| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2000PNAS...97.6687S |
| P356 | DOI | 10.1073/PNAS.110146697 |
| P932 | PMC publication ID | 18703 |
| P698 | PubMed publication ID | 10829070 |
| P5875 | ResearchGate publication ID | 12489202 |
| P50 | author | Lewis C. Cantley | Q5017731 |
| P2093 | author name string | H Wu | |
| R K Humphries | |||
| T F Tedder | |||
| M Simon | |||
| C A Lowell | |||
| A Tarakhovsky | |||
| O N Witte | |||
| M Leitges | |||
| C D Helgason | |||
| A B Satterthwaite | |||
| D Fruman | |||
| F Willis | |||
| P Kanchanastit | |||
| R Lesche | |||
| P2860 | cites work | A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals | Q24647322 |
| Inhibition of the B cell by CD22: a requirement for Lyn | Q24647368 | ||
| Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases | Q28118717 | ||
| Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase | Q28141473 | ||
| Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1 | Q28143947 | ||
| Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior | Q28252722 | ||
| Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection | Q28270723 | ||
| Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes | Q28271869 | ||
| Regulation of Btk function by a major autophosphorylation site within the SH3 domain | Q28278818 | ||
| CD22 is a negative regulator of B-cell receptor signalling | Q28302610 | ||
| Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes | Q28508338 | ||
| Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
| Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development | Q28509298 | ||
| Hyperresponsive B cells in CD22-deficient mice | Q28510573 | ||
| Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation | Q28584704 | ||
| Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems | Q28586004 | ||
| PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway | Q28588309 | ||
| Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice | Q28589329 | ||
| Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice | Q28589721 | ||
| Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span | Q28590421 | ||
| A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice | Q28592432 | ||
| Immunodeficiency in protein kinase cbeta-deficient mice | Q28616043 | ||
| Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization | Q28616251 | ||
| Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting | Q29614543 | ||
| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 | ||
| The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C | Q30047790 | ||
| Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase | Q30193097 | ||
| X-linked immune deficiency (xid) of CBA/N mice | Q68798401 | ||
| Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice | Q71800467 | ||
| Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease | Q71806455 | ||
| Impaired Fas response and autoimmunity in Pten+/- mice | Q73019160 | ||
| Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation | Q73574914 | ||
| Epistatic modifiers of autoimmunity in a murine model of lupus nephritis | Q78257965 | ||
| Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop | Q78257977 | ||
| Discordant phenotype in siblings with X-linked agammaglobulinemia | Q30444636 | ||
| Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells | Q32066435 | ||
| The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation | Q33707690 | ||
| Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases | Q33729893 | ||
| A screen for genes that function downstream of Ras1 during Drosophila eye development. | Q33967357 | ||
| T cell-independent antigens type 2. | Q34300069 | ||
| Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse | Q34344768 | ||
| A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains | Q34436541 | ||
| The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain | Q34478032 | ||
| RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development | Q36303172 | ||
| Synergistic genetic defect in B-lymphocyte function. I. Defective responses to B-cell stimulants and their genetic basis | Q36343290 | ||
| Involvement of p59fynT in interleukin-5 receptor signaling | Q36365319 | ||
| Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways | Q36404181 | ||
| B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. | Q36560174 | ||
| Btk dosage determines sensitivity to B cell antigen receptor cross-linking | Q36720312 | ||
| CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling | Q36720512 | ||
| Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. | Q36781000 | ||
| Genetic identification of two major modifier loci of polycystic kidney disease progression in pcy mice | Q37373347 | ||
| Random mutagenesis screen for dominant behavioral mutations in mice | Q38553450 | ||
| Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. | Q40937465 | ||
| CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation | Q40950543 | ||
| Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals | Q41037034 | ||
| SHIP modulates immune receptor responses by regulating membrane association of Btk. | Q41042940 | ||
| Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase | Q41078571 | ||
| Constitutive membrane association potentiates activation of Bruton tyrosine kinase | Q41087272 | ||
| Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit | Q41090124 | ||
| The complexity of signaling pathways activated by the BCR. | Q41514660 | ||
| Role of Btk in B cell development and signaling | Q41587188 | ||
| The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling | Q42462089 | ||
| Defective platelet activation in G alpha(q)-deficient mice. | Q42547684 | ||
| A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion | Q43826446 | ||
| Btk function in B cell development and response. | Q45939727 | ||
| Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. | Q46027909 | ||
| Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. | Q52052343 | ||
| Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1. | Q52172388 | ||
| CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. | Q52198671 | ||
| Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. | Q52533403 | ||
| Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. | Q52533405 | ||
| Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. | Q53957276 | ||
| CD22 regulates thymus-independent responses and the lifespan of B cells. | Q55066830 | ||
| High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Q58378937 | ||
| Counterregulation by the Coreceptors CD19 and CD22 of MAP Kinase Activation by Membrane Immunoglobulin | Q58419188 | ||
| Surface IgM-stimulated proliferation, inositol phospholipid hydrolysis, Ca2+ flux, and tyrosine phosphorylation are not altered in B cells from p59fyn-1- mice | Q63445296 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 6687-6692 | |
| P577 | publication date | 2000-06-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase | |
| P478 | volume | 97 |
| Q33849420 | A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels |
| Q83727207 | A sensitised mutagenesis screen in the mouse to explore the bovine genome: study of muscle characteristics |
| Q50066279 | Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus |
| Q43754794 | CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation |
| Q34577064 | CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction |
| Q33602552 | Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer |
| Q44321741 | Loss of a single allele of SHIP exacerbates the immunopathology of Pten heterozygous mice |
| Q35782565 | Mechanisms of resistance to STI571 (Imatinib) in Philadelphia-chromosome positive acute lymphoblastic leukemia |
| Q36907698 | Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus |
| Q33897729 | Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes |
| Q34159611 | RETRACTED: Silencing of B cell receptor signals in human naive B cells |
| Q57943545 | Regulation of B lymphocytes in health and disease |
| Q40723397 | Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase |
| Q40659027 | Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study |
| Q30168571 | Signaling network of the Btk family kinases |
| Q30488141 | Spatiotemporal patterning during T cell activation is highly diverse |
| Q34282327 | Tec kinases: modulators of lymphocyte signaling and development |
| Q21195261 | The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells |
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