Recombinant adeno-associated virus vectors for gene therapy

scientific article published in July 2004

Recombinant adeno-associated virus vectors for gene therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1517/14712598.4.7.1093
P698PubMed publication ID15268676

P2093author name stringTerence R Flotte
Thomas J Conlon
P2860cites workMutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropismQ24515072
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In vitro selection of viral vectors with modified tropism: the adeno-associated virus displayQ33187644
Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypesQ33793801
Impaired intracellular trafficking of adeno-associated virus type 2 vectors limits efficient transduction of murine fibroblastsQ33796712
Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cellsQ34090326
The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivityQ34124491
A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19.Q34156171
Rescue and replication signals of the adeno-associated virus 2 genomeQ34301032
Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.Q34433170
AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infectionQ34486863
Production of clinical-grade recombinant adeno-associated virus vectorsQ35012878
Adeno-associated viruses undergo substantial evolution in primates during natural infectionsQ35022838
Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscleQ35054512
Receptor targeting of adeno-associated virus vectorsQ35165723
From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapyQ35180997
Trans-splicing vectors expand the utility of adeno-associated virus for gene therapyQ35799349
Site-specific integration by adeno-associated virus is directed by a cellular DNA sequenceQ35829692
Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic proteinQ35943644
Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virusQ36159178
Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristicsQ36460379
DNA-dependent PK inhibits adeno-associated virus DNA integrationQ36604872
Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectorsQ36734619
Humoral immunity to adeno-associated virus type 2 vectors following administration to murine and nonhuman primate muscleQ39589663
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectorsQ39589898
Enhancement of muscle gene delivery with pseudotyped adeno-associated virus type 5 correlates with myoblast differentiation.Q39606539
Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors.Q39682659
Infection of purified nuclei by adeno-associated virus 2.Q40775943
Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'gamma)2 antibodyQ40969562
Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integrationQ41431346
Gene expression from adeno-associated virus vectors in airway epithelial cellsQ41606833
Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.Q41722852
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectorsQ43716886
Intramuscular administration of recombinant adeno-associated virus 2 alpha-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic aspectsQ44136395
Efficient trans-splicing in the retina expands the utility of adeno-associated virus as a vector for gene therapy.Q44305893
Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brainQ44686125
In vivo trans-splicing of 5' and 3' segments of pre-mRNA directed by corresponding DNA sequences delivered by gene transferQ44686129
Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD miceQ44719693
Transgene expression after rep-mediated site-specific integration into chromosome 19.Q45019591
Genetic modifications of the adeno-associated virus type 2 capsid reduce the affinity and the neutralizing effects of human serum antibodiesQ45709087
Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivoQ45709105
Structure determination of adeno-associated virus 2: three complete virus particles per asymmetric unitQ45723313
Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectorsQ45735547
Overcoming adeno-associated virus vector size limitation through viral DNA heterodimerizationQ45742577
Quantitative analysis of the packaging capacity of recombinant adeno-associated virusQ45766162
Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicingQ45863479
Targeted transgene integration into transgenic mouse fibroblasts carrying the full-length human AAVS1 locus mediated by HSV/AAV rep(+) hybrid amplicon vector.Q45864772
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectgene therapyQ213901
vector-borne diseaseQ2083837
P304page(s)1093-1101
P577publication date2004-07-01
P1433published inExpert Opinion on Biological TherapyQ5421201
P1476titleRecombinant adeno-associated virus vectors for gene therapy
P478volume4

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