Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription

scientific article published on July 2014

Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/FEBS.12866
P8608Fatcat IDrelease_v2uxyslijrbcxbscr5vda5g2je
P932PMC publication ID4474172
P698PubMed publication ID24910119
P5875ResearchGate publication ID262941247

P2093author name stringDhirendra P Singh
Bhavana Chhunchha
Eri Kubo
Nigar Fatma
P2860cites workAn extended consensus motif enhances the specificity of substrate modification by SUMOQ24306729
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Sumo paralogs: redundancy and divergenciesQ27865265
SUMO-1 modification activated GATA4-dependent cardiogenic gene activityQ40520891
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Peroxiredoxin distribution in the mouse brain with emphasis on neuronal populations affected in neurodegenerative disordersQ42489979
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The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modificationQ43548130
Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defensesQ44193411
TAT-mediated peroxiredoxin 5 and 6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytesQ45130630
Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity.Q45929966
SUMO-1 conjugation blocks beta-amyloid-induced astrocyte reactivity.Q51013337
SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of β-catenin.Q54286128
A fluorescence-resonance-energy-transfer-based protease activity assay and its use to monitor paralog-specific small ubiquitin-like modifier processingQ60304859
p300 Transcriptional Repression Is Mediated by SUMO ModificationQ60304936
TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacityQ80470954
Impaired homeostasis and phenotypic abnormalities in Prdx6-/-mice lens epithelial cells by reactive oxygen species: increased expression and activation of TGFbetaQ81628795
Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growthQ39283761
SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitorsQ39525345
SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent mannerQ39598389
Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbateQ39626948
SENP1 participates in the dynamic regulation of Elk-1 SUMOylationQ39722920
SUMOylation of tissue transglutaminase as link between oxidative stress and inflammation.Q39821994
Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidationQ39952558
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cellsQ40068850
Transient global cerebral ischemia induces a massive increase in protein sumoylationQ40120643
Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation.Q40128108
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.Q40157263
SUMO-1 modification increases human SOD1 stability and aggregationQ40257453
Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcriptionQ40331129
Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activitiesQ40405262
SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4.Q40435185
Global shifts in protein sumoylation in response to electrophile and oxidative stress.Q40479648
Sumoylation: a regulatory protein modification in health and diseaseQ27865267
SUMOylation regulates the SNF1 protein kinaseQ27932790
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Cell cycle-regulated attachment of the ubiquitin-related protein SUMO to the yeast septinsQ27936336
A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activityQ28115472
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3Q28145507
A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3Q28201630
Peroxiredoxin, a novel family of peroxidasesQ28215752
SUMO: a history of modificationQ28243325
Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolismQ28250381
SUMO-modified PCNA recruits Srs2 to prevent recombination during S phaseQ28254244
A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitusQ28259884
Mutual interactions between the SUMO and ubiquitin systems: a plea of no contestQ28269305
Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6Q28274071
SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?Q28280175
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activationQ28282094
Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic processQ28284760
SUMO-1 controls the protein stability and the biological function of phosducinQ28292447
Modification in reverse: the SUMO proteasesQ28302162
TRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylationQ28509337
SUMOylation regulates kainate-receptor-mediated synaptic transmissionQ28576922
Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stressQ28587822
SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localizationQ28612080
Protein modification by SUMOQ29547919
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targetingQ29619527
Lens epithelium-derived growth factor: increased resistance to thermal and oxidative stresses.Q30708799
Phospholipid hydroperoxides are substrates for non-selenium glutathione peroxidaseQ30736573
Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposureQ30877449
SUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoterQ33872393
Ubiquitin-like proteins: new wines in new bottlesQ33901542
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesisQ33902403
Crosstalk between JNK and SUMO signaling pathways: deSUMOylation is protective against H2O2-induced cell injuryQ34099050
PDSM, a motif for phosphorylation-dependent SUMO modificationQ34248164
Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoterQ34277622
Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and AngiogenesisQ34299153
SUMO: of branched proteins and nuclear bodiesQ34435551
Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.Q34491014
SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4.Q34505683
Ubiquitin-related modifier SUMO1 and nucleocytoplasmic transport.Q34637173
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Regulating the regulators: lysine modifications make their markQ35044538
Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosisQ35321980
Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stressQ35572110
Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosisQ35621378
SUMO modification of proteins other than transcription factorsQ35812431
Oxidative stress and aberrant signaling in aging and cognitive declineQ35987295
Peroxiredoxin 6 delivery attenuates TNF-alpha-and glutamate-induced retinal ganglion cell death by limiting ROS levels and maintaining Ca2+ homeostasisQ36370793
PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cellsQ36393923
Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulationQ36763853
SUMO is growing senescentQ36765403
SUMO junction-what's your function? New insights through SUMO-interacting motifsQ36839119
Insulin resistance is an evolutionarily conserved physiological mechanism at the cellular level for protection against increased oxidative stressQ36875724
Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunctionQ36995104
Rpb1 sumoylation in response to UV radiation or transcriptional impairment in yeastQ37156247
SUMO under stress.Q37269500
SUMOylation and De-SUMOylation: wrestling with life's processesQ37325310
Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblastsQ37349403
Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxinQ37358101
Loss of NF-kappaB control and repression of Prdx6 gene transcription by reactive oxygen species-driven SMAD3-mediated transforming growth factor beta signalingQ37371652
Sumoylation and human disease pathogenesisQ37413787
The role of ubiquitin in NF-kappaB regulatory pathways.Q37505087
SUMO and ubiquitin paths converge.Q37674654
Inflammation and oxidative stress in carcinogenesisQ37711943
Peroxiredoxin 6: A Bifunctional Enzyme with Glutathione Peroxidase and Phospholipase A2ActivitiesQ37797498
SUMO and its role in human diseasesQ37863913
Post-translational modification of human heat shock factors and their functions: a recent update by proteomic approachQ38001752
Sumoylation in neurodegenerative diseasesQ38046126
Starting and stopping SUMOylation. What regulates the regulator?Q38118140
Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of agingQ38121750
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectreactive oxygen speciesQ424361
protein sumoylationQ3503705
P304page(s)3357-3381
P577publication date2014-07-01
P1433published inFEBS JournalQ1388041
P1476titleAberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription
P478volume281

Reverse relations

cites work (P2860)
Q58581454Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities
Q35837625Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains
Q64096671Peroxiredoxin6 in Endothelial Signaling
Q46261257SUMO1/UBC9‑decreased Nox1 activity inhibits reactive oxygen species generation and apoptosis in diabetic retinopathy
Q91690821SUMOylation Evoked by Oxidative Stress Reduced Lens Epithelial Cell Antioxidant Functions by Increasing the Stability and Transcription of TP53INP1 in Age-Related Cataracts
Q58771413SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis
Q42621403Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress
Q90383870Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells
Q37744859Sumoylation-deficient Prdx6 gains protective function by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation
Q58744776Sumoylation-deficient Prdx6 repairs aberrant Sumoylation-mediated Sp1 dysregulation-dependent Prdx6 repression and cell injury in aging and oxidative stress
Q60948441The Role of Peroxiredoxin 6 in Cell Signaling
Q41040989The phospholipase A2 activity of peroxiredoxin 6 promotes cancer cell death induced by tumor necrosis factor alpha in hepatocellular carcinoma

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