A critical role for the TAR element in promoting efficient human immunodeficiency virus type 1 reverse transcription

scientific article published in June 1996

A critical role for the TAR element in promoting efficient human immunodeficiency virus type 1 reverse transcription is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID190280
P698PubMed publication ID8648739

P2093author name stringHarrich D
Gaynor RB
Ulich C
P2860cites workViral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma VirusQ22122431
Retroviral Recombination and Reverse TranscriptionQ22242273
Cellular transcription factors involved in the regulation of HIV-1 gene expressionQ28272528
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structureQ28283258
HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequenceQ28646785
Selective extraction of polyoma DNA from infected mouse cell culturesQ29547500
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitorQ29547710
Characteristics of a human cell line transformed by DNA from human adenovirus type 5Q29547863
Control of RNA initiation and elongation at the HIV-1 promoterQ29620157
Interaction between retroviral U5 RNA and the T psi C loop of the tRNA(Trp) primer is required for efficient initiation of reverse transcriptionQ33933045
RNA-dependent DNA polymerase in virions of RNA tumour virusesQ34206460
The human immunodeficiency virus type 1 packaging signal and major splice donor region have a conserved stable secondary structureQ34434755
The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeatQ34564367
Specific binding of tryptophan transfer RNA to avian myeloblastosis virus RNA-dependent DNA polymerase (reverse transcriptase)Q35083339
Interactions with tRNALysinduce important structural changes in human immunodeficiency virus reverse transcriptaseQ45859998
Characterization of ribosomal frameshifting in HIV-1 gag-pol expressionQ46573916
RNA recognition by Tat-derived peptides: interaction in the major groove?Q50134622
A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activationQ68583028
Recombinant HIV-1 nucleocapsid protein accelerates HIV-1 reverse transcriptase catalyzed DNA strand transfer reactions and modulates RNase H activityQ71654297
Analysis of the Interactions of HIV1 Replication Primer tRNALys,3 with Nucleocapsid Protein and Reverse TranscriptaseQ72083397
An experiment-based model for the petrogenesis of high-alumina basaltsQ81196809
Retroviral Reverse Transcription and Integration: Progress and ProblemsQ35161317
RNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1.Q35837228
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replicationQ35838477
Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cellQ35840793
Retroviral reverse transcriptase: synthesis, structure, and functionQ36583854
A specific orientation of RNA secondary structures is required for initiation of reverse transcription.Q36626314
Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.Q36629265
Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replicationQ36635791
Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cellsQ36651389
Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycleQ36693174
Overlapping retrovirus U5 sequence elements are required for efficient integration and initiation of reverse transcriptionQ36701633
Construction and analysis of deletion mutations in the U5 region of Moloney murine leukemia virus: effects on RNA packaging and reverse transcription.Q36780266
A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphologyQ36784524
Deletions in the tRNA(Lys) primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse transcriptionQ36797561
Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virusQ36804927
Multiple transcriptional regulatory domains in the human immunodeficiency virus type 1 long terminal repeat are involved in basal and E1A/E1B-induced promoter activityQ36831514
A retroviral RNA secondary structure required for efficient initiation of reverse transcriptionQ36872904
Evolution of a disrupted TAR RNA hairpin structure in the HIV-1 virus.Q37633114
Human immunodeficiency viruses regulated by alternative trans-activators: genetic evidence for a novel non-transcriptional function of Tat in virion infectivity.Q37633631
Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombinationQ37701269
Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domainQ38290032
Human immunodeficiency virus type 1 TAR element revertant viruses define RNA structures required for efficient viral gene expression and replicationQ38293063
Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reactionQ38308091
Modified nucleotides of tRNA(3Lys) modulate primer/template loop-loop interaction in the initiation complex of HIV-1 reverse transcriptionQ38313621
Double-stranded strong-stop DNA and the second template switch in human immunodeficiency virus (HIV) DNA synthesisQ38319573
Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulationQ38345116
Peripheral blood mononuclear cells produce normal amounts of defective Vif- human immunodeficiency virus type 1 particles which are restricted for the preretrotranscription steps.Q39869534
Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursorsQ40039220
Differential growth kinetics are exhibited by human immunodeficiency virus type 1 TAR mutantsQ40041542
Efficient extension of a misaligned tRNA-primer during replication of the HIV-1 retrovirusQ40393707
Secondary structure of the HIV-2 leader RNA comprising the tRNA-primer binding siteQ40405750
HIV-1 tat protein stimulates transcription by binding to a U-rich bulge in the stem of the TAR RNA structureQ41234955
HIV-1 tat trans-activation requires the loop sequence within tar.Q44349676
Arginine-mediated RNA recognition: the arginine fork.Q44511258
Functional sites in the 5' region of human immunodeficiency virus type 1 RNA form defined structural domainsQ45774047
Interaction of primer tRNA(Lys3) with the p51 subunit of human immunodeficiency virus type 1 reverse transcriptase: a possible role in enzyme activationQ45789322
Molecular cloning and characterization of the HTLV-III virus associated with AIDSQ45807140
Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator proteinQ45830211
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)4017-4027
P577publication date1996-06-01
P1433published inJournal of VirologyQ1251128
P1476titleA critical role for the TAR element in promoting efficient human immunodeficiency virus type 1 reverse transcription
P478volume70

Reverse relations

cites work (P2860)
Q35879394A conserved hairpin motif in the R-U5 region of the human immunodeficiency virus type 1 RNA genome is essential for replication
Q34391750A nucleolar TAR decoy inhibitor of HIV-1 replication.
Q30303886An intact TAR element and cytoplasmic localization are necessary for efficient packaging of human immunodeficiency virus type 1 genomic RNA.
Q33850342An intact U5-leader stem is important for efficient replication of simian immunodeficiency virus.
Q38292600Destabilization of tRNA3(Lys) from the primer-binding site of HIV-1 genome by anti-A loop polyamide nucleotide analog
Q36230686Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA.
Q34362286Ebola virus VP30-mediated transcription is regulated by RNA secondary structure formation
Q24673792Efficient encapsidation of human immunodeficiency virus type 1 vectors and further characterization of cis elements required for encapsidation
Q33654155Functional domains of Tat required for efficient human immunodeficiency virus type 1 reverse transcription.
Q39548591Genetic dissociation of the encapsidation and reverse transcription functions in the 5' R region of human immunodeficiency virus type 1
Q35888060Human immunodeficiency virus type 1 nucleocapsid protein promotes efficient strand transfer and specific viral DNA synthesis by inhibiting TAR-dependent self-priming from minus-strand strong-stop DNA.
Q39877614Identification of a sequence within U5 required for human immunodeficiency virus type 1 to stably maintain a primer binding site complementary to tRNA(Met).
Q35890003Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.
Q28478188Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA
Q33799971Jembrana disease virus Tat can regulate human immunodeficiency virus (HIV) long terminal repeat-directed gene expression and can substitute for HIV Tat in viral replication
Q34366015Ligand-induced changes in 2-aminopurine fluorescence as a probe for small molecule binding to HIV-1 TAR RNA
Q39719048Optimal Tat-mediated activation of the HIV-1 LTR promoter requires a full-length TAR RNA hairpin
Q37473797Prospects for antisense peptide nucleic acid (PNA) therapies for HIV
Q28646669Sequences in the 5' and 3' R elements of human immunodeficiency virus type 1 critical for efficient reverse transcription
Q34363753Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription
Q56272235Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription
Q38347693Tat is required for efficient HIV-1 reverse transcription
Q39582195The 5' and 3' TAR elements of human immunodeficiency virus exert effects at several points in the virus life cycle
Q35870667The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin
Q33805882The human immunodeficiency virus type 1 TAR RNA upper stem-loop plays distinct roles in reverse transcription and RNA packaging
Q35890307Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.
Q37538534Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.

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