Role of COX-2 inhibitors in cancer therapy

scientific article published on January 2004

Role of COX-2 inhibitors in cancer therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1081/CNV-120030216
P698PubMed publication ID15199610

P2093author name stringCharles Blanke
P2860cites workDepth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinomaQ73862914
Is the COX-2 effect on accelerated hematopoiesis mediated by prostaglandin E2?Q74043281
Radiation induces upregulation of cyclooxygenase-2 (COX-2) protein in PC-3 cellsQ74272756
Cyclooxygenase regulates angiogenesis induced by colon cancer cellsQ24336248
Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptorsQ24648434
Arachidonic acid metabolismQ28287622
Aspirin use and chronic diseases: a cohort study of the elderlyQ28341614
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)Q28586461
Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet AggregationQ28622645
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesisQ29547178
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposisQ29616121
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety StudyQ29620671
Prostaglandin endoperoxide synthase gene structure: identification of the transcriptional start site and 5'-flanking regulatory sequencesQ31111891
Adrenergic stimulation of osteoclastogenesis mediated by expression of osteoclast differentiation factor in MC3T3-E1 osteoblast-like cellsQ32139468
Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosisQ33180353
Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virusQ33806129
Risk of cardiovascular events associated with selective COX-2 inhibitorsQ34087109
Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.Q34132261
Cyclooxygenase-2: a target for the prevention and treatment of breast cancerQ34277077
The role of cyclooxygenase-2 in prostate cancerQ34335675
Cyclooxygenase-2 (COX-2) enzyme inhibitors as potential enhancers of tumor radioresponseQ34418299
Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposisQ34729756
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenicQ35163045
Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting.Q35842152
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and painQ35953747
Mechanism of inhibition of tumour growth by aspirin and indomethacinQ36042640
Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potentialQ36085224
Colorectal cancer prevention by non-steroidal anti-inflammatory drugs: effects of dosage and timingQ36641159
Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancerQ36641883
Structure of the human cyclo-oxygenase-2 geneQ36725123
Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.Q37366851
Targeting angiogenic processes by combination rofecoxib and ionizing radiationQ39414041
Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritisQ39765865
Induction of apoptosis by cyclooxygenase-2 inhibitors in prostate cancer cell linesQ40794085
The role of cyclooxygenase enzymes in the growth of human gall bladder cancer cellsQ40870787
Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer preventionQ40919512
Effects of transforming growth factor beta and interleukin-1 beta on expression of cyclooxygenase 1 and 2 and phospholipase A2 mRNA in lung fibroblasts and endothelial cells in cultureQ41507875
Cyclooxygenase-2 inhibitors: a new class of anti-inflammatory agents that spare the gastrointestinal tractQ41537389
Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesisQ41709477
Cyclooxygenase-2 expression in Helicobacter pylori-associated premalignant and malignant gastric lesionsQ42094376
Inhibition by aspirin of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced bladder carcinogenesis and enhancement of forestomach carcinogenesisQ42255167
Immunohistochemical expression of cyclooxygenase-2 in skin cancersQ42505683
Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac.Q43557993
Prostaglandin E2 increases growth and motility of colorectal carcinoma cellsQ43559615
Platelet-derived growth factor stimulates phospholipase C-gamma 1, extracellular signal-regulated kinase, and arachidonic acid release in rat myometrial cells: contribution to cyclic 3',5'-adenosine monophosphate production and effect on cell prolifQ43683552
Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitorQ43700532
Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cellsQ43726282
Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicityQ43757544
The relationship between cyclooxygenase-2 expression and colorectal cancer.Q44193470
Alteration of tumor growth by aspirin and indomethacin: studies with two transplantable tumors in mouseQ45076575
Relation between cyclooxygenase-2 expression and tumor invasiveness and patient survival in transitional cell carcinoma of the urinary bladder.Q52059420
Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm.Q53395387
A comparison of the effects of the prostaglandin synthesis inhibitors indomethacin and carprofen on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis in rats fed different amounts of essential fatty acid.Q53514245
Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis.Q54647090
Sulindac for polyposis of the colon.Q54736921
A protective effect of sulindac against chemically-induced primary colonic tumours in mice.Q54738047
Interleukin-1-Induced Prostaglandin E2 Biosynthesis in Human Synovial Cells Involves the Activation of Cytosolic Phospholipase A2 and Cyclooxygenase-2Q60321344
Preliminary report: Findings from the aspirin component of the ongoing Physicians' Health StudyQ68123711
Effects of Long-term Sulindac Therapy on Colonic PolyposisQ68263361
Effects of various prostaglandin synthesis inhibitors on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amineQ68723914
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2Q70787131
PGE2 and angiogenesisQ70898171
Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamineQ70958000
Phospholipid precursors of prostaglandinsQ72217755
Regulation of cyclooxygenase-2 by interferon gamma and transforming growth factor alpha in normal human epidermal keratinocytes and squamous carcinoma cells. Role of mitogen-activated protein kinasesQ73041199
Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancerQ73432823
Expression of cyclooxygenase-2 in human gastric adenomas and adenocarcinomasQ73552652
P433issue2
P304page(s)271-282
P577publication date2004-01-01
P1433published inCancer InvestigationQ325953
P1476titleRole of COX-2 inhibitors in cancer therapy
P478volume22

Reverse relations

cites work (P2860)
Q37036925Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma
Q39949862NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure.
Q22299231Preadministration of High-Dose Salicylates, Suppressors of NF- B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation Therapy
Q90401790Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition
Q38944686The impact of COX-2 on invasion of osteosarcoma cell and its mechanism of regulation

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