Direct Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase?

scientific article published on 16 March 2012

Direct Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FPHAR.2012.00030
P932PMC publication ID3306014
P698PubMed publication ID22438843
P5875ResearchGate publication ID221967738

P2093author name stringAndreas Daiber
Thomas Jansen
P2860cites workBiliverdin reductase: a major physiologic cytoprotectantQ24541497
Neural roles for heme oxygenase: contrasts to nitric oxide synthaseQ24555196
Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductaseQ24648338
Bilirubin and glutathione have complementary antioxidant and cytoprotective rolesQ24649034
Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stressQ28214376
Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycleQ28264545
Biliverdin reductase: new features of an old enzyme and its potential therapeutic significanceQ28268811
Bilirubin is an antioxidant of possible physiological importanceQ28288206
Caveolae compartmentalization of heme oxygenase-1 in endothelial cellsQ28575667
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stressQ29615436
Endothelial Protection by Pentaerithrityl Trinitrate: Bilirubin and Carbon Monoxide as Possible MediatorsQ30320593
Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate.Q30320866
The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells.Q30321196
Therapeutic targeting of mitochondrial superoxide in hypertensionQ33981734
Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertensionQ34022338
Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trialQ34403303
The jaundice of the cellQ34414397
Effects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: results of the HOPE studyQ44845974
Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?Q45142965
Bilirubin the beneficentQ45170125
Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects.Q46024791
Investigation of a possible interaction between the heme oxygenase/biliverdin reductase and nitric oxide synthase pathway in murine gastric fundus and jejunumQ46500339
AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic ratsQ46551832
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic miceQ46757550
Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failureQ46804727
Oxidative stress and cardiovascular diseasesQ46845947
Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitisQ48617060
Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease.Q48833283
Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice.Q50707608
Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia.Q51423787
Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment.Q53318203
Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.Q53536180
Antioxidative strategies in cognitive impairment: a novel connection between biliverdin-reductase and statinsQ57983933
Bilirubin Is an Effective Antioxidant of Peroxynitrite-Mediated Protein Oxidation in Human Blood PlasmaQ62665582
Antioxidant vitamin C improves endothelial dysfunction in chronic smokersQ71884045
Vitamin E supplementation and cardiovascular events in high-risk patientsQ73365511
Randomized, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate toleranceQ73841638
Dietary antioxidants inhibit development of fatty streak lesions in the LDL receptor-deficient mouseQ77319015
Human biliverdin reductase, a previously unknown activator of protein kinase C betaIIQ79571356
Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stressQ79667081
Inhibition of heme oxygenase-1 protects against tissue injury in carbon tetrachloride exposed liversQ79716212
Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling/dysfunction and survival after myocardial infarctionQ79856648
Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitratesQ80412476
Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiencyQ83314291
Association of a BLVRA common polymorphism with essential hypertension and blood pressure in KazaksQ84487352
The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters β-adrenergic receptor ligand-mediated cardiac dysfunctionQ34421837
Biliverdin reductase A in the prevention of cellular senescence against oxidative stressQ34587100
Vitamin supplement use in a low-risk population of US male physicians and subsequent cardiovascular mortalityQ34714377
Pharmacological and clinical aspects of heme oxygenaseQ34759206
Pathophysiology, diagnosis and prognostic implications of endothelial dysfunctionQ34766788
Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1.Q34829361
A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomenaQ34989686
Biliverdin Rescues the HO-2 Null Mouse Phenotype of Unresolved Chronic Inflammation Following Corneal Epithelial InjuryQ35027550
Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapyQ35227188
Redox regulation of vascular prostanoid synthesis by the nitric oxide-superoxide system.Q36253862
The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazineQ36287360
Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.Q36525653
Redox signaling: bioinorganic chemistry at its best.Q36649181
The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases.Q36716912
Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathwaysQ36962128
Dietary supplement with vitamin C prevents nitrate toleranceQ37386992
Inhibition of biliverdin reductase increases ANG II-dependent superoxide levels in cultured renal tubular epithelial cellsQ37422104
Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunctionQ37608376
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen speciesQ37685389
Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settingsQ37779560
Is bilirubin good for you?Q37941035
Free radical biology of the cardiovascular systemQ37997802
Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells.Q38329866
Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubinQ39709235
Effects of pentaerythritol tetranitrate on endothelial function in coronary artery disease: results of the PENTA studyQ39910169
Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancyQ39950254
Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductaseQ40105288
Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathwayQ41032847
Cycling the wagons for biliverdin reductaseQ42685813
Overexpression of biliverdin reductase enhances resistance to chemotherapeuticsQ42819675
The biliverdin-bilirubin antioxidant cycle of cellular protection: Missing a wheel?Q43024048
Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo studyQ43723169
Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo studyQ43727866
Dietary vitamin C supplementation decreases blood pressure in DOCA-salt hypertensive male Sprague-Dawley rats and this is associated with increased liver oxidative stressQ44140097
Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbitsQ44182297
Interaction of bilirubin and biliverdin with reactive nitrogen speciesQ44445583
Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteersQ44454399
Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate toleranceQ44671850
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertensionQ44810023
P407language of work or nameEnglishQ1860
P304page(s)30
P577publication date2012-03-16
P1433published inFrontiers in PharmacologyQ2681208
P1476titleDirect Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase?
P478volume3

Reverse relations

cites work (P2860)
Q92613362A five-year follow-up study of antioxidants, oxidative stress and polyunsaturated fatty acids in schizophrenia
Q34916684A product of heme catabolism modulates bacterial function and survival
Q92940082Acute bilirubin ditaurate exposure attenuates ex vivo platelet reactive oxygen species production, granule exocytosis and activation
Q48100837Anaerobic Heme Degradation: ChuY Is an Anaerobilin Reductase That Exhibits Kinetic Cooperativity.
Q36533800Antioxidants condition pleiotropic vascular responses to exogenous H(2)O(2): role of modulation of vascular TP receptors and the heme oxygenase system
Q50223910Bilirubin Levels are Associated With Contrast-Induced Nephropathy in Peripheral Artery Disease.
Q52679682Biliverdin Reductase and Bilirubin in Hepatic Disease.
Q27728148Blue protein with red fluorescence
Q38196955CO and CO-releasing molecules (CO-RMs) in acute gastrointestinal inflammation
Q89597208Cannabidiol Protects Dopaminergic Neurons in Mesencephalic Cultures against the Complex I Inhibitor Rotenone Via Modulation of Heme Oxygenase Activity and Bilirubin
Q90459594Carbon Monoxide Partially Mediates Protective Effect of Resveratrol Against UVB-Induced Oxidative Stress in Human Keratinocytes
Q26765308Cytoprotective role of heme oxygenase-1 in liver ischemia reperfusion injury
Q45373542Difference in cerebral blood flow velocity in neonates with and without hyperbilirubinemia
Q88952378Early Feed Restriction Programs Metabolic Disorders in Fattening Merino Lambs
Q38434603Effect of switch to the highest dose of rosuvastatin versus add-on-statin fenofibrate versus add-on-statin nicotinic acid/laropiprant on oxidative stress markers in patients with mixed dyslipidemia.
Q34718303Effects of biliverdin administration on acute lung injury induced by hemorrhagic shock and resuscitation in rats
Q89820050Heme Oxygenase Dependent Bilirubin Generation in Vascular Cells: A Role in Preventing Endothelial Dysfunction in Local Tissue Microenvironment?
Q36950942Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review
Q99625046Heme oxygenase-1 inhibition promotes IFNγ- and NOS2-mediated control of Mycobacterium tuberculosis infection
Q40547202Higher direct bilirubin levels during mid-pregnancy are associated with lower risk of gestational diabetes mellitus
Q36034631Immunometabolic Status during the Peripartum Period Is Enhanced with Supplemental Zn, Mn, and Cu from Amino Acid Complexes and Co from Co Glucoheptonate
Q35078156Induction of heme oxygenase-1 contributes to survival of Mycobacterium abscessus in human macrophages-like THP-1 cells
Q34014666Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells
Q48324216Lipid peroxidation, DNA damage and total antioxidant status in neonatal hyperbilirubinemia
Q55381728Multiple origins of green blood in New Guinea lizards.
Q38725099Pinocembrin Attenuates Mitochondrial Dysfunction in Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal: Role for the Erk1/2-Nrf2 Signaling Pathway
Q46433045Pinocembrin Suppresses H2O2-Induced Mitochondrial Dysfunction by a Mechanism Dependent on the Nrf2/HO-1 Axis in SH-SY5Y Cells
Q38673940Quercetin and tin protoporphyrin attenuate hepatic ischemia reperfusion injury: role of HO-1.
Q60934542Regenerative Effects of Heme Oxygenase Metabolites on Neuroinflammatory Diseases
Q37099894Regular cigarette smoking influences the transsulfuration pathway, endothelial function, and inflammation biomarkers in a sex-gender specific manner in healthy young humans
Q27715540Rv2074 is a novel F420 H2 -dependent biliverdin reductase in Mycobacterium tuberculosis
Q88209561S,N-doped carbon dots as a fluorescent probe for bilirubin
Q92709736Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors
Q39314184Serum total bilirubin levels and disease severity in patients with stable coronary artery disease
Q30408737Shrinkage of prostate and improved quality of life: Management of BPH patients with croton membranaceus ethanolic root extract
Q37653688Signaling function of heme oxygenase proteins.
Q28073380Sun Exposure and Its Effects on Human Health: Mechanisms through Which Sun Exposure Could Reduce the Risk of Developing Obesity and Cardiometabolic Dysfunction
Q48006787Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia
Q33737263The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer's Disease
Q90045468The complexity of porphyrin-like pigments in a marine annelid sheds new light on haem metabolism in aquatic invertebrates
Q26864505The haptoglobin-CD163-heme oxygenase-1 pathway for hemoglobin scavenging
Q34295822The heme oxygenases: important regulators of pregnancy and preeclampsia
Q46510112The influence of changes in expression of redox-sensitive genes on the development of retinopathy in rats
Q42235267The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity, and cytoprotection
Q38115527Therapeutic approaches to limit hemolysis-driven endothelial dysfunction: scavenging free heme to preserve vasculature homeostasis

Search more.