A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology

scientific article published on 14 October 2015

A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1039247S
P356DOI10.1371/JOURNAL.PONE.0139247
P932PMC publication ID4605789
P698PubMed publication ID26465152
P5875ResearchGate publication ID283240298

P2093author name stringAndre C Kalil
Diana F Florescu
Lucile E Wrenshall
R Brian Stevens
Kirk W Foster
Clifford D Miles
John P Sandoz
Theodore H Rigley
Tamer Malik
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Late Calcineurin Inhibitor Withdrawal Prevents Progressive Left Ventricular Diastolic Dysfunction in Renal Transplant RecipientsQ57789840
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Is it safe to withdraw steroids within seven days of renal transplantation?Q34448543
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Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trialQ42466678
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Sirolimus-based calcineurin inhibitor withdrawal immunosuppressive regimen in kidney transplantation: a single center experienceQ43128472
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Chronic calcineurin inhibitor nephrotoxicity-lest we forgetQ43759235
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Long-term deterioration of kidney allograft functionQ46485576
A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipients--an interim analysisQ46485598
Optimal dose and target trough level in cyclosporine and tacrolimus conversion in renal transplantation as evaluated by lymphocyte drug sensitivity and pharmacokinetic parametersQ46512737
Sirolimus in combination with tacrolimus is associated with worse renal allograft survival compared to mycophenolate mofetil combined with tacrolimusQ46645995
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectimmunosuppressionQ1455316
P304page(s)e0139247
P577publication date2015-10-14
P1433published inPLOS OneQ564954
P1476titleA Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology
P478volume10

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cites work (P2860)
Q40125813A Double-Blind, Double-Dummy, Flexible-Design Randomized Multicenter Trial: Early Safety of Single- Versus Divided-Dose Rabbit Anti-Thymocyte Globulin Induction in Renal Transplantation
Q30239091Polyclonal and monoclonal antibodies for induction therapy in kidney transplant recipients.
Q49724077Tailored Rabbit Antithymocyte Globulin Induction Dosing for Kidney Transplantation

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