Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15.

scientific article published on 29 June 2015

Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2015/326359
P932PMC publication ID4499629
P698PubMed publication ID26221611
P5875ResearchGate publication ID280586998

P50authorAlessandra PudduQ59194506
Giorgio Luciano VivianiQ59194510
Fabrizio MontecuccoQ41112895
P2093author name stringRoberta Sanguineti
P2860cites workThe pathogenesis of NIDDM involves a defective expression of the GIP receptorQ58449027
Incretin effect due to increased secretion and decreased clearance of insulin in normal humansQ68149026
Reduced incretin effect in type 2 (non-insulin-dependent) diabetesQ68865252
Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cellsQ70869265
Plasma levels of pentosidine in diabetic patients: an advanced glycation end productQ77197610
A sensitive and specific ELISA for plasma pentosidineQ77292141
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetesQ79953668
Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker ratQ81096377
The role of "metabolic memory" in the natural history of diabetes mellitusQ84583263
Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responsesQ93538767
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetesQ28273497
A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cellsQ28567736
Chronic desensitization of the glucose-dependent insulinotropic polypeptide receptor in diabetic ratsQ28570330
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transductionQ29618388
Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?Q33803409
Advanced glycation end-products: a reviewQ34196489
Glucagon-like peptide 1(GLP-1) in biology and pathologyQ34401791
Gastric inhibitory polypeptide: the neglected incretin revisitedQ34758871
The role of incretins in glucose homeostasis and diabetes treatmentQ34901533
Advanced glycation end-products and the progress of diabetic vascular complications.Q35717287
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitusQ35824086
Clinical endocrinology and metabolism. Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptideQ35943434
Clinical review 2: The "metabolic memory": is more than just tight glucose control necessary to prevent diabetic complications?Q37344529
Glucagon-like peptide-1 secreting cell function as well as production of inflammatory reactive oxygen species is differently regulated by glycated serum and high levels of glucoseQ37598515
Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memoryQ37667703
The incretin concept todayQ39227026
Glucagon-like peptide-1 counteracts the detrimental effects of Advanced Glycation End-Products in the pancreatic beta cell line HIT-T 15.Q39685254
Advanced glycation end-products affect transcription factors regulating insulin gene expressionQ39720923
New developments in the incretin conceptQ39832287
Glycated fetal calf serum affects the viability of an insulin-secreting cell line in vitro.Q40025987
Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and dowQ40437409
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cellsQ40710884
Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signalingQ40784305
Glucose-dependent insulinotropic polypeptide stimulates insulin secretion via increased cyclic AMP and [Ca2+]1 and a wortmannin-sensitive signalling pathwayQ41184207
The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjectsQ42436041
Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.Q42503767
Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrationsQ42511153
Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetesQ43778779
Pentosidine as a biomarker for microvascular complications in type 2 diabetic patientsQ46395512
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)326359
P577publication date2015-06-29
P1433published inJournal of Diabetes ResearchQ26841822
P1476titleEffects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15.
P478volume2015

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