Effects of trauma-hemorrhage and IL-6 deficiency on splenic immune function in a murine trauma model

scientific article published on 9 February 2012

Effects of trauma-hemorrhage and IL-6 deficiency on splenic immune function in a murine trauma model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2012/186709
P932PMC publication ID3306962
P698PubMed publication ID22496597
P5875ResearchGate publication ID223977858

P2093author name stringC Krettek
C Neunaber
C Zeckey
H Andruszkow
P Mommsen
T Barkhausen
P2860cites workFemale sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsisQ28344087
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Suppression of activation and costimulatory signaling in splenic CD4+ T cells after trauma-hemorrhage reduces T-cell function: a mechanism of post-traumatic immune suppressionQ37362072
IL-6 predicts organ dysfunction and mortality in patients with multiple injuries.Q37389649
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NS-398 treatment after trauma modifies NF-kappaB activation and improves survivalQ43614364
Divergent immune responses in male and female mice after trauma-hemorrhage: dimorphic alterations in T lymphocyte steroidogenic enzyme activitiesQ43679968
Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout miceQ43708515
17 beta-Estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhageQ43730247
Estrogen pretreatment protects males against hypoxia-induced immune depressionQ43952347
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Absence of endogenous interleukin-10 enhances the evolution of acute lung injury.Q44136693
IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in miceQ44457678
Gender affects macrophage cytokine and prostaglandin E2 production and PGE2 receptor expression after traumaQ45136026
Neuroendocrine responses mediate macrophage function after traumaQ45137417
Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage?Q47442925
Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage.Q47717957
Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in miceQ48685503
Trauma-induced alterations in macrophage functionQ74147712
Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhageQ78009036
Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhageQ79194833
Depressed T cell-derived IFN-gamma following trauma-hemorrhage: a potential mechanism for diminished APC responsesQ80010075
THE PPARgamma ligand 15d-PGJ2 modulates macrophage activation after injury in a murine trauma modelQ80352605
Impact of the method of initial stabilization for femoral shaft fractures in patients with multiple injuries at risk for complications (borderline patients)Q80838811
Transgenic prolactin-/- mice: effect of trauma-hemorrhage on splenocyte functionsQ81152253
Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsisQ83885619
Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation.Q50971770
Dominance of T-helper 2-type cytokines after severe injury.Q51556610
Influence of sex and age on mods and cytokines after multiple injuries.Q51770348
Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage.Q51771416
Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females.Q51791949
Impaired immune and acute-phase responses in interleukin-6-deficient mice.Q52514391
Depressed antigen presentation function and membrane interleukin-1 activity of peritoneal macrophages after laparotomy.Q54279027
Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of traumaQ58421547
Prolonged Immunodepression after Trauma and Hemorrhagic ShockQ60156892
TRAUMA-HEMORRHAGE CAUSES PROLONGED DEPRESSION IN CELLULAR IMMUNITYQ60156976
Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity. Involvement of cell-associated tumor necrosis factor and reactive nitrogenQ67783108
Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsisQ69713427
The aromatase inhibitor, 4-hydroxyandrostenedione, restores immune responses following trauma-hemorrhage in males and decreases mortality from subsequent sepsisQ73070001
The effect of burn injury on suppressors of cytokine signallingQ73070024
Immunoprotection in proestrus females following trauma-hemorrhage: the pivotal role of estrogen receptorsQ73506453
Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shockQ73512893
Candida infection following severe trauma exacerbates Th2 cytokines and increases mortalityQ73513097
Acute alcohol intoxication and gadolinium chloride attenuate endotoxin-induced release of CC chemokines in the ratQ73555050
Insight into the mechanism by which metoclopramide improves immune functions after trauma-hemorrhageQ74013575
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectimmune functionQ124683452
P304page(s)186709
P577publication date2012-02-09
P1433published inMediators of InflammationQ2144494
P1476titleEffects of trauma-hemorrhage and IL-6 deficiency on splenic immune function in a murine trauma model
P478volume2012

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cites work (P2860)
Q47791665Mitochondrial dysfunction in rat splenocytes following hemorrhagic shock
Q57023031Splenectomy modulates early immuno-inflammatory responses to trauma-hemorrhage and protects mice against secondary sepsis

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