Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction

scientific article published on 25 November 2015

Role of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1043399R
P356DOI10.1371/JOURNAL.PONE.0143399
P932PMC publication ID4659624
P698PubMed publication ID26606751
P5875ResearchGate publication ID284718580

P50authorPatrick ScheererQ56721731
Klaus Peter HofmannQ104905205
Alexander S RoseQ42430143
Ulrich ZachariaeQ28355623
P2093author name stringHelmut Grubmüller
Peter W Hildebrand
P2860cites workThe hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiolsQ69909086
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsinQ71669056
Rhodopsin recognition by mutant G(s)alpha containing C-terminal residues of transducinQ73377976
Differential association modes of the thrombin receptor PAR1 with Galphai1, Galpha12, and beta-arrestin 1Q84090140
The role of ligands on the equilibria between functional states of a G protein-coupled receptorQ37149545
Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interfaceQ37250013
Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of GαiQ37289241
A G protein-coupled receptor at work: the rhodopsin model.Q37616633
Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP releaseQ37626332
Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperatureQ41775672
SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteinsQ42390741
SuperLooper--a prediction server for the modeling of loops in globular and membrane proteinsQ43103622
Position of transmembrane helix 6 determines receptor G protein coupling specificityQ45029861
Precision vs flexibility in GPCR signalingQ47944038
Characterization of rhodopsin mutants that bind transducin but fail to induce GTP nucleotide uptake. Classification of mutant pigments by fluorescence, nucleotide release, and flash-induced light-scattering assays.Q49164908
Rhodopsin mutants that bind but fail to activate transducinQ24300261
Activation and allosteric modulation of a muscarinic acetylcholine receptorQ24308061
Improved side-chain torsion potentials for the Amber ff99SB protein force fieldQ24616749
Crystal structure of the β2 adrenergic receptor-Gs protein complexQ24635327
Diversity and modularity of G protein-coupled receptor structuresQ26852976
Structure and orientation of a G protein fragment in the receptor bound state from residual dipolar couplingsQ27639607
Crystal structure of opsin in its G-protein-interacting conformationQ27652301
Crystal structure of metarhodopsin IIQ27666911
The structural basis of agonist-induced activation in constitutively active rhodopsinQ27667245
Stabilized G protein binding site in the structure of constitutively active metarhodopsin-IIQ27676468
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2Q27732195
Light-activated rhodopsin induces structural binding motif in G protein alpha subunitQ27749060
PRODRG: a tool for high-throughput crystallography of protein-ligand complexesQ27860633
GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular SimulationQ27860944
The Energy Landscapes and Motions of ProteinsQ29616408
Improved protein-ligand docking using GOLDQ29616787
g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbationQ30387289
Maximal rate and nucleotide dependence of rhodopsin-catalyzed transducin activation: initial rate analysis based on a double displacement mechanismQ31696241
Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complexQ33931230
Kinetic studies of protein-protein interactionsQ34525874
Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complexQ35062647
Conformational changes in the G protein Gs induced by the β2 adrenergic receptorQ36252945
Heterotrimeric G protein activation by G-protein-coupled receptorsQ37017125
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e0143399
P577publication date2015-11-25
P1433published inPLOS OneQ564954
P1476titleRole of Structural Dynamics at the Receptor G Protein Interface for Signal Transduction
P478volume10

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cites work (P2860)
Q27334008Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model
Q58718025Crystal structure of rhodopsin in complex with a mini-G sheds light on the principles of G protein selectivity
Q43075987Designing Safer Analgesics via μ-Opioid Receptor Pathways
Q57496184Exploring a new ligand binding site of G protein-coupled receptors
Q91959012Structural Insights into the Process of GPCR-G Protein Complex Formation
Q37200484The Molecular Mechanism of P2Y1 Receptor Activation

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