Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity

scientific article published on 9 March 2015

Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ACSCHEMNEURO.5B00010
P932PMC publication ID4489556
P698PubMed publication ID25746685
P5875ResearchGate publication ID273326901

P50authorAmy R DunnQ58588226
Kristen A StoutQ82243216
Gary W. MillerQ38322030
P2093author name stringAli Salahpour
Kelly M Lohr
Minzheng Wang
Thomas S Guillot
P2860cites workTyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease.Q64856368
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Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transportQ28301517
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VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicityQ28512294
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Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine.Q30432694
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Lobeline inhibits the neurochemical and behavioral effects of amphetamine.Q31963453
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Lobelane inhibits methamphetamine-evoked dopamine release via inhibition of the vesicular monoamine transporter-2.Q33613631
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Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosisQ33862898
Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration : early loss of TH in striosomes after methamphetamine.Q33873281
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Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivoQ33919548
Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis.Q33961999
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Dopamine is not essential for the development of methamphetamine-induced neurotoxicity.Q35071086
Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone.Q35128313
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Multiple hit hypotheses for dopamine neuron loss in Parkinson's diseaseQ36785396
PACAP38 increases vesicular monoamine transporter 2 (VMAT2) expression and attenuates methamphetamine toxicity.Q36942673
Altered vesicular dopamine storage in Parkinson's disease: a premature demiseQ37159961
Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neuronsQ37180671
Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neuronsQ37406074
N-terminus regulation of VMAT2 mediates methamphetamine-stimulated effluxQ37589110
Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine.Q39758343
Vesicular monoamine transporter 2 regulates the sensitivity of rat dopaminergic neurons to disturbed cytosolic dopamine levels.Q40047308
Dopamine quinones activate microglia and induce a neurotoxic gene expression profile: relationship to methamphetamine-induced nerve ending damageQ40208477
Peroxynitrite inactivates the human dopamine transporter by modification of cysteine 342: potential mechanism of neurotoxicity in dopamine neurons.Q40728188
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Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter.Q42541545
Inhibitors of Na(+)/H(+) and Na(+)/Ca(2+) exchange potentiate methamphetamine-induced dopamine neurotoxicity: possible role of ionic dysregulation in methamphetamine neurotoxicityQ43627948
Increased risk of Parkinson's disease in individuals hospitalized with conditions related to the use of methamphetamine or other amphetamine-type drugsQ43959363
Methamphetamine rapidly decreases mouse vesicular dopamine uptake: role of hyperthermia and dopamine D2 receptorsQ44519185
3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesisQ44616102
Methamphetamine-induced deficits of brain monoaminergic neuronal markers: distal axotomy or neuronal plasticityQ44654013
Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity.Q44842402
Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activationQ44911128
Differential abundance of superoxide dismutase in interneurons versus projection neurons and in matrix versus striosome neurons in monkey striatumQ45292366
Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action.Q46083768
Methamphetamine-induced conditioned place preference or aversion depending on dose and presence of drugQ46404583
Methamphetamine neurotoxicity involves vacuolation of endocytic organelles and dopamine-dependent intracellular oxidative stress.Q48144142
The chromaffin granule and synaptic vesicle amine transporters differ in substrate recognition and sensitivity to inhibitors.Q48157604
Further studies of the role of hyperthermia in methamphetamine neurotoxicity.Q48162569
Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice.Q48257438
Is Parkinson's disease a vesicular dopamine storage disorder? Evidence from a study in isolated synaptic vesicles of human and nonhuman primate striatumQ48301354
Environmental enrichment does not reduce the rewarding and neurotoxic effects of methamphetamine.Q48314703
The effects of methamphetamine on the production of free radicals and oxidative stressQ48379473
Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice.Q48478164
The influence of environmental temperature on the transient effects of methamphetamine on dopamine levels and dopamine release in rat striatumQ48529338
Tetrabenazine-induced depletion of brain monoamines: characterization and interaction with selected antidepressantsQ48644051
Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibersQ48656676
Functional architecture of the mammalian striatum: mouse vascular and striosome organization and their anatomic relationshipsQ48842504
Amphetamine and other psychostimulants reduce pH gradients in midbrain dopaminergic neurons and chromaffin granules: a mechanism of action.Q48843310
Acute neuropathological changes in the caudate nucleus caused by MPTP and methamphetamine: immunohistochemical studiesQ48964680
Dopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brainQ48968033
Simultaneous monitoring of conditioned place preference and locomotor sensitization following repeated administration of cocaine and methamphetamine.Q51393104
Mental depression in hypertensive patients treated for long periods with large doses of reserpine.Q52173297
P433issue5
P304page(s)790-799
P577publication date2015-03-09
P1433published inACS Chemical NeuroscienceQ2819059
P1476titleIncreased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity
P478volume6

Reverse relations

cites work (P2860)
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Q64785696The usual suspects, dopamine and alpha-synuclein, conspire to cause neurodegeneration
Q41031814Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals.

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