Copeptin in Perinatology
Q55399277Astroglial Modulation of Hydromineral Balance and Cerebral Edema.
Q92711840Blockade of Arginine Vasopressin receptors prevents blood-brain barrier breakdown in Experimental Autoimmune Encephalomyelitis
Q39446196Cardiorenal Syndrome: Role of Arginine Vasopressin and Vaptans in Heart Failure
Q49049427Conivaptan, a Selective Arginine Vasopressin V1a and V2 Receptor Antagonist Attenuates Global Cerebral Edema Following Experimental Cardiac Arrest via Perivascular Pool of Aquaporin-4.
Q38816548Continuous IV Infusion is the Choice Treatment Route for Arginine-vasopressin Receptor Blocker Conivaptan in Mice to Study Stroke-evoked Brain Edema.
Q92500707Emerging Pharmacological Treatments for Cerebral Edema: Evidence from Clinical Studies
Q39044188Mechanisms of Global Cerebral Edema Formation in Aneurysmal Subarachnoid Hemorrhage
Q38874039Recent advances and future directions in preclinical research of arginine-vasopressin (AVP) receptor blocker conivaptan in the context of stroke
Q51612114Telmisartan reduced cerebral edema by inhibiting NLRP3 inflammasome in mice with cold brain injury.
Q38602148Therapeutic time window for conivaptan treatment against stroke-evoked brain edema and blood-brain barrier disruption in mice
Q48752367Treatment with Isorhamnetin Protects the Brain Against Ischemic Injury in Mice
Q40539016Vasopressin Impairment During Sepsis Is Associated with Hypothalamic Intrinsic Apoptotic Pathway and Microglial Activation

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