Partial Support Ventilation and Mitochondrial-Targeted Antioxidants Protect against Ventilator-Induced Decreases in Diaphragm Muscle Protein Synthesis.

scientific article published on 11 September 2015

Partial Support Ventilation and Mitochondrial-Targeted Antioxidants Protect against Ventilator-Induced Decreases in Diaphragm Muscle Protein Synthesis. is …
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P819ADS bibcode2015PLoSO..1037693H
P356DOI10.1371/JOURNAL.PONE.0137693
P932PMC publication ID4567376
P698PubMed publication ID26361212
P5875ResearchGate publication ID281679385

P50authorW Bradley NelsonQ79762942
P2093author name stringHazel H Szeto
James D Fluckey
Michael P Wiggs
Ashley J Smuder
Scott K Powers
Matthew B Hudson
Kevin L Shimkus
P2860cites workPRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinaseQ24300915
Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factorsQ28205299
Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signallingQ28572937
Negative pressure ventilation and positive pressure ventilation promote comparable levels of ventilator-induced diaphragmatic dysfunction in rats.Q50848560
Detrimental effects of short-term mechanical ventilation on diaphragm function and IGF-I mRNA in rats.Q51299869
Low load inspiratory muscle training increases diaphragmatic fiber dimensions in rats.Q54143753
The determination of low d5-phenylalanine enrichment (0.002-0.09 atom percent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gass chromatography/electron ionization mass spectrometryQ56227948
Two-sidearm tracheal cannula for respiratory airflow measurements in small animalsQ71828942
Measurement of very low stable isotope enrichments by gas chromatography/mass spectrometry: application to measurement of muscle protein synthesisQ73589672
Weaning from mechanical ventilationQ79971379
Weaning from mechanical ventilationQ80242082
Leupeptin inhibits ventilator-induced diaphragm dysfunction in ratsQ28575964
Inhibition of protein synthesis in cortical neurons during exposure to hydrogen peroxideQ31961962
Oxidative stress is required for mechanical ventilation-induced protease activation in the diaphragm.Q33841166
Inhibition of the ubiquitin-proteasome pathway does not protect against ventilator-induced accelerated proteolysis or atrophy in the diaphragmQ33897472
Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant productionQ34003272
Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilationQ34016668
miR-182 attenuates atrophy-related gene expression by targeting FoxO3 in skeletal muscleQ34062884
Oxidation enhances myofibrillar protein degradation via calpain and caspase-3.Q34091517
Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation.Q34424860
Mechanical ventilation-induced oxidative stress in the diaphragm: role of heme oxygenase-1Q34764555
Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans.Q34764722
Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injuryQ35012392
Disorders of the respiratory musclesQ35162640
Ventilator-induced diaphragmatic dysfunctionQ35636184
Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patientsQ35672602
Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophyQ35840869
Cross-talk between the calpain and caspase-3 proteolytic systems in the diaphragm during prolonged mechanical ventilationQ35980921
Endurance exercise attenuates ventilator-induced diaphragm dysfunction.Q36104504
mTOR signaling and the molecular adaptation to resistance exercise.Q36649624
Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm.Q36993117
Xanthine oxidase contributes to mechanical ventilation-induced diaphragmatic oxidative stress and contractile dysfunction.Q37174937
Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weaknessQ37197868
Nuclear factor-κB signaling contributes to mechanical ventilation-induced diaphragm weakness*Q37205760
Diaphragm weakness in mechanically ventilated critically ill patientsQ37343222
miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated exportQ37629026
Exercise-induced oxidative stress in humans: cause and consequences.Q37822086
Ventilator-induced diaphragm dysfunction: cause and effectQ38120655
Mitochondria-targeted peptide prevents mitochondrial depolarization and apoptosis induced by tert-butyl hydroperoxide in neuronal cell linesQ40363556
Respiratory muscles and ventilatory failure.Q41358847
Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytesQ42489522
N-Acetylcysteine protects the rat diaphragm from the decreased contractility associated with controlled mechanical ventilationQ42757101
Tension-time index, fatigue, and energetics in isolated rat diaphragm: a new experimental modelQ44583916
Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injuryQ44922430
Trolox attenuates mechanical ventilation-induced diaphragmatic dysfunction and proteolysisQ45063932
Mechanical ventilation depresses protein synthesis in the rat diaphragmQ47945811
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectventilatorQ813243
P304page(s)e0137693
P577publication date2015-09-11
P1433published inPLOS OneQ564954
P1476titlePartial Support Ventilation and Mitochondrial-Targeted Antioxidants Protect against Ventilator-Induced Decreases in Diaphragm Muscle Protein Synthesis
P478volume10