Ca(2+), calpain and 3-phosphorylated phosphatidyl inositides; decision-making signals in neutrophils as potential targets for therapeutics

scientific article published on May 2004

Ca(2+), calpain and 3-phosphorylated phosphatidyl inositides; decision-making signals in neutrophils as potential targets for therapeutics is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1211/0022357023466
P698PubMed publication ID15142332

P2093author name stringWei Tian
Iraj Laffafian
Maurice B Hallett
Sharon Dewitt
P2860cites workHigh micromolar Ca2+ beneath the plasma membrane in stimulated neutrophilsQ77090454
Extracellular Ca2+ regulates the respiratory burst of human neutrophilsQ77305226
Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transductionQ22253158
Crystal structure of calcium bound domain VI of calpain at 1.9 A resolution and its role in enzyme assembly, regulation, and inhibitor bindingQ27740706
The calpain systemQ28185062
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivoQ28203353
Role and regulation of TRP channels in neutrophil granulocytesQ28206283
Essential role of phosphoinositide 3-kinase delta in neutrophil directional movementQ28210580
Calpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the ratQ28360091
Talin Binding to Integrin ß Tails: A Final Common Step in Integrin ActivationQ29617809
The PX domains of p47phox and p40phox bind to lipid products of PI(3)KQ30016925
Calpain regulates neutrophil chemotaxisQ30477730
Polarization of chemoattractant receptor signaling during neutrophil chemotaxisQ30493167
Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domainQ30671443
Cytosolic free Ca(2+) changes and calpain activation are required for beta integrin-accelerated phagocytosis by human neutrophilsQ31114092
WASP and N-WASP in human platelets differ in sensitivity to protease calpainQ33339682
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarityQ33660588
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.Q33889530
Leukocytes navigate by compass: roles of PI3Kgamma and its lipid productsQ34069723
Cutting to the chase: calpain proteases in cell motilityQ34537620
Roles of PI3Ks in leukocyte chemotaxis and phagocytosisQ34560905
Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreadingQ38290020
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.Q39584074
Calcium signalling is altered in myeloid cells with a deficiency in NADPH oxidase activityQ40661905
Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD.Q40673306
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migrationQ40900789
Exclusion of exogenous phosphatidylinositol-3,4,5-trisphosphate from neutrophil-polarizing pseudopodia: stabilization of the uropod and cell polarity.Q41011213
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influxQ41533197
SK&F 96365, a novel inhibitor of receptor-mediated calcium entryQ41771065
Tyrosine phosphorylation-dependent activation of phosphatidylinositide 3-kinase occurs upstream of Ca2+-signalling induced by Fcgamma receptor cross-linking in human neutrophilsQ41817803
Control of plasma-membrane Ca2+ entry by the intracellular Ca2+ stores. Kinetic evidence for a short-lived mediatorQ41985650
Actin polymerization in neutrophils is triggered without a requirement for a rise in cytoplasmic Ca2+.Q42162570
Characterization of receptor-mediated and store-regulated Ca2+ influx in human neutrophils.Q42832820
Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentrationQ43500706
Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat.Q43623079
Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damageQ43756669
Does neutrophil CD38 have a role in Ca++ signaling triggered by beta2 integrin?Q43943672
Holding back neutrophil aggression; the oxidase has potentialQ44406118
Phagosomal oxidative activity during beta2 integrin (CR3)-mediated phagocytosis by neutrophils is triggered by a non-restricted Ca2+ signal: Ca2+ controls time not spaceQ44456498
Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosisQ44564211
A soluble cellular factor directly stimulates Ca2+ entry in neutrophilsQ72402015
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
decision makingQ1331926
P304page(s)565-571
P577publication date2004-05-01
P1433published inJournal of Pharmacy and PharmacologyQ10532762
P1476titleCa(2+), calpain and 3-phosphorylated phosphatidyl inositides; decision-making signals in neutrophils as potential targets for therapeutics
P478volume56

Reverse relations

cites work (P2860)
Q30496310Activation of store-operated I(CRAC) by hydrogen peroxide.
Q35157505Calpain chronicle--an enzyme family under multidisciplinary characterization
Q41829112Direct effect of human immunodeficiency virus protease inhibitors on neutrophil function and apoptosis via calpain inhibition
Q30497308Necessity of inositol (1,4,5)-trisphosphate receptor 1 and mu-calpain in NO-induced osteoclast motility

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