Intestinal microbiota: shaping local and systemic immune responses

scientific article published on 16 December 2011

Intestinal microbiota: shaping local and systemic immune responses is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.SMIM.2011.11.008
P932PMC publication ID3292882
P698PubMed publication ID22178452
P5875ResearchGate publication ID51897027

P50authorYasmine BelkaidQ28843432
Nicolas BouladouxQ43249919
P2093author name stringMichael J Molloy
P2860cites workBeta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6Q22010648
Diversity of the human intestinal microbial floraQ24544241
Symbiotic bacteria direct expression of an intestinal bactericidal lectinQ24644003
Innate immunity and intestinal microbiota in the development of Type 1 diabetesQ24647312
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestineQ24648636
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune systemQ24680733
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiotaQ27334139
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Toll-like receptorsQ27860671
Induction of intestinal Th17 cells by segmented filamentous bacteriaQ28131638
Microbial-gut interactions in health and disease. Antibiotic-associated diarrhoeaQ28259833
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
Aberrant expansion of segmented filamentous bacteria in IgA-deficient gutQ28505481
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43Q28509150
TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in miceQ28513789
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tractQ28587612
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaQ28594441
Bacterial community variation in human body habitats across space and timeQ29547432
Ecological and evolutionary forces shaping microbial diversity in the human intestineQ29547586
Induction of colonic regulatory T cells by indigenous Clostridium speciesQ29547701
A microbial symbiosis factor prevents intestinal inflammatory diseaseQ29614263
Experimental inflammatory bowel disease: insights into the host-microbiota dialogQ37857437
Intestinal microbiota promote enteric virus replication and systemic pathogenesisQ39306213
Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression.Q40961532
An ecological and evolutionary perspective on human-microbe mutualism and diseaseQ29614265
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismQ29614266
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune systemQ29614267
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cellsQ29614271
The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responsesQ29614273
Molecular analysis of commensal host-microbial relationships in the intestineQ29614776
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysQ29614839
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidQ29615586
Essential autocrine regulation by IL-21 in the generation of inflammatory T cellsQ29616147
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsQ29616148
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitisQ29616155
Interactions between commensal intestinal bacteria and the immune systemQ29617039
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protectionQ29618129
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidQ29619479
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiotaQ29619977
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of miceQ29622850
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cellsQ30476839
Exploitation of the intestinal microflora by the parasitic nematode Trichuris murisQ30524457
A key role of dendritic cells in probiotic functionalityQ30830505
Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagementQ33265418
Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of EnterobacteriaceaeQ33306722
Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-kappaB activationQ33356616
Development of allergic airway disease in mice following antibiotic therapy and fungal microbiota increase: role of host genetics, antigen, and interleukin-13Q33557513
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infectionQ33624096
Oral tolerance in the absence of naturally occurring TregsQ33840440
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fateQ33908130
Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitisQ33966409
Generation of gut-homing IgA-secreting B cells by intestinal dendritic cellsQ34000967
Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune systemQ34000988
Immune adaptations that maintain homeostasis with the intestinal microbiotaQ34100501
Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitisQ34187114
Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy.Q34321946
Activation of toll-like receptor 9 by DNA from different bacterial speciesQ34334265
Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrinQ34424372
Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and metaanalysisQ34502210
Effect of antimicrobial agents on the ecological balance of human microfloraQ34547828
Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cellsQ34557118
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulationQ34580976
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancerQ34729938
Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunityQ41171975
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammationQ41762357
Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligandsQ41851529
Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like diseaseQ41875117
Lack of oral tolerance in C3H/HeJ miceQ41996317
Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegmentQ42019085
Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteriaQ42021859
The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance inductionQ42442755
Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis.Q42747710
The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.Q42965640
Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acidQ43058014
Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditionsQ45058656
Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cellsQ45304815
Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation.Q46099764
ATP drives lamina propria T(H)17 cell differentiationQ46419573
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.Q46564597
Lactobacillus fermentum ACA-DC 179 displays probiotic potential in vitro and protects against trinitrobenzene sulfonic acid (TNBS)-induced colitis and Salmonella infection in murine modelsQ46852650
Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription 3 activityQ46952190
Crohn's disease is associated with a toll-like receptor-9 polymorphismQ47243561
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.Q48819558
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.Q50079058
Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.Q50530610
Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches.Q51769095
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.Q52590127
Gram-negative bacteria aggravate murine small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii.Q52928766
Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression.Q54412643
Impaired regulatory T cell function in germ-free miceQ56901969
Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuitsQ57128380
Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signalingQ57227671
Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina PropriaQ57339886
Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthmaQ59054619
Lipopolysaccharide (LPS) regulation of the immune response: LPS influence on oral tolerance inductionQ70566320
Lipopolysaccharide (LPS) regulation of the immune response: LPS converts germfree mice to sensitivity to oral tolerance inductionQ72112626
Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestineQ77373865
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cellsQ78806915
Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous systemQ80102518
Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cellsQ80559744
Lactobacillus Acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokinesQ80657027
Dendritic cells in germ-free and specific pathogen-free mice have similar phenotypes and in vitro antigen presenting functionQ81073587
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responsesQ81305086
Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammationQ81617509
Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in miceQ82703707
Oral toleranceQ83849376
Microbiota regulates immune defense against respiratory tract influenza A virus infectionQ34750186
Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surfaceQ35008436
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice.Q35105043
A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunityQ35208406
Peripheral education of the immune system by colonic commensal microbiota.Q35341308
Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in miceQ35568115
Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 productionQ35644280
The fundamental basis of inflammatory bowel diseaseQ35649436
CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cellsQ35776179
Deletion of TLR5 results in spontaneous colitis in miceQ36138027
Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alphaQ36151999
The role of retinoic acid in tolerance and immunityQ36162881
Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation?Q36209726
The 'microflora hypothesis' of allergic diseasesQ36360555
Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.Q36362779
Successful transmission of a retrovirus depends on the commensal microbiotaQ36460257
Feeding our immune system: impact on metabolismQ36494499
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammationQ36563545
Nod-like proteins in immunity, inflammation and diseaseQ36655897
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cellsQ36699777
Debugging how bacteria manipulate the immune response.Q36739044
Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosaQ36813569
Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responsesQ37267529
Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cellsQ37339787
Gut commensal bacteria direct a protective immune response against Toxoplasma gondii.Q37353312
Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity.Q37401744
Regulatory T cells in the control of host-microorganism interactions (*).Q37419387
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.Q37428976
Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor?Q37493607
Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responsesQ37581953
The development of intestinal lymphoid tissues at the interface of self and microbiotaQ37594569
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis.Q37627550
Bacterial flagellin is a dominant antigen in Crohn disease.Q37698878
Toll-like receptor driven B cell activation in the induction of systemic autoimmunityQ37838577
P433issue1
P921main subjectsystemic immune responseQ106570166
P304page(s)58-66
P577publication date2011-12-16
P1433published inSeminars in ImmunologyQ15762658
P1476titleIntestinal microbiota: shaping local and systemic immune responses
P478volume24

Reverse relations

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