IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy

scientific article published on 25 March 2007

IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.NEULET.2007.01.086
P932PMC publication ID1903346
P698PubMed publication ID17418948
P5875ResearchGate publication ID6403668

P2093author name stringJohn M Petitto
Zhi Huang
Grace K Ha
P2860cites workThe roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both?Q28251025
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient miceQ28594052
Leukocyte traffic in the central nervous system: the participants and their rolesQ33636045
IL-15 and IL-15Ralpha in CD4+T cell immunityQ36146826
Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasisQ36427380
Migration of Hematogenous Cells Through the Blood-Brain Barrier and the Initiation of CNS InflammationQ36476893
IL-15 induces the expression of chemokines and their receptors in T lymphocytes.Q39349797
Interleukin-15, a T-cell growth factor, is expressed in human neural cell lines and tissuesQ41048144
Chemoattraction of human blood T lymphocytes by interleukin-15.Q41363083
Cloning the full-length IL-2/15 receptor-beta cDNA sequence from mouse brain: evidence of enrichment in hippocampal formation neuronsQ42642351
Reduced 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity response in IL-15 receptor alpha-deficient mice correlates with diminished CCL5/RANTES and CXCL10/IP-10 expressionQ45272499
Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration.Q47812473
CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transectionQ48213916
IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neuronsQ48415782
Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathwayQ48534206
Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activityQ48596563
IL-2/15 receptor-beta gene deletion alters neurobehavioral performanceQ48678295
Interleukin-15 gene expression in human astrocytes and microglia in culture.Q49010875
Kinetics of facial motoneuron loss following facial nerve transection in severe combined immunodeficient mice.Q52541193
T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression.Q54603693
Interleukin-15 (IL-15) induces IL-8 and monocyte chemotactic protein 1 production in human monocytesQ73774825
Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune responseQ77149801
Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesisQ77319192
IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferationQ77658417
Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) miceQ77789625
Endogenous T lymphocytes and microglial reactivity in the axotomized facial motor nucleus of mice: effect of genetic background and the RAG2 geneQ82076870
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmicrogliaQ1622829
gene traffickingQ97061854
P1104number of pages5
P304page(s)160-164
P577publication date2007-03-25
P1433published inNeuroscience LettersQ7002625
P1476titleIL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy
P478volume417

Reverse relations

cites work (P2860)
Q36889948An activation-induced IL-15 isoform is a natural antagonist for IL-15 function
Q39824117Blockade of IL-15 activity inhibits microglial activation through the NFkappaB, p38, and ERK1/2 pathways, reducing cytokine and chemokine release
Q30443708Brain interleukin-15 in neuroinflammation and behavior
Q33903242Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis
Q41680674Dissecting the effects of endogenous brain IL-2 and normal versus autoreactive T lymphocytes on microglial responsiveness and T cell trafficking in response to axonal injury
Q34172690Essential role of interleukin-15 receptor in normal anxiety behavior
Q42284660Influence of injury severity on the rate and magnitude of the T lymphocyte and neuronal response to facial nerve axotomy
Q51965788Interleukin 15 expression in the CNS: blockade of its activity prevents glial activation after an inflammatory injury.
Q35041585Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells
Q35147178Loss of CNS IL-2 gene expression modifies brain T lymphocyte trafficking: response of normal versus autoreactive Treg-deficient T cells
Q90564251Microglia Receptors in Animal Models of Traumatic Brain Injury
Q37660927Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis
Q41976595NFĸB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia
Q28486022Pharmacologic inhibition of CXCL10 in combination with anti-malarial therapy eliminates mortality associated with murine model of cerebral malaria
Q39620416Rapid endocytosis of interleukin-15 by cerebral endothelia
Q39806751Regulation of vacuolar H(+)-ATPase in microglia by RANKL.
Q35120051Serum interleukin (IL)-15 as a biomarker of Alzheimer's disease.
Q37880157The role of IL-15 in central nervous system disorders
Q34374669Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration.
Q33613350Use of laser microdissection in the investigation of facial motoneuron and neuropil molecular phenotypes after peripheral axotomy

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