A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer

scientific article published on 6 May 2015

A Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-14-3655
P932PMC publication ID4490130
P698PubMed publication ID25948588

P50authorAnn M BodeQ91173532
Zigang DongQ91798724
Hanyong ChenQ114735035
Sang Kwon SeoQ114735062
Joe Eun SonQ114735069
Jong Rhan KimQ114735074
P2093author name stringEunjung Lee
Jong-Eun Kim
Dong Joon Kim
Ki Won Lee
Tae Gyu Lim
Hyein Jeong
P2860cites work2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cellsQ39217585
2′-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activationQ39646481
PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosisQ39800095
Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.Q39885745
Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cellsQ40080766
2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer in vitro and in vivo in a rat tumor modelQ43120603
Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological propertiesQ43788429
Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper siteQ44997396
Antitumor activity of 2-hydroxycinnamaldehyde for human colon cancer cells through suppression of β-catenin signalingQ45747245
Pharmacokinetic study of cinnamaldehyde in rats by GC-MS after oral and intravenous administration.Q45816571
Water-soluble polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic tumor cell linesQ46777835
Modern TCM: Enter the clinicQ47240344
Traditional Asian medicineQ47240412
Anti-Pim-1 mAb inhibits activation and proliferation of T lymphocytes and prolongs mouse skin allograft survivalQ85046649
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levelsQ24309167
PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancersQ24603099
Docking study yields four novel inhibitors of the protooncogene Pim-1 kinaseQ27649900
XDSQ27860472
Overview of the CCP4 suite and current developmentsQ27860782
REFMAC5 for the refinement of macromolecular crystal structuresQ27860905
Phasercrystallographic softwareQ27860930
Towards a knowledge-based Human Protein AtlasQ29617987
Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potentialQ30495171
Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cellsQ33289709
Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1Q33639024
Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetesQ33979747
Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplicationQ34990221
Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signalingQ35018349
Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cellsQ35571648
In vivo analysis of Pim-1 deficiencyQ35859661
Signal transduction pathways in cancer development and as targets for cancer preventionQ36226855
Functional role and therapeutic potential of the pim-1 kinase in colon carcinomaQ36945939
PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosisQ37073702
Molecular targets of phytochemicals for cancer preventionQ37843462
Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis.Q37847673
The Pim kinases: new targets for drug developmentQ37903357
Insights from Pim1 structure for anti-cancer drug design.Q38045948
Pim kinases in cancer: diagnostic, prognostic and treatment opportunitiesQ38049911
2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivationQ38301647
P4510describes a project that usesImageJQ1659584
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectskin cancerQ192102
natural productQ901227
P304page(s)2716-2728
P577publication date2015-05-06
P1433published inCancer ResearchQ326097
P1476titleA Novel Cinnamon-Related Natural Product with Pim-1 Inhibitory Activity Inhibits Leukemia and Skin Cancer
P478volume75

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cites work (P2860)
Q580937502'-Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via STAT3 inactivation and ROS generation
Q49684565Anticarcinogenic Effect of Spices Due to Phenolic and Flavonoid Compounds-In Vitro Evaluation on Prostate Cells
Q37046675Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase
Q91801799Chitosan/Essential Oils Formulations for Potential Use as Wound Dressing: Physical and Antimicrobial Properties
Q38739101Cinnamaldehydes in Cancer Chemotherapy.
Q90068431Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials
Q92919053Orobol, an Enzyme-Convertible Product of Genistein, exerts Anti-Obesity Effects by Targeting Casein Kinase 1 Epsilon
Q48274324Osajin Inhibits Solar UV-Induced Cyclooxygenase-2 Expression Through Direct Inhibition of RSK2.
Q90402226Reduced pim-1 expression increases chemotherapeutic drug sensitivity in human androgen-independent prostate cancer cells by inducing apoptosis
Q26741169Spices for Prevention and Treatment of Cancers
Q46973951Thyroid hormone inhibits growth of hepatoma cells through induction of miR-214.

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