Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase

scientific article published on 25 January 2007

Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2006-10-048215
P932PMC publication ID1885507
P698PubMed publication ID17255352
P5875ResearchGate publication ID6549508

P2093author name stringJudson A Brewer
Sandip Bhattacharyya
Louis J Muglia
Diane E Brown
Sherri K Vogt
P2860cites workDefective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.Q24537701
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Q28185796
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsQ28237789
Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathwayQ28270455
Antiinflammatory action of glucocorticoids--new mechanisms for old drugsQ28278037
Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1Q28366337
Innate immunity: the virtues of a nonclonal system of recognitionQ29614428
Negative regulation of toll-like receptor-mediated immune responsesQ29619019
Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study.Q51536797
Inhibition of p38 mitogen-activated protein kinase: dose-dependent suppression of leukocyte and endothelial response after endotoxin challenge in humans.Q51721285
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activationQ73886490
Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease modelsQ74138408
MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsisQ74154176
p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytesQ77732872
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokinesQ29620217
Points of control in inflammationQ29620319
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthaseQ30439838
Subnuclear trafficking and gene targeting by steroid receptorsQ33204998
Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosisQ33581637
Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell linesQ33648231
Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathwaysQ33715487
Rapid actions of steroid receptors in cellular signaling pathways.Q34135517
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzetaQ34331980
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responsesQ34479244
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenicQ35163045
Recognition of microbial infection by Toll-like receptorsQ35192575
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repressionQ35200339
Decoding transcriptional programs regulated by PPARs and LXRs in the macrophage: effects on lipid homeostasis, inflammation, and atherosclerosisQ35573332
Nuclear receptor signaling in macrophages.Q35617588
Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cellQ35666145
Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammationQ35912822
Inflammation suppressor genes: please switch out all the lightsQ36073369
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shockQ36227887
The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skinQ36326164
How Toll-like receptors signal: what we know and what we don't knowQ36339101
The many paths to p38 mitogen-activated protein kinase activation in the immune systemQ36518938
Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.Q37372701
Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptorQ38293939
LXR-dependent gene expression is important for macrophage survival and the innate immune responseQ38335500
Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemiaQ38919861
Blockade of p38 map kinase inhibits complement-induced acute lung injury in a murine modelQ39359497
Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agentQ40373664
The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.Q40482210
The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophagesQ40504212
Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophagesQ40657235
Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophagesQ40688402
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.Q40919510
Prostaglandin endoperoxide H synthases-1 and -2.Q41090404
Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.Q41812359
Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factorQ41839655
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.Q42135532
Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinaseQ42507664
Conditional gene targeting in macrophages and granulocytes using LysMcre mice.Q44554898
Expression of mitogen-activated protein kinase phosphatase 1, a negative regulator of the mitogen-activated protein kinases, in rheumatoid arthritis: up-regulation by interleukin-1beta and glucocorticoidsQ45099909
Receptor-independent activation of GABAergic neurotransmission and receptor-dependent nontranscriptional activation of phosphatidylinositol 3-kinase/protein kinase Akt pathway in short-term cardiovascular actions of dexamethasone at the nucleus tracQ45137080
Homodimerization of the glucocorticoid receptor is not essential for response element binding: activation of the phenylethanolamine N-methyltransferase gene by dimerization-defective mutantsQ46771342
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
toll-like receptorQ408004
inflammationQ101991
P304page(s)4313-4319
P577publication date2007-01-25
P1433published inBloodQ885070
P1476titleMacrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase
P478volume109

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