Disparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination.

scientific article published on 25 September 2015

Disparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1039008G
P356DOI10.1371/JOURNAL.PONE.0139008
P932PMC publication ID4583481
P698PubMed publication ID26407166
P5875ResearchGate publication ID282291587

P50authorLeslie A KirbyQ84494521
Justin D GlennQ39186971
Matthew D SmithQ39186985
P2093author name stringKatharine A Whartenby
Emily G Baxi
P2860cites workHuman bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuliQ29618769
CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosisQ30493331
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Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppressionQ33898626
The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system.Q34122755
Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferationQ34168051
Characterization of oligodendroglial populations in mouse demyelinating disease using flow cytometry: clues for MS pathogenesisQ34232425
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapyQ34259085
Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phaseQ34538693
Promotion of remyelination by adipose mesenchymal stem cell transplantation in a cuprizone model of multiple sclerosisQ34828914
Variable behavior and complications of autologous bone marrow mesenchymal stem cells transplanted in experimental autoimmune encephalomyelitis.Q50524244
Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy.Q50767537
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Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation.Q53281677
Regulation of suppressing and activating effects of mesenchymal stem cells on the encephalitogenic potential of MBP68–86-specific lymphocytesQ57247334
Mesenchymal Stem Cell-Mediated Immunosuppression Occurs via Concerted Action of Chemokines and Nitric OxideQ61645540
Cutting edge: in vitro-generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitisQ75424618
Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cellsQ79208808
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Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelinationQ34903919
Oral Administration of Lactococcus lactis Expressing Synthetic Genes of Myelin Antigens in Decreasing Experimental Autoimmune Encephalomyelitis in RatsQ35717195
Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative settingQ35849125
Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis.Q35899107
IL-17-induced Act1-mediated signaling is critical for cuprizone-induced demyelinationQ36142154
Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models.Q36188460
Virtues and pitfalls of EAE for the development of therapies for multiple sclerosisQ36254088
Inflammatory demyelination is not central to the pathogenesis of multiple sclerosisQ36299392
Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitisQ37055766
IL-23 promotes maintenance but not commitment to the Th17 lineageQ37183888
Peptide-based immunotherapy of experimental autoimmune encephalomyelitis without anaphylaxisQ37235161
Growth of a rat neuroblastoma cell line in serum-free supplemented mediumQ37313160
Multiple sclerosis - candidate mechanisms underlying CNS atrophyQ37691873
Mesenchymal Stem Cells: Mechanisms of InflammationQ37809081
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Peptide immunotherapy in experimental autoimmune encephalomyelitisQ38525786
Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitisQ39178437
Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype.Q39698715
Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivoQ39823115
Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivoQ40662801
Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model.Q41790153
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.Q42767100
Human mesenchymal stem cells infiltrate the spinal cord, reduce demyelination, and localize to white matter lesions in experimental autoimmune encephalomyelitis.Q43578851
The in vivo and in vitro induction of anterior chamber associated immune deviation to myelin antigens in C57BL/6 miceQ44999687
In vitro-induced cell-mediated immune deviation to encephalitogenic antigensQ46340968
Oral tolerance reduces Th17 cells as well as the overall inflammation in the central nervous system of EAE miceQ48151907
Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis miceQ48497239
Demyelination of the superior cerebellar peduncle in the mouse induced by cuprizoneQ48633695
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectexperimental autoimmune encephalomyelitisQ494066
mesenchymal stem cellQ1922379
cuprizoneQ27262585
P304page(s)e0139008
P577publication date2015-09-25
P1433published inPLOS OneQ564954
P1476titleDisparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination
P478volume10

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cites work (P2860)
Q28595492Intravenous transplantation of mouse embryonic stem cells attenuates demyelination in an ICR outbred mouse model of demyelinating diseases
Q64230072Potential Therapeutic Features of Human Amniotic Mesenchymal Stem Cells in Multiple Sclerosis: Immunomodulation, Inflammation Suppression, Angiogenesis Promotion, Oxidative Stress Inhibition, Neurogenesis Induction, MMPs Regulation, and Remyelination

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