Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa

scientific article published on 22 December 2005

Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2005-11-4374
P932PMC publication ID1895757
P698PubMed publication ID16373659
P5875ResearchGate publication ID7396917

P50authorMarcin MoniuszkoQ30902433
Jay A BerzofskyQ61160082
Mark G. LewisQ66732036
P2093author name stringWarren Strober
Vladimir A Kuznetsov
Genoveffa Franchini
Igor M Belyakov
John D Clements
Phillip D Markham
Ranajit Pal
Brian Kelsall
Dennis Klinman
Michael Lemon
P2860cites workCD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tractQ22242981
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Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infectionQ29619099
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Induction of a mucosal cytotoxic T-lymphocyte response by intrarectal immunization with a replication-deficient recombinant vaccinia virus expressing human immunodeficiency virus 89.6 envelope protein.Q33784928
Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuationQ33814150
CD8(+) lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: implications for vaccine design and testingQ33835440
A push-pull approach to maximize vaccine efficacy: abrogating suppression with an IL-13 inhibitor while augmenting help with granulocyte/macrophage colony-stimulating factor and CD40LQ34191248
Construction of peptides encompassing multideterminant clusters of human immunodeficiency virus envelope to induce in vitro T cell responses in mice and humans of multiple MHC typesQ34197974
ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiencyQ34326613
Both mucosal and systemic routes of immunization with the live, attenuated NYVAC/simian immunodeficiency virus SIV(gpe) recombinant vaccine result in gag-specific CD8(+) T-cell responses in mucosal tissues of macaques.Q34355037
Strategies for designing and optimizing new generation vaccinesQ34572198
The quest for an AIDS vaccine: is the CD8+ T-cell approach feasible?Q34632089
Cytokine, Chemokine, and Costimulatory Molecule Modulation to Enhance Efficacy of HIV VaccinesQ35109075
Mucosal vaccination overcomes the barrier to recombinant vaccinia immunization caused by preexisting poxvirus immunityQ35130248
Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine virusesQ35234767
Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccinesQ35696885
Molecular mechanisms and biological significance of CTL avidityQ35716722
Present status of human HIV vaccine developmentQ35744225
Mucosal AIDS vaccines: current status and future directionsQ35851782
Chimeric simian/human immunodeficiency virus that causes progressive loss of CD4+ T cells and AIDS in pig-tailed macaquesQ35860556
Progress on new vaccine strategies against chronic viral infectionsQ35864857
Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challengeQ35884740
Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaquesQ36366154
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.Q36368095
Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complexQ36400759
Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptidesQ36400848
Antiviral cytotoxic T lymphocytes in vaginal mucosa of simian immunodeficiency virus-infected rhesus macaquesQ36546178
Transcutaneous immunization induces mucosal CTLs and protective immunity by migration of primed skin dendritic cellsQ37221714
The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12.Q37388157
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.Q37589836
Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.Q37629901
High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL.Q40830770
NYVAC: a highly attenuated strain of vaccinia virusQ41626050
Selective induction of high avidity CTL by altering the balance of signals from APC.Q42804988
Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific CTL.Q42833971
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.Q44022556
Activating CTL precursors to reveal CTL function without skewing the repertoire by in vitro expansionQ45124959
Assessment of the relative therapeutic effects of vaccines on virus load and immune responses in small groups at several time points: efficacy of mucosal and subcutaneous polypeptide vaccines in rhesus macaques exposed to SHIV.Q45543090
Containment of simian immunodeficiency virus infection in vaccinated macaques: correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responsesQ45730388
Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infectionQ45732713
Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunityQ45734062
Quantitative evaluation of simian immunodeficiency virus infection using NASBA technologyQ45743923
Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from simian immunodeficiency virus.Q45755361
Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regimeQ56774528
Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4+ T CellsQ57075707
Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaquesQ57089572
HIV-1 expression in chimpanzees can be activated by CD8+ cell depletion or CMV infectionQ67507345
Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytesQ73224720
A high frequency of Mamu-A*01 in the rhesus macaque detected by polymerase chain reaction with sequence-specific primers and direct sequencingQ74150972
CpG oligodeoxynucleotides as vaccine adjuvants in primatesQ77584362
Selective induction of protective MHC class I-restricted CTL in the intestinal lamina propria of rhesus monkeys by transient SIV infection of the colonic mucosaQ77787637
Protection by SIV VLP DNA prime/protein boost following mucosal SIV challenge is markedly enhanced by IL-12/GM-CSF co-administrationQ78402667
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectvaccineQ134808
P304page(s)3258-3264
P577publication date2005-12-22
P1433published inBloodQ885070
P1476titleImpact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa
P478volume107

Reverse relations

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