The rational design and development of a dual chamber vaginal/rectal microbicide gel formulation for HIV prevention.

scientific article published on 17 June 2015

The rational design and development of a dual chamber vaginal/rectal microbicide gel formulation for HIV prevention. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.ANTIVIRAL.2015.06.010
P932PMC publication ID4492852
P698PubMed publication ID26093158

P50authorCharlene S DezzuttiQ55298106
Robert W BuckheitQ114435506
P2093author name stringDavid F Katz
Jennifer J Peters
Karen W Buckheit
Anthony S Ham
Sean T Nugent
Ashlee D Boczar
Cory M Shelter
P2860cites workIs wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activityQ21133918
Frequent use of lubricants for anal sex among men who have sex with men: the HIV prevention potential of a microbicidal gelQ24544056
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in womenQ24629582
Global epidemiology of HIV infection in men who have sex with menQ28271559
Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type-1-specific compounds related to oxathiin carboxanilideQ28378796
In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicideQ28472968
Development of HIV-1 rectal-specific microbicides and colonic tissue evaluationQ28540761
Preexposure prophylaxis for HIV infection among African womenQ29620077
Assessing microbicide acceptability: a comprehensive and integrated approach.Q30362581
Development of a combination microbicide gel formulation containing IQP-0528 and tenofovir for the prevention of HIV infectionQ30411459
Tenofovir-based preexposure prophylaxis for HIV infection among African womenQ30621914
Vaginal deployment and tenofovir delivery by microbicide gelsQ30647900
A vaginal fluid simulantQ33653706
Acceptability of UC781 gel as a rectal microbicide among HIV-uninfected women and men.Q33833859
Per-contact risk of human immunodeficiency virus transmission between male sexual partnersQ33869711
Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitroQ34025707
A review of the physical and chemical properties of human semen and the formulation of a semen simulantQ34426459
Order of orifices: sequence of condom use and ejaculation by orifice during anal intercourse among women: implications for HIV transmissionQ34440636
Heterosexual anal intercourse among community and clinical settings in Cape Town, South AfricaQ34472243
Rectal microbicide development.Q34575590
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A phase 1 randomized, double blind, placebo controlled rectal safety and acceptability study of tenofovir 1% gel (MTN-007).Q34661892
Rectal microbicides: clinically relevant approach to the design of rectal specific placebo formulationsQ34704317
Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1.Q34737582
Women's anal sex practices: implications for formulation and promotion of a rectal microbicideQ34773756
Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004)Q35012567
Rectal microbicides: can we make them and will people use them?Q35012572
Effects of sodium concentration and osmolality on water and electrolyte absorption from the intact human colonQ35571754
The slippery slope: lubricant use and rectal sexually transmitted infections: a newly identified riskQ35629984
AIDS in America--forgotten but not goneQ36057723
Reformulated tenofovir gel for use as a dual compartment microbicide.Q36159765
RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarateQ36359092
Comparative evaluation of virus transmission inhibition by dual-acting pyrimidinedione microbicides using the microbicide transmission and sterilization assayQ36803970
Preference for gel over suppository as delivery vehicle for a rectal microbicide: results of a randomised, crossover acceptability trial among men who have sex with men.Q37159238
Anal intercourse among young heterosexuals in three sexually transmitted disease clinics in the United StatesQ37249738
The structure-activity relationships of 2,4(1H,3H)-pyrimidinedione derivatives as potent HIV type 1 and type 2 inhibitorsQ40042904
Comparative evaluation of the inhibitory activities of a series of pyrimidinedione congeners that inhibit human immunodeficiency virus types 1 and 2.Q40060575
Heterosexual anal intercourse increases risk of HIV infection among young South African men.Q46253583
Squeezing flows of vaginal gel formulations relevant to microbicide drug delivery.Q51170392
Rectal microbicide acceptability: results of a volume escalation trial.Q65002886
A study on the buffering activity of the human rectum. In vivo demonstration of HCO3- and H+ secretion after rectal application of fluids with an unphysiological pHQ69341892
Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmissionQ79687951
Permeability of tritiated water through human cervical and vaginal tissueQ80289918
In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trialsQ81352536
Sexual lubricants in South Africa may potentially disrupt mucosal surfaces and increase HIV transmission risk among men who have sex with menQ87032013
P921main subjectprevention of HIV/AIDSQ7242372
P304page(s)153-164
P577publication date2015-06-17
P1433published inAntiviral ResearchQ4775352
P1476titleThe rational design and development of a dual chamber vaginal/rectal microbicide gel formulation for HIV prevention
P478volume120

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cites work (P2860)
Q38775728Coupled gel spreading and diffusive transport models describing microbicidal drug delivery.
Q60909800Deducing Mucosal Pharmacokinetics and Pharmacodynamics of the Anti-HIV Molecule Tenofovir from Measurements in Blood
Q53751650Designing and developing suppository formulations for anti-HIV drug delivery.
Q64137772Effects of gel volume on pharmacokinetics for vaginal and rectal applications of combination DuoGel-IQB4012, a dual chamber-dual drug HIV microbicide gel, in pigtailed macaques
Q59359510Molecular Docking Studies of HIV-1 Resistance to Reverse Transcriptase Inhibitors: Mini-Review
Q36257669Multicompartmental Pharmacokinetic Model of Tenofovir Delivery to the Rectal Mucosa by an Enema
Q39356290On-demand microbicide products: design matters
Q36644657Pharmacokinetic and Pharmacodynamic Evaluation following Vaginal Application of IQB3002, a Dual-Chamber Microbicide Gel Containing the Nonnucleoside Reverse Transcriptase Inhibitor IQP-0528 in Rhesus Macaques
Q37023114Safety and Pharmacokinetics of Quick-Dissolving Polymeric Vaginal Films Delivering the Antiretroviral IQP-0528 for Preexposure Prophylaxis
Q38802457Stimuli-sensitive thiolated hyaluronic acid based nanofibers: synthesis, preclinical safety and in vitro anti-HIV activity.

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