The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms

scientific article published on August 2001

The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0002-9440(10)61720-8
P932PMC publication ID1850536
P698PubMed publication ID11485907
P5875ResearchGate publication ID11857086

P50authorDavid H. GutmannQ56670301
P2093author name stringH Onda
J Yang
H B Zhang
M B Amin
X Bai
C Cohen
D Frank
P Au
H Northrup
J L Arbiser
D E Fisher
A Loehr
S Mahajan
I Davis
S W Weiss
E Uhlmann
G S Herron
Z K Arbiser
R Yeung
P2860cites workPosttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinaseQ42825331
An L1 element intronic insertion in the black-eyed white (Mitf[mi-bw]) gene: the loss of a single Mitf isoform responsible for the pigmentary defect and inner ear deafnessQ47948567
Carcinomalike monotypic epithelioid angiomyolipoma in patients without evidence of tuberous sclerosis: a clinicopathologic and genetic studyQ47964529
Expression of TERT in early premalignant lesions and a subset of cells in normal tissuesQ47991825
The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomasQ48197957
Renal angiomyolipomas, cysts, and cancer in tuberous sclerosis complexQ48316314
Malignant tumors of the kidney, brain, and soft tissues in children and young adults with the tuberous sclerosis complexQ48343026
Management of Renal Angiomyolipoma:Analysis of 15 CasesQ50865953
Telomerase activity in malignant and benign renal tumorsQ52980097
The use of telomerized cells for tissue engineeringQ53414699
Melanocyte-marker-HMB-45 is regularly expressed in angiomyolipoma of the kidneyQ57290493
Angiomyolipoma of the kidney. Immunoreactivity with HMB-45. Light- and electron-microscopic findingsQ72802734
Clear cell ("sugar") tumor of the lung is a lesion strictly related to angiomyolipoma--the concept of a family of lesions characterized by the presence of the perivascular epithelioid cells (PEC)Q72884493
Hepatic angiomyolipoma in a 26-year-old Caucasian woman with a history of tibial osteosarcomaQ73291156
Immunohistochemical study of microphthalmia transcription factor and tyrosinase in angiomyolipoma of the kidney, renal cell carcinoma, and renal and retroperitoneal sarcomas: comparative evaluation with traditional diagnostic markersQ73364613
Comparison of melanoma antigen recognized by T cells (MART-1) to HMB-45: additional evidence to support a common lineage for angiomyolipoma, lymphangiomyomatosis, and clear cell sugar tumorQ77162074
Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesiclesQ22007978
Interaction between hamartin and tuberin, the TSC1 and TSC2 gene productsQ24314470
Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatusQ24323303
Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) geneQ24561849
Creation of human tumour cells with defined genetic elementsQ28141602
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34Q28245141
Identification and characterization of the tuberous sclerosis gene on chromosome 16Q28257738
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformationQ28286516
Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcomaQ28343226
Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic backgroundQ28507548
Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in miceQ28591496
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristicsQ33962085
Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.Q33970751
Germ-Line Mutational Analysis of the TSC2 Gene in 90 Tuberous-Sclerosis PatientsQ34384437
Causes of Death in Patients With Tuberous SclerosisQ34794286
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.Q35076272
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.Q35186010
Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumorsQ35764929
Isolation of mouse stromal cells associated with a human tumor using differential diphtheria toxin sensitivityQ35787834
Mild osteopetrosis in the microphthalmia-oak ridge mouse. A model for intermediate autosomal recessive osteopetrosis in humans.Q35796483
Genetic and epigenetic changes in human epithelial cells immortalized by telomeraseQ35810077
Interleukin-1 beta-modulated gene expression in immortalized human chondrocytesQ35824517
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathwaysQ35964906
Age-resolving Osteopetrosis: A Rat Model Implicating Microphthalmia and the Related Transcription Factor TFE3Q36400364
An essential role of phosphatidylinositol 3-kinase in myogenic differentiation.Q36730708
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalizationQ36754020
Immortalization of human fibroblasts transformed by origin-defective simian virus 40Q36919581
Chromosomal analysis of renal angiomyolipoma by comparative genomic hybridization: evidence for clonal originQ38469156
The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromesQ40902746
Implications of isoform multiplicity of microphthalmia-associated transcription factor in the pathogenesis of auditory-pigmentary syndromes.Q40921076
Absence of cancer-associated changes in human fibroblasts immortalized with telomeraseQ40978424
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomeraseQ41053498
Human endothelial cell life extension by telomerase expressionQ41688544
Angiomyolipoma of kidney.Q41721302
Episomal vectors rapidly and stably produce high-titer recombinant retrovirusQ42810400
P4510describes a project that usesSV6Q54970977
SV7Q54970981
SV7tertQ54970982
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell lineQ21014462
P304page(s)483-491
P577publication date2001-08-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleThe generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms
P478volume159

Reverse relations

described by source (P1343)
Q54970977SV6
Q54970981SV7
Q54970982SV7tert

cites work (P2860)
Q33380187Anti-EGFR antibody efficiently and specifically inhibits human TSC2-/- smooth muscle cell proliferation. Possible treatment options for TSC and LAM.
Q44552007Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways
Q53322616Exosomes mediate the acquisition of the disease phenotypes by cells with normal genome in tuberous sclerosis complex
Q79195309Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex
Q83731033Expression of MiTF May be Helpful in Differentiating Cellular Neurothekeoma From Plexiform Fibrohistiocytic Tumor (Histiocytoid Predominant) in a Partial Biopsy Specimen
Q24672066Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: are angiomyolipomas neoplasms of stem cells?
Q35789048Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis
Q47662133Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis.
Q37173102Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis
Q35133544Involvement of NADPH oxidases in suppression of cyclooxygenase-2 promoter-dependent transcriptional activities by sesamol.
Q35085208Isolation and growth of smooth muscle-like cells derived from tuberous sclerosis complex-2 human renal angiomyolipoma: epidermal growth factor is the required growth factor
Q33904951Lymphangioleiomyomatosis and TSC2-/- cells
Q40461254Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB.
Q75192426Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma
Q35684534NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Q24561606NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin
Q47303044Notch transactivates Rheb to maintain the multipotency of TSC-null cells
Q37734001PPARG is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic target
Q46732170Pathological alterations involve the entire skin physiological milieu in infantile and early-childhood port-wine stain.
Q34850028Pediatric liver tumors and hepatic ontogenesis: common and distinctive pathways
Q37051667Possible mechanisms of disease development in tuberous sclerosis
Q27301399Real-Time Monitoring of Tumorigenesis, Dissemination, & Drug Response in a Preclinical Model of Lymphangioleiomyomatosis/Tuberous Sclerosis Complex
Q33991599TSC2 epigenetic defect in primary LAM cells. Evidence of an anchorage-independent survival
Q37197352The methylation of the TSC2 promoter underlies the abnormal growth of TSC2 angiomyolipoma-derived smooth muscle cells
Q35103344Tumor necrosis factor-related apoptosis-inducing ligand can induce apoptosis in subsets of premalignant cells
Q51896311Use of hyperspectral imaging to distinguish normal, precancerous, and cancerous cells.
Q48534683mTORC1 Inhibition Is an Effective Treatment for Sporadic Renal Angiomyolipoma
Q33919744mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress

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