Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility

scientific article published on May 2002

Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/01.RES.0000016165.23795.1F
P932PMC publication ID1866365
P698PubMed publication ID11988485

P2093author name stringBrenda A Wilson
Abdelkarim Sabri
Susan F Steinberg
P2860cites workProtein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytesQ71903459
Signal transduction in atria and ventricles of mice with transient cardiac expression of activated G protein alpha(q)Q73204520
Stimulation of protein kinase C modulates insulin-like growth factor-1-induced akt activation in PC12 cellsQ73731241
Signaling properties and functions of two distinct cardiomyocyte protease-activated receptorsQ73825680
The alpha(1)-adrenoceptor subtype- and protein kinase C isoform-dependence of Norepinephrine's actions in cardiomyocytesQ73910279
Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophyQ74469678
Protein kinase Czeta is a negative regulator of protein kinase B activityQ74620344
Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytesQ77148695
Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase CQ28208351
Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytesQ28254946
Protein kinase C isoform expression and regulation in the developing rat heartQ28258963
Protein kinase C is regulated in vivo by three functionally distinct phosphorylationsQ28616082
Protein kinase C deltaQ33545096
Gq signaling in cardiac adaptation and maladaptationQ33586200
Multiple pathways control protein kinase C phosphorylationQ33838086
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.Q33944297
Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylationQ34086422
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failureQ36286936
Transgenic Galphaq overexpression induces cardiac contractile failure in miceQ36302328
Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinaseQ37429675
Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cellsQ40841362
Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunitsQ40855288
Pasteurella multocida toxin stimulates mitogen-activated protein kinase via G(q/11)-dependent transactivation of the epidermal growth factor receptor.Q40906001
Protein kinase C-alpha overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawalQ40912226
Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha.Q41172171
Multisite dephosphorylation and desensitization of conventional protein kinase C isotypesQ42030453
The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinaseQ42496982
Pasteurella multocida toxin, a potent intracellularly acting mitogen, induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact assembly in Swiss 3T3 cellsQ42817645
Pleiotropic effects of Pasteurella multocida toxin are mediated by Gq-dependent and -independent mechanisms. involvement of Gq but not G11.Q43509257
Death by protein kinase C inhibitor: a stressful eventQ43768600
Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.Q46652497
Endothelin ETA receptor regulates signaling and ANF gene expression via multiple G protein-linked pathwaysQ46873898
Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma.Q47828172
Pasteurella multocida toxin activates the inositol triphosphate signaling pathway in Xenopus oocytes via G(q)alpha-coupled phospholipase C-beta1.Q48965374
P433issue8
P921main subjectapoptotic processQ14599311
Pasteurella multocidaQ310656
P304page(s)850-857
P577publication date2002-05-01
P1433published inCirculation ResearchQ2599020
P1476titleDual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility
P478volume90

Reverse relations

cites work (P2860)
Q35136326A central role of EGF receptor transactivation in angiotensin II -induced cardiac hypertrophy
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Q43128781Application of intact cell-based NFAT-beta-lactamase reporter assay for Pasteurella multocida toxin-mediated activation of calcium signaling pathway
Q42827288Calcineurin-independent inhibition of 3T3-L1 adipogenesis by Pasteurella multocida toxin: suppression of Notch1, stabilization of beta-catenin and pre-adipocyte factor 1.
Q38046798Cardiac intercellular communication: are myocytes and fibroblasts fair-weather friends?
Q28578902Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3
Q35194433Cellular and molecular action of the mitogenic protein-deamidating toxin from Pasteurella multocida
Q44302141Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations
Q28572126Distinct signaling functions for Shc isoforms in the heart
Q35921462Distinctive activation mechanisms and functions for protein kinase Cdelta
Q34785623Ecology and physiology of infectious bacteria--implications for biotechnology
Q46677874Effect of chronic ethanol ingestion and gender on heart left ventricular p53 gene expression
Q42873628Evidence that apoptotic signalling in hypertrophic cardiomyocytes is determined by mitochondrial pathways involving protein kinase Cδ
Q37550751Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes
Q42317785IP3R and RyR calcium channels are involved in neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α.
Q35763693Intracellular signaling pathways for norepinephrine- and endothelin-1-mediated regulation of myocardial cell apoptosis
Q44328670Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes
Q36562143Mammalian target of rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss 3T3 cells
Q44274539Mechanisms of protease-activated receptor-4 actions in cardiomyocytes. Role of Src tyrosine kinase
Q42833029Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin
Q37671804PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo
Q36850768Pasteurella multocida toxin (PMT) upregulates CTGF which leads to mTORC1 activation in Swiss 3T3 cells
Q38842849Pasteurella multocida toxin activates various heterotrimeric G proteins by deamidation
Q35568308Pasteurella multocida toxin as a tool for studying Gq signal transduction
Q35534871Pasteurella multocida toxin interaction with host cells: entry and cellular effects
Q44557194Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13.
Q37674817Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury
Q35566719Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure
Q44991365Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes
Q39142718Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart
Q38037338Protein kinase cδ in apoptosis: a brief overview
Q37781061Recent insights into Pasteurella multocida toxin and other G-protein-modulating bacterial toxins
Q53885921Role of inositol 1,4,5-trisphosphate receptors in alpha1-adrenergic receptor-induced cardiomyocyte hypertrophy.
Q44394259Stimulation of the alpha1A adrenergic receptor inhibits PDGF-induced PDGF beta receptor Tyr751 phosphorylation and PI 3-kinase activation
Q36575511The C3 domain of Pasteurella multocida toxin is the minimal domain responsible for activation of Gq-dependent calcium and mitogenic signaling
Q34485166The sarcomeric Z-disc: a nodal point in signalling and disease

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