Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism

scientific article published on 21 January 2011

Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2010-08-303008
P932PMC publication ID3317770
P698PubMed publication ID21258007
P5875ResearchGate publication ID49777222

P50authorRobert S. NegrinQ110528996
P2093author name stringDennis B Leveson-Gower
Emanuela I Sega
Richard H Luong
Janelle A Olson
Jeanette Baker
Robert Zeiser
P2860cites workAnalysis of human V alpha 24+ CD4+ NKT cells activated by alpha-glycosylceramide-pulsed monocyte-derived dendritic cellsQ22253977
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.Q33528964
Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cellsQ33715925
Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayersQ34567309
Shifting foci of hematopoiesis during reconstitution from single stem cellsQ35122188
Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targetsQ35158939
In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsetsQ35847952
Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host diseaseQ36357597
CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.Q36362981
Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host diseaseQ36368026
Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector FunctionQ36371748
Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cellsQ36384673
Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activityQ36447926
NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axisQ37102921
TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donorsQ37291642
Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host diseaseQ37388077
IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generationQ37484523
Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.Q41005207
Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reactionQ41262864
A role for interleukin-1 alpha in immunologically mediated intestinal pathologyQ41531167
Recent advances in graft-versus-host disease (GVHD) preventionQ41561701
Nitric oxide mediates intestinal pathology in graft-vs.-host diseaseQ41609720
Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host diseaseQ41640832
Engineered regulatory T cells prevent graft-versus-host disease while sparing the graft-versus-leukemia effect after bone marrow transplantationQ43494585
Host-residual invariant NK T cells attenuate graft-versus-host immunityQ43515226
Superagonist CD28 antibody preferentially expanded Foxp3-expressing nTreg cells and prevented graft-versus-host diseasesQ44111698
Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imagingQ44189640
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantationQ44408941
Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanismQ46763980
Donor bone marrow type II (non-Valpha14Jalpha18 CD1d-restricted) NKT cells suppress graft-versus-host disease by producing IFN-gamma and IL-4.Q53518152
In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation.Q53589050
Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1.Q54567155
Stimulation of Host NKT Cells by Synthetic Glycolipid Regulates Acute Graft-versus-Host Disease by Inducing Th2 Polarization of Donor T CellsQ63363303
Close correlation between Daudi and mycobacterial antigen recognition by human gamma delta T cells and expression of V9JPC1 gamma/V2DJC delta-encoded T cell receptorsQ70466597
NK1.1+ CD4+ CD8- thymocytes with specific lymphokine secretionQ70527039
Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host diseaseQ71809477
Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host diseaseQ71870327
Differential cytokine production associated with distinct phases of murine graft-versus-host reactionQ72720440
Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated miceQ72776658
Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathwaysQ73850509
Differential effects of anti-Fas ligand and anti-tumor necrosis factor alpha antibodies on acute graft-versus-host disease pathologiesQ74576875
Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal deletionQ78488955
Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remissionQ78961005
Protective conditioning for acute graft-versus-host diseaseQ81279975
[Combination of dexamethasone with IL-2 selectively induces the expansion of CD4(+)CD25(+)FOXP3(+) regulatory T cells in vivo and suppresses graft versus host disease.].Q82807806
Graft-versus-host diseaseQ83468020
Adoptive therapy by transfusing expanded donor murine natural killer T cells can suppress acute graft-versus-host disease in allogeneic bone marrow transplantationQ84595134
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)3220-3229
P577publication date2011-01-21
P1433published inBloodQ885070
P1476titleLow doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism
P478volume117