Protective effect of a Protein Epitope Mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation

scientific article published on 27 June 2015

Protective effect of a Protein Epitope Mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1016720297
P356DOI10.1186/S12931-015-0231-5
P932PMC publication ID4490744
P698PubMed publication ID26112287
P5875ResearchGate publication ID279302734

P2093author name stringEric Chevalier
François Daubeuf
Françoise Jung
Garry J Douglas
Nelly Frossard
P2860cites workIdentification of a novel chemokine (CCL28), which binds CCR10 (GPR2)Q22253984
CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cellsQ24684754
A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissuesQ28137982
Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkineQ28139210
Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)Q28139219
CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activityQ28204353
CCL27-CCR10 interactions regulate T cell-mediated skin inflammationQ28217086
Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammationQ28305039
The design, structures and therapeutic potential of protein epitope mimetics.Q30371623
Role of viral respiratory infections in asthma and asthma exacerbationsQ34275483
Immune pathways for translating viral infection into chronic airway disease.Q34440425
Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasiaQ36229077
Dendritic cells, viruses, and the development of atopic diseaseQ36340296
Targeting eosinophil biology in asthma therapyQ37862880
Asthma exacerbations: origin, effect, and prevention.Q37963565
CCR10 and its ligands in regulation of epithelial immunity and diseasesQ38017619
IL-17A induces CCL28, supporting the chemotaxis of IgE-secreting B cellsQ39568602
IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFkappaB-dependent pathwayQ40297261
Acute Asthma Models to Ovalbumin in the MouseQ40841697
Inflammation of the respiratory tract is associated with CCL28 and CCR10 expression in a murine model of allergic asthmaQ47690537
CCL28 involvement in mucosal tissues protection as a chemokine and as an antibacterial peptideQ50002981
Performing Bronchoalveolar Lavage in the Mouse.Q54331613
Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmographyQ73730758
Th2 differentiation in distinct lymph nodes influences the site of mucosal Th2 immune-inflammatory responsesQ80819724
Safety and efficacy of an oral CCR3 antagonist in patients with asthma and eosinophilic bronchitis: a randomized, placebo-controlled clinical trialQ86861295
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)77
P577publication date2015-06-27
P1433published inRespiratory ResearchQ7315904
P1476titleProtective effect of a Protein Epitope Mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation
P478volume16

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cites work (P2860)
Q39025261A pathway-based association study reveals variants from Wnt signalling genes contributing to asthma susceptibility
Q37694678CCR10/CCL27 crosstalk contributes to failure of proteasome-inhibitors in multiple myeloma
Q64126689Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H. Pylori Infection
Q90274829Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium
Q97422053Distinct type 2-high inflammation associated molecular signatures of chronic rhinosinusitis with nasal polyps with comorbid asthma
Q47643277Microarray analysis of lung long non-coding RNAs in cigarette smoke-exposed mouse model
Q39097223Mucosal immune tolerance at the ocular surface in health and disease
Q33638746POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease
Q36101572Precursor B Cells Increase in the Lung during Airway Allergic Inflammation: A Role for B Cell-Activating Factor
Q55155725The chemokine receptor CCR10 promotes inflammation-driven hepatocarcinogenesis via PI3K/Akt pathway activation.

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