Ras signaling contributes to survival of human T-cell leukemia/lymphoma virus type 1 (HTLV-1) Tax-positive T-cells

scientific article published on March 2012

Ras signaling contributes to survival of human T-cell leukemia/lymphoma virus type 1 (HTLV-1) Tax-positive T-cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S10495-011-0676-Z
P932PMC publication ID3279637
P698PubMed publication ID22127644
P5875ResearchGate publication ID51840412

P50authorEnrica RumiatoQ55755027
P2093author name stringDaniela Saggioro
Enrica Rumiato
Giovanna Stoppa
P2860cites workThe Hallmarks of CancerQ221226
The HTLV-1 Tax interactomeQ21093224
Oncogenic Kras initiates leukemia in hematopoietic stem cellsQ27331698
Protein profile of tax-associated complexesQ28207756
ras oncogenes in human cancer: a reviewQ29547769
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphomaQ29615115
Hyperactive Ras in developmental disorders and cancerQ29616397
Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancerQ33554443
Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vectorQ33854474
Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13II sensitizes Jurkat T cells to Ras-mediated apoptosisQ33908852
RAS inhibitors: potential for cancer therapeuticsQ34046314
Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugsQ34060806
Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cellsQ34255923
Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human seraQ34276501
Molecular mechanisms of cellular transformation by HTLV-1 Tax.Q34450092
Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancerQ34540268
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancerQ34765346
GTPases and T cell activationQ35096692
Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear specklesQ35164261
The cytoskeleton of digitonin-treated rat hepatocytesQ36393736
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approachesQ37079191
Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformationQ37086934
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.Q37109225
Deregulation of signaling pathways in acute myeloid leukemiaQ37240553
Cis-acting sequences responsible for the transcriptional activation of human T-cell leukemia virus type I constitute a conditional enhancerQ37397708
Control of cell death pathways by HTLV-1 proteinsQ37410437
Phosphoinositide signalling in cancer: beyond PI3K and PTEN.Q37736257
Development of phosphoinositide-3 kinase pathway inhibitors for advanced cancerQ37738756
HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell deathQ37766003
Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinaseQ38298684
Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesisQ39021217
Enhanced MDR1 gene expression in human T-cell leukemia virus-I-infected patients offers new prospects for therapy.Q39162048
Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular cloneQ39594099
Role for protein geranylgeranylation in adult T-cell leukemia cell survivalQ39919928
Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, JurkatQ40116365
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoproteinQ40325197
Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cellsQ40399507
Relevance of CREB phosphorylation in the anti-apoptotic function of human T-lymphotropic virus type 1 tax protein in serum-deprived murine fibroblastsQ40527113
Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation.Q40718584
Block of a mitochondrial-mediated apoptotic pathway in Tax-expressing murine fibroblasts.Q40778754
Tax of the human T-lymphotropic virus type I transactivates promoter of the MDR-1 geneQ41090653
Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypesQ41715443
Ras activation in normal white blood cells and childhood acute lymphoblastic leukemia.Q41736550
Farnesyl transferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cellsQ42803458
HTLV-1 Tax protein cooperates with Ras in protecting cells from apoptosis.Q43762842
Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I.Q44367844
Antiapoptotic effect of human T-cell leukemia virus type 1 tax protein correlates with its creb transcriptional activity.Q45419690
A combined treatment of HeLa cells with the farnesyl protein transferase inhibitor L-744,832 and cisplatin significantly increases the therapeutic effect as compared to cisplatin monotherapyQ46893652
Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude miceQ46971529
Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.Q53596562
Tax-induced HTLV-I LTR transcriptional activation is modulated by phosphorylation.Q55240909
Comparative analysis of the HTLV-I Rex and HIV-1 Rev trans-regulatory proteins and their RNA response elements.Q55242179
T-cell lymphoma cell lines (HUT102 and HUT78) established at the National Cancer Institute: history and importance to understanding the biology, clinical features, and therapy of cutaneous T-cell lymphomas (CTCL) and adult T-cell leukemia-lymphomasQ71529097
P433issue3
P921main subjectHuman T-lymphotropic virus 1Q1280388
P304page(s)219-228
P577publication date2012-03-01
P1433published inApoptosisQ15749546
P1476titleRas signaling contributes to survival of human T-cell leukemia/lymphoma virus type 1 (HTLV-1) Tax-positive T-cells
P478volume17

Reverse relations

cites work (P2860)
Q27027114Biosensors in clinical practice: focus on oncohematology
Q38961040Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax.
Q37644070Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis
Q91644762Role of rat sarcoma virus mutations in cancer and potential target for cancer therapy
Q26995410The modulation of apoptosis by oncogenic viruses

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