Systemic inflammatory effects of traumatic brain injury, femur fracture, and shock: an experimental murine polytrauma model.

scientific article published on 4 March 2012

Systemic inflammatory effects of traumatic brain injury, femur fracture, and shock: an experimental murine polytrauma model. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1155/2012/136020
P932PMC publication ID3316998
P698PubMed publication ID22529516
P5875ResearchGate publication ID224825080

P50authorMartijn van GriensvenQ40978491
P2093author name stringC Zeckey
P Mommsen
M Maegele
C Probst
A Samii
M J Mirzayan
L Geerken
T Tegeder
P2860cites workRole of systemic inflammatory response syndrome and infection in the occurrence of early multiple organ dysfunction syndrome following severe trauma.Q51043190
Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury.Q52519393
Differential immunoresponses following experimental traumatic brain injury, bone fracture and "two-hit"-combined neurotrauma.Q53848001
Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxinQ60157042
Pattern of organ failure following severe traumaQ71141905
Pentoxifylline improves survival and reduces tumor necrosis factor, interleukin-6, and endothelin-1 in fulminant intra-abdominal sepsis in ratsQ72294716
The presence of tumour necrosis factor in CSF and plasma after severe head injuryQ72384761
Comparison of mortality, morbidity, and severity of 59,713 head injured patients with 114,447 patients with extracranial injuriesQ72897567
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Polymicrobial sepsis induces organ changes due to granulocyte adhesion in a murine two hit model of traumaQ78670042
Effects of changing strategies of fracture fixation on immunologic changes and systemic complications after multiple trauma: damage control orthopedic surgeryQ81396725
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injuryQ21245237
Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease StudyQ28239287
Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- miceQ28268523
Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cellsQ28572207
When should we operate on major fractures in patients with severe head injuries?Q34593934
Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?Q35589949
Animal models for trauma research: what are the options?Q37219483
IL-6 predicts organ dysfunction and mortality in patients with multiple injuries.Q37389649
Experimental trauma models: an updateQ37844440
Experimental closed head injury in rats: mechanical, pathophysiologic, and neurologic propertiesQ39628971
Multiple organ failure in trauma patientsQ39667457
Incidence and outcome of traumatic brain injury in an urban area in Western Europe over 10 yearsQ39808261
Late death after multiple severe trauma: when does it occur and what are the causes?Q39988459
Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokinesQ42504072
An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficitsQ42643769
Pentoxifylline improves survival following hemorrhagic shockQ46263263
Posttraumatic lymphocyte response: a comparison between peripheral blood T cells and tissue T cellsQ47783536
Secondary effects of femoral instrumentation on pulmonary physiology in a standardised sheep model: what is the effect of lung contusion and reaming?Q47835702
Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairmentQ48220313
Clinical and pathophysiological significance of severe neurotrauma in polytraumatized patientsQ48374820
Multiple organ failure still a major cause of morbidity but not mortality in blunt multiple traumaQ48713308
Elevation of tumor necrosis factor in head injuryQ48846961
Characterization of a new rat model of experimental combined neurotrauma.Q48925727
Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat.Q48987538
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjecttraumatic brain injuryQ1995526
bone fractureQ68833
inflammationQ101991
P304page(s)136020
P577publication date2012-03-04
P1433published inMediators of InflammationQ2144494
P1476titleSystemic inflammatory effects of traumatic brain injury, femur fracture, and shock: an experimental murine polytrauma model
P478volume2012

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cites work (P2860)
Q38730569Acute brain trauma, lung injury, and pneumonia: more than just altered mental status and decreased airway protection
Q41247526Bone Fracture Enhances Trauma Brain Injury
Q38948811Combined Neurotrauma Models: Experimental Models Combining Traumatic Brain Injury and Secondary Insults
Q36104936Hyperbaric Oxygen Reduces Production of Reactive Oxygen Species in Neutrophils from Polytraumatized Patients Yielding in the Inhibition of p38 MAP Kinase and Downstream Pathways.
Q56967866Impact of contusion injury on intramuscular emm1 group a streptococcus infection and lymphatic spread
Q49680446Interlocking Intramedullary Nailing Versus Locked Dual-Plating Fixation for Femoral Shaft Fractures in Patients with Multiple Injuries: A Retrospective Comparative Study
Q36666022Neuroanesthetic considerations for emergent extracranial surgeries: What to know?
Q28391048S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury
Q28392146S100B ranks as a new marker of multiple traumas in patients and may accelerate its development by regulating endothelial cell dysfunction
Q37350184Superimposed traumatic brain injury modulates vasomotor responses in third-order vessels after hemorrhagic shock
Q41874006Systemic inflammatory responses and lung injury following hip fracture surgery increases susceptibility to infection in aged rats
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Q26749547The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome
Q35925463Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitrauma.
Q38184971Traumatic brain injury using mouse models.

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