Impaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1).

scientific article published on 24 January 2012

Impaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1). is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.341958
P932PMC publication ID3318699
P698PubMed publication ID22275377

P2093author name stringDavid Goltzman
Lucie Canaff
Geoffrey N Hendy
Hiroshi Kaji
Jean-François Vanbellinghen
P2860cites workMenin interacts with the AP1 transcription factor JunD and represses JunD-activated transcriptionQ22001458
Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signalingQ24290996
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivationQ24291618
Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2Q24293576
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expressionQ24297027
Menin, the product of the MEN1 gene, is a nuclear proteinQ24310070
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locusQ24313196
Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunDQ24316533
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitorsQ24337658
ModBase, a database of annotated comparative protein structure models, and associated resourcesQ24613729
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) proteinQ27670797
ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acidsQ27860850
Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1Q28243243
Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the geneQ28249576
Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lungQ28253904
Positional cloning of the gene for multiple endocrine neoplasia-type 1Q28307577
Characterization of the mouse Men1 gene and its expression during developmentQ28505998
Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4cQ28506197
Menin is required in cranial neural crest for palatogenesis and perinatal viabilityQ28513298
Activin inhibits pituitary prolactin expression and cell growth through Smads, Pit-1 and meninQ28564414
Cell cycle regulation of menin expressionQ28582170
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumorsQ28592210
Comparative protein structure modeling using ModellerQ29615142
Menin represses JunD-activated transcription by a histone deacetylase-dependent mechanismQ30779195
Differential binding of the Menin tumor suppressor protein to JunD isoforms.Q32061489
Autosomal recessive juvenile parkinsonism maps to 6q25.2-q27 in four ethnic groups: detailed genetic mapping of the linked regionQ34386289
The logic of TGFbeta signaling.Q34522372
Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8.Q34612025
Parathyroid tumor development involves deregulation of homeobox genesQ35098325
Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathwayQ35663471
Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoterQ35978041
Hereditary hormone excess: genes, molecular pathways, and syndromesQ35999772
Menin and TGF-beta superfamily member signaling via the Smad pathway in pituitary, parathyroid and osteoblastQ36185316
Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.Q36615929
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspectiveQ37347306
Cellular functions of menin.Q37696452
Role of menin in bone developmentQ39736696
Menin expression modulates mesenchymal cell commitment to the myogenic and osteogenic lineagesQ39847891
Activity and function of the nuclear factor kappaB pathway in human parathyroid tumors.Q42487214
Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras.Q42801463
Global expression profiling of sex cord stromal tumors from Men1 heterozygous mice identifies altered TGF-beta signaling, decreased Gata6 and increased Csf1r expressionQ44980967
Menin inactivation leads to loss of transforming growth factor beta inhibition of parathyroid cell proliferation and parathyroid hormone secretionQ47937066
Menin missense mutants encoded by the MEN1 gene that are targeted to the proteasome: restoration of expression and activity by CHIP siRNA.Q51544455
Expression and functional analysis of menin in a multiple endocrine neoplasia type 1 (MEN1) patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 gene.Q51788318
Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs.Q52550786
Clinical features of multiple endocrine neoplasia type 1 (MEN1) phenocopy without germline MEN1 gene mutations: analysis of 20 Japanese sporadic cases with MEN1.Q53914105
Multiple endocrine neoplasia type 1 (MEN1) gene mutations in a subset of patients with sporadic and familial primary hyperparathyroidism target the coding sequence but spare the promoter region.Q54471962
Deregulation of anti-Mullerian hormone/BMP and transforming growth factor-beta pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice.Q54544183
Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory.Q54680442
Mouse embryo fibroblasts lacking the tumor suppressor menin show altered expression of extracellular matrix protein genes.Q54739178
Mutation Analysis of the MEN1 Gene in Multiple Endocrine Neoplasia Type 1, Familial Acromegaly and Familial Isolated HyperparathyroidismQ57423374
Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidismQ58862086
Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1Q73557853
Internally shortened menin protein as a consequence of alternative RNA splicing due to a germline deletion in the multiple endocrine neoplasia type 1 geneQ73794693
Thymic carcinoids in multiple endocrine neoplasia type 1Q74791955
Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseasesQ77794377
Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complexQ79166838
Multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas in JapanQ81828264
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmultiple endocrine neoplasiaQ1553018
multiple endocrine neoplasia type 1Q3347154
P304page(s)8584-8597
P577publication date2012-01-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleImpaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1).
P478volume287

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cites work (P2860)
Q35111480Bilateral granulosa cell tumors: a novel malignant manifestation of multiple endocrine neoplasia 1 syndrome found in a patient with a rare menin in-frame deletion
Q49957735Current and emerging therapies for PNETs in patients with or without MEN1.
Q47948643Epigenetic regulation by the menin pathway
Q64964682Evolution of Our Understanding of the Hyperparathyroid Syndromes: A Historical Perspective.
Q37619445Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma
Q50290116MEN1 binds SMAD2/3:SMAD4 heterotrimer
Q28266645Novel MEN 1 gene findings in rare sporadic insulinoma--a case control study
Q40977644Novel association of MEN1 gene mutations with parathyroid carcinoma.
Q45316767SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Q97887355Unusual Combination of MEN-1 and the Contiguous Gene Deletion Syndrome of CAH and Ehlers-Danlos Syndrome (CAH-X)

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