The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages

scientific article published on 18 April 2006

The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1182/BLOOD-2005-12-012815
P932PMC publication ID1895866
P698PubMed publication ID16621960
P5875ResearchGate publication ID7158284

P2093author name stringBrian Tomkowicz
Ronald G Collman
Chuhee Lee
Ricky Cheung
Andrzej Ptasznik
Vipa Ravyn
P2860cites workSHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathwaysQ24290736
Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cellsQ24291028
Src-family kinases in B-cell development and signalingQ24307580
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activationQ24312845
G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling ComplexesQ24324803
Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathwayQ24523390
HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replicationQ24534883
Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophagesQ24541375
HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulationQ24676438
Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and SykQ28140552
Human immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein kinases in human neuronsQ28256919
gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylationQ28286708
Lyn tyrosine kinase: accentuating the positive and the negativeQ28303638
Src family kinases, key regulators of signal transductionQ30434839
Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strainsQ33647409
Preferential use of CXCR4 by R5X4 human immunodeficiency virus type 1 isolates for infection of primary lymphocytesQ33716586
CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopesQ33807693
Pathways to neuronal injury and apoptosis in HIV-associated dementia.Q34223078
G-protein-coupled receptors and signaling networks: emerging paradigms.Q34296103
HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.Q34440467
Novel regulation and function of Src tyrosine kinase.Q34607252
Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection.Q35764050
gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5Q36165694
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophagesQ36340560
Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cellsQ36371049
Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5.Q36380882
Human immunodeficiency virus type 1 gp120 induces abnormal maturation and functional alterations of dendritic cells: a novel mechanism for AIDS pathogenesis.Q37492783
HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway.Q39254646
Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutationQ39382962
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptorQ39585768
Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenograftsQ40590762
HIV-1 gp120 stimulates the production of beta-chemokines in human peripheral blood monocytes through a CD4-independent mechanismQ40811270
Lack of p56lck expression correlates with CD4 endocytosis in primary lymphoid and myeloid cellsQ40990044
Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinasesQ41175767
Chemokine receptors: gateways to inflammation and infectionQ41193992
Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptorsQ41206249
Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementiaQ42474669
HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signalingQ43792124
Not so strange bedfellows: G-protein-coupled receptors and Src family kinasesQ45111099
Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokinesQ46722581
Macrophage inflammatory protein 1 modulates macrophage functionQ68107144
Purification of human monocytes: isolation and collection of large numbers of peripheral blood monocytesQ71366109
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinaseQ73541784
Early activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressinQ95815747
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1145-1150
P577publication date2006-04-18
P1433published inBloodQ885070
P1476titleThe Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1 gp120 in human macrophages
P478volume108

Reverse relations

cites work (P2860)
Q37362947An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages
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Q39627809Chemoattractant-Induced Signaling via the Ras–ERK and PI3K–Akt Networks, along with Leukotriene C4 Release, Is Dependent on the Tyrosine Kinase Lyn in IL-5– and IL-3–Primed Human Blood Eosinophils
Q37418469Circulating monocytes in HIV-1-infected viremic subjects exhibit an antiapoptosis gene signature and virus- and host-mediated apoptosis resistance
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Q39960487Dual acylation and lipid raft association of Src-family protein tyrosine kinases are required for SDF-1/CXCL12-mediated chemotaxis in the Jurkat human T cell lymphoma cell line
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Q37221535Essential Role of Lyn in Fibrosis
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Q33631051Wu-Tou Decoction in Rheumatoid Arthritis: Integrating Network Pharmacology and In Vivo Pharmacological Evaluation

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