Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice

scientific article published on 14 October 2015

Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1040173S
P356DOI10.1371/JOURNAL.PONE.0140173
P932PMC publication ID4605611
P698PubMed publication ID26465326
P5875ResearchGate publication ID283671075

P50authorBastian SchirmerQ60971596
P2093author name stringDirk Wedekind
Detlef Neumann
Silke Glage
P2860cites workNLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling.Q54194314
A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune DiseaseQ57232080
IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr miceQ60998067
Dichotomic effects of IFN-gamma on the development of systemic lupus erythematosus-like syndrome in MRL-lpr / lpr miceQ64388661
Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosusQ73086329
Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18Q74477197
A critical role for IL-18 in the proliferation and activation of NK1.1+ CD3- cellsQ74557513
Increased IL-18 in patients with systemic lupus erythematosus: relations with Th-1, Th-2, pro-inflammatory cytokines and disease activity. IL-18 is a marker of disease activity but does not correlate with pro-inflammatory cytokinesQ74602787
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma productionQ77367658
Correlation of renal tubular epithelial cell-derived interleukin-18 up-regulation with disease activity in MRL-Faslpr mice with autoimmune lupus nephritisQ78505529
Injection of IL-12- and IL-18-encoding plasmids ameliorates the autoimmune pathology of MRL/Mp-Tnfrsf6lpr mice: synergistic effect on autoimmune symptomsQ79319535
Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammationQ80102514
Interleukin-18 receptor signaling is not required for autoantibody production and end-organ disease in murine lupusQ81484695
High circulating levels of interleukin-18 binding protein indicate the severity of glomerular involvement in systemic lupus erythematosusQ84311481
IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune diseaseQ33715791
The inflammasome and lupus: another innate immune mechanism contributing to disease pathogenesis?Q34127758
Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysisQ34478393
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Q34566135
Association of interleukin-18 (-137G/C) polymorphism with rheumatoid arthritis and systemic lupus erythematosus: a meta-analysisQ34893105
Targeting transcription factor Stat4 uncovers a role for interleukin-18 in the pathogenesis of severe lupus nephritis in miceQ35393618
The genetics of human systemic lupus erythematosusQ35575146
Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strainsQ36342054
Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr miceQ36351961
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupusQ36403146
Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injuryQ36977361
Interleukin-18 and IL-18 binding proteinQ37220336
Roles of interferon-gamma and interleukin-4 in murine lupusQ37365961
Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr miceQ37377479
The role of IL-23/IL-17 axis in lupus nephritisQ37397437
Cutaneous lupus erythematosus: recent lessons from animal modelsQ37778643
Cytokine inhibition as a strategy for treating systemic lupus erythematosusQ38064143
The role of cytokines in the pathogenesis of systemic lupus erythematosus - from bench to bedsideQ38085723
IL-18 in inflammatory and autoimmune diseaseQ38124723
Interleukin-18, more than a Th1 cytokineQ38166154
IL-37 inhibits IL-18-induced tubular epithelial cell expression of pro-inflammatory cytokines and renal ischemia-reperfusion injuryQ38957793
Interleukin-12 upregulates the IL-18Rbeta chain in BALB/c thymocytesQ40780323
Lymphocytes from autoimmune MRL lpr/lpr mice are hyperresponsive to IL-18 and overexpress the IL-18 receptor accessory chainQ40822216
Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis.Q41509132
Defective NK cell activity and Th1 response in IL-18-deficient miceQ43595287
Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysisQ44130510
Blockade of IL-18 receptor signaling delays the onset of autoimmune disease in MRL-Faslpr miceQ45094809
IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.Q45933733
Control of animal pain and distress in cancer and toxicologic researchQ46727769
Elevated interleukin-18 levels correlated with disease activity in systemic lupus erythematosusQ47417555
IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) miceQ47909571
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectkidney failureQ476921
P304page(s)e0140173
P577publication date2015-10-14
P1433published inPLOS OneQ564954
P1476titleDeletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice
P478volume10

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cites work (P2860)
Q55401570Analysis of Serum Interleukin (IL)-1β and IL-18 in Systemic Lupus Erythematosus.
Q33893588Control of lupus nephritis by changes of gut microbiota.