Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia (scientific article published on 21 February 2012)

Hemophilia as a defect of the tissue factor pathway of blood coagulation: effect of factors VIII and IX on factor X activation in a continuous-flow reactor

Q33822980

Factor VII deficiency rescues the intrauterine lethality in mice associated with a tissue factor pathway inhibitor deficit

Q33843110

Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulation inhibitor: evidence that endothelium is the principal site of its synthesis

Q33895278

AN ENZYME CASCADE IN THE BLOOD CLOTTING MECHANISM, AND ITS FUNCTION AS A BIOCHEMICAL AMPLIFIER.

Q34257237

WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING.

Q34257361

Active tissue factor pathway inhibitor is expressed on the surface of coated platelets

Q35642785

The role of tissue factor pathway inhibitor in a revised coagulation cascade

Q36370143

Combined tissue factor pathway inhibitor and thrombomodulin deficiency produces an augmented hypercoagulable state with tissue-specific fibrin deposition

Q36823197

Temporal expression of alternatively spliced forms of tissue factor pathway inhibitor in mice.

Q37418452

Alternatively spliced isoforms of tissue factor pathway inhibitor

Q37696775

Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A.

Q40575096

Murine hematopoietic cell tissue factor pathway inhibitor limits thrombus growth

Q42700253

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.

Q42950062

Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A

Q45868121

Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor

Q45868138

Activated factor X and thrombin formation triggered by tissue factor on endothelial cell matrix in a flow model: effect of the tissue factor pathway inhibitor.

Q45871920

Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A.

Q45872405

Blocking of tissue factor pathway inhibitor (TFPI) shortens the bleeding time in rabbits with antibody induced haemophilia A.

Q45876184

Effect of lipoprotein-associated coagulation inhibitor (LACI) on thromboplastin-induced coagulation of normal and hemophiliac plasmas

Q45881092

Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice.

Q52526571

Thrombin Induces the Redistribution and Acute Release of Tissue Factor Pathway Inhibitor From Specific Granules Within Human Endothelial Cells in Culture

Q53722832

Regulation of monocyte procoagulant activity in acute myocardial infarction: role of tissue factor and tissue factor pathway inhibitor-1

Q57374924

Inhibition of extrinsic pathway inhibitor shortens the coagulation time of normal plasma and of hemophilia plasma

Q67866847

Platelets secrete a coagulation inhibitor functionally and antigenically similar to the lipoprotein associated coagulation inhibitor

Q70412786

Acute release of tissue factor pathway inhibitor after in vivo thrombin generation in baboons

Q73307852

Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor

Q74192371

Expression of tissue factor pathway inhibitor in vascular smooth muscle cells and its regulation by growth factors

Q77677300

Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden

Q78057268

A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice

Q81144269

P4510

describes a project that uses

ImageJ

Q1659584

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

hemophilia

Q134003

P304

page(s)

3927-3931

P577

publication date

2012-02-21

P1433

published in

Proceedings of the National Academy of Sciences of the United States of America

Q1146531

P1476

title

Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia

P478

volume

109

Reverse relations

cites work (P2860)

Q92020423	A Molecular Revolution in the Treatment of Hemophilia
Q35784515	A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development
Q35126274	Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor
Q57289034	Anti-tissue factor pathway inhibitor (TFPI) therapy: a novel approach to the treatment of haemophilia
Q64113389	Assessing Blood Clotting and Coagulation Factors in Mice
Q33585249	Biology of tissue factor pathway inhibitor.
Q34657739	Breast cancer phenotypes regulated by tissue factor-factor VII pathway: Possible therapeutic targets
Q37268966	Cellular expression and biological activities of alternatively spliced forms of tissue factor pathway inhibitor
Q36852177	Comparison of the inhibitory activities of human tissue factor pathway inhibitor (TFPI)α and TFPIβ
Q55447752	Correlates of plasma and platelet tissue factor pathway inhibitor, factor V, and Protein S.
Q92218948	Defective fibrin deposition and thrombus stability in Bambi-/- mice are mediated by elevated anticoagulant function
Q39952594	Development of a tail vein transection bleeding model in fully anaesthetized haemophilia A mice - characterization of two novel FVIII molecules.
Q55123953	Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia.
Q45863501	Engineering a new generation of hemostatic agents: highlights of the Scientific Session on Hemostasis at the 2013 meeting of the American Society of Hematology
Q38114123	Hemophilia A and hemophilia B: focus on arthropathy and variables affecting bleeding severity and prophylaxis
Q55346403	Inhibition of Tissue Factor Pathway Inhibitor (TFPI) as a Treatment for Haemophilia: Rationale with Focus on Concizumab.
Q61796552	Maintaining extraembryonic expression allows generation of mice with severe tissue factor pathway inhibitor deficiency
Q90683939	Measurement of plasma and platelet tissue factor pathway inhibitor, factor V and Protein S in people with haemophilia
Q26865048	New insights into the biology of tissue factor pathway inhibitor
Q38604626	New products for the treatment of haemophilia
Q38293116	Novel therapeutic approaches for haemophilia
Q36269547	Platelet full length TFPI-α in healthy volunteers is not affected by sex or hormonal use.
Q36169665	Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI.
Q37007335	Platelets: Context-Dependent Vascular Protectors or Mediators of Disease
Q33648222	Protein S is a cofactor for platelet and endothelial tissue factor pathway inhibitor-α but not for cell surface-associated tissue factor pathway inhibitor
Q47900623	Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex
Q93192263	Serum lipoprotein(a) and risk of hemorrhagic stroke among incident peritoneal dialysis patients: a large study from a single center in China
Q93206771	Suppressing protein Z-dependent inhibition of factor Xa improves coagulation in hemophilia A
Q37108074	Targeting TFPI for hemophilia treatment
Q47215919	Targeting anticoagulant protein S to improve hemostasis in hemophilia.
Q55211396	The Potential Close Future of Hemophilia Treatment - Gene Therapy, TFPI Inhibition, Antithrombin Silencing, and Mimicking Factor VIII with an Engineered Antibody.
Q38840382	The hemostatic role of factor XI.
Q36403196	Tissue Factor Pathway Inhibitor: Multiple Anticoagulant Activities for a Single Protein
Q37276726	Tissue factor pathway inhibitor-alpha inhibits prothrombinase during the initiation of blood coagulation
Q33706688	Translation of human tissue factor pathway inhibitor-β mRNA is controlled by alternative splicing within the 5' untranslated region.

P819	ADS bibcode	2012PNAS..109.3927M
P356	DOI	10.1073/PNAS.1119858109
P932	PMC publication ID	3309760
P698	PubMed publication ID	22355108
P5875	ResearchGate publication ID	221851914