Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters.

scholarly article

Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2006PNAS..10317349K
P356DOI10.1073/PNAS.0603079103
P932PMC publication ID1859933
P698PubMed publication ID17088550
P5875ResearchGate publication ID6707814

P50authorDalibor BlazekQ63980675
P2093author name stringB Matija Peterlin
Jiri Kohoutek
P2860cites workEnhancement of CIITA transcriptional function by ubiquitinQ22330796
Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cellsQ24294541
Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcriptionQ24294985
Cyclin T1 but not cyclin T2a is induced by a post-transcriptional mechanism in PAMP-activated monocyte-derived macrophagesQ81579403
HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SKQ24294998
Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNAQ24298519
HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor bQ24304885
Class II transactivator: mastering the art of major histocompatibility complex expressionQ24552298
MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent mannerQ24679741
Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFbQ25255186
7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexesQ28116607
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infectionQ28144181
The bare lymphocyte syndrome and the regulation of MHC expressionQ28204378
The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcriptionQ28206012
Genetic control of MHC class II expressionQ28216149
Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 TatQ28247078
The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1Q28254964
Ablation of the CLP-1 gene leads to down-regulation of the HAND1 gene and abnormality of the left ventricle of the heart and fetal deathQ28513084
Elongation by RNA polymerase II: the short and long of itQ29614529
Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA.Q33886675
Two distinct gamma interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor betaQ33957154
Interferon-gamma-induced chromatin remodeling at the CIITA locus is BRG1 dependentQ34086467
Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene.Q36369564
Expression of MHC II genesQ36397192
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.Q37550149
BLIMP-I mediates extinction of major histocompatibility class II transactivator expression in plasma cellsQ38303081
Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genesQ39676027
CIITA regulates transcription onset viaSer5-phosphorylation of RNA Pol IIQ39927810
Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failureQ39996386
Increased HEXIM1 expression during erythroleukemia and neuroblastoma cell differentiationQ40362490
Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors.Q40449331
Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.Q40699269
Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencingQ40700621
Dendritic cell-specific MHC class II transactivator contains a caspase recruitment domain that confers potent transactivation activityQ40816207
Binding and cooperative interactions between two B cell-specific transcriptional coactivators.Q41195461
Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFbQ43192544
Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytesQ46792411
Differentiation of Burkitt lymphoma cells by hexamethylenbisacetamideQ70267312
Generation of deletion and point mutations with one primer in a single cloning stepQ73206310
Constitutive expression of MHC class II genes in melanoma cell lines results from the transcription of class II transactivator abnormally initiated from its B cell-specific promoterQ74064940
Varying functions of specific major histocompatibility class II transactivator promoter III and IV elements in melanoma cell linesQ74120243
P433issue46
P407language of work or nameEnglishQ1860
P304page(s)17349-17354
P577publication date2006-11-06
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleHexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters
P478volume103

Reverse relations

cites work (P2860)
Q41849042AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells
Q35762663APOBEC3 proteins inhibit LINE-1 retrotransposition in the absence of ORF1p binding
Q37972643Control of HIV latency by epigenetic and non-epigenetic mechanisms
Q37233387Cyclin T2 is essential for mouse embryogenesis.
Q37356131P-TEFb- the final frontier
Q40210146Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages
Q42129475Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1
Q27728130hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA

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