Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes

scientific article published on 23 November 2015

Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1043001Y
P356DOI10.1371/JOURNAL.PONE.0143001
P932PMC publication ID4658142
P698PubMed publication ID26600079
P5875ResearchGate publication ID284713140

P50authorThomas WaldmannQ21042387
Jay A BerzofskyQ61160082
P2093author name stringZheng Xia
Yichuan Wang
Noriko Sato
Huifeng Yu
Yongjun Sui
Blake Frey
P2860cites workCloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptorQ24313035
IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesisQ24604346
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cellsQ24621753
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homingQ24646057
Essential role for CD103 in the T cell-mediated regulation of experimental colitisQ24646106
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestineQ24648636
Dendritic cell subsets in the intestinal lamina propria: ontogeny and functionQ26997819
IL-17 and Th17 CellsQ27860566
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
IL-15Ralpha recycles and presents IL-15 In trans to neighboring cellsQ28214975
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient miceQ28594052
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismQ29614266
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generationQ29614840
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidQ29615586
IL-17 family cytokines and the expanding diversity of effector T cell lineagesQ29619361
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidQ29619479
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteriaQ29619620
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophagesQ29620142
Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.Q33361113
Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiationQ33854794
Ontogenic, Phenotypic, and Functional Characterization of XCR1(+) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPαQ33958439
Focused specificity of intestinal TH17 cells towards commensal bacterial antigensQ34026652
Interleukin 15: biology and relevance to human diseaseQ34116304
Interleukin-2 and interleukin-15: immunotherapy for cancer.Q34568715
Mucosal dendritic cellsQ34611254
CCR2(+)CD103(-) intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cellsQ34734057
Distinct dendritic cell subsets differentially regulate the class of immune response in vivoQ34950113
Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cellsQ35087813
Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.Q35091226
IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic miceQ35296962
A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cellsQ35327308
Guardians of the Gut - Murine Intestinal Macrophages and Dendritic Cells.Q35672744
CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivoQ36367705
Interleukin 15 skews monocyte differentiation into dendritic cells with features of Langerhans cellsQ36369467
Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cellsQ36369770
Regulation of Th2 differentiation and Il4 locus accessibility.Q36427376
Th17: an effector CD4 T cell lineage with regulatory T cell tiesQ36510274
IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosisQ36516239
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine designQ36547207
The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytesQ36824184
Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo.Q36858877
IL-15 acts as a potent inducer of CD4(+)CD25(hi) cells expressing FOXP3.Q37198900
IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cellsQ37214198
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.Q37589836
Dendritic cells in intestinal homeostasis and disease.Q37591719
Deciphering the transcriptional network of the dendritic cell lineageQ37700905
Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men.Q38076962
Molecular pathways: interleukin-15 signaling in health and in cancerQ38204960
Intestinal macrophages and dendritic cells: what's the difference?Q38209216
Intestinal dendritic cellsQ38343914
Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillanceQ40515867
Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes.Q40684512
Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cellsQ40869698
IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levelsQ40976868
IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell developmentQ42932412
Intestinal CD103(-) dendritic cells migrate in lymph and prime effector T cells.Q43975582
Mucosal dendritic cells in immunity and inflammationQ45053078
Enhancement of protective humoral (Th2) and cell-mediated (Th1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte-macrophage colony-stimulating factor expression cassettesQ45752455
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.Q46564597
Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.Q50793292
Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo.Q50885261
IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation.Q51002504
Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.Q51991024
Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses.Q51991224
A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.Q53251529
Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Guérin infection via augmentation of NK and T cytotoxic 1 responses.Q54002862
High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4+ T cells for IFN-gamma but have differential effects on priming for IL-4Q71483420
Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogensQ74442122
Interleukin-15 differentially enhances the expression of interferon-gamma and interleukin-4 in activated human (CD4+) T lymphocytesQ77419183
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferationQ77658417
A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cellsQ80063671
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responsesQ81305086
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e0143001
P577publication date2015-11-23
P1433published inPLOS OneQ564954
P1476titleInterleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes
P478volume10

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cites work (P2860)
Q52544005CD4 effector T cell differentiation is controlled by IL-15 that is expressed and presented in trans.
Q92466463IL-15 negatively regulates curdlan-induced IL-23 production by human monocyte-derived dendritic cells and subsequent Th17 response
Q51021160Novel adjuvant for immunization against tuberculosis: DNA vaccine expressing Mycobacterium tuberculosis antigen 85A and interleukin-15 fusion product elicits strong immune responses in mice.

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