Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors

scientific article published on 8 June 2015

Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20132100
P932PMC publication ID4493409
P698PubMed publication ID26056231

P2093author name stringMikael Sigvardsson
Tobias Strid
Josefine Åhsberg
Rajesh Somasundaram
Jonas Ungerbäck
P2860cites workUltrafast and memory-efficient alignment of short DNA sequences to the human genomeQ21183894
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Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitorsQ22010684
Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genesQ24290157
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesQ24617969
Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5Q24673653
Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell developmentQ28253137
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Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progressionQ33842740
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fateQ33961160
Stepwise reprogramming of B cells into macrophagesQ33978638
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Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.Q34116313
Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitorsQ34686624
A dose-dependent role for EBF1 in repressing non-B-cell-specific genes.Q35079594
A critical role for TCF-1 in T-lineage specification and differentiationQ35165548
Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemiaQ35213566
CCAAT/enhancer binding protein alpha (C/EBP(alpha))-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation.Q35345851
Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.Q36229473
Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcriptionQ36230026
Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.Q36300847
Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.Q36369494
Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactionsQ36399587
Transcriptional repression of Gata3 is essential for early B cell commitment.Q36876725
Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytesQ37428286
A comprehensive review of the phenotype and function of antigen-specific immunoregulatory double negative T cellsQ38036510
Failure of B-cell differentiation in mice lacking the transcription factor EBF.Q38293381
Myeloid lineage switch of Pax5 mutant but not wild-type B cell progenitors by C/EBPalpha and GATA factorsQ39804736
Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors.Q40517723
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.Q40683787
Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.Q40937465
Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent mannerQ41817710
The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesisQ41998237
Essential role of EBF1 in the generation and function of distinct mature B cell typesQ42137600
Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experimentsQ42642886
Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatinQ42826918
Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.Q43501853
Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells.Q44979321
B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cellsQ45131376
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Q45345200
Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1.Q48269882
Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.Q50749492
EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors.Q50779847
Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5.Q50876705
Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.Q52196159
Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAPQ58326934
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectheterozygosityQ124059385
P304page(s)1109-1123
P577publication date2015-06-08
P1433published inJournal of Experimental MedicineQ3186912
P1476titleCombined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors
P478volume212