Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination

scientific article published in February 1996

Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1476-5381.1996.TB15221.X
P932PMC publication ID1909313
P698PubMed publication ID8821543
P5875ResearchGate publication ID14382889

P2093author name stringThompson SA
Wafford KA
Whiting PJ
P2860cites workCloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human [...]Q24316082
Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptorsQ24322955
Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neuronsQ24616501
Molecular and cellular mechanisms of general anaesthesiaQ34291163
Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neuronesQ35756774
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalonQ38330309
The effects of general anaesthetics on GABAergic synaptic transmissionQ39463817
Potentiation of the effects of GABA by pentobarbitoneQ40244040
Functional domains of GABAA receptors.Q40453946
Allosteric modulations of the nicotinic acetylcholine receptor.Q40487666
The role of the GABAA receptor/chloride channel complex in anesthesia.Q40852807
General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of intracellular calciumQ41086586
Barbiturate enhancement of GABA-mediated inhibition and activation of chloride ion conductance: correlation with anticonvulsant and anesthetic actionsQ41550313
The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activationQ41570882
Modulation of the GABAA receptor by depressant barbiturates and pregnane steroidsQ41865800
A novel allosteric modulatory site on the GABAA receptor beta subunitQ42285400
Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in cultureQ43652740
gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channelQ48285707
Molecular Determinants of General Anesthetic Action: Role of GABAA Receptor StructureQ48317942
Actions of pentobarbital on rat brain receptors expressed in Xenopus oocytes.Q48318700
Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-familyQ48341437
Differential subcellular distribution of the alpha 6 subunit versus the alpha 1 and beta 2/3 subunits of the GABAA/benzodiazepine receptor complex in granule cells of the cerebellar cortexQ48403002
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum.Q48524991
Effects of two volatile anesthetics and a volatile convulsant on the excitatory and inhibitory amino acid responses in dissociated CNS neurons of the ratQ48621075
The effect of subunit composition of rat brain GABAA receptors on channel functionQ48875490
Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbitalQ49066197
Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.Q49082328
GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbitalQ49124909
Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptorsQ49138038
Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.Q49154995
Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons.Q51617593
Potentiation of gamma-aminobutyric acidA receptor Cl- current correlates with in vivo anesthetic potency.Q51626396
Benzodiazepine and beta-carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture.Q51640586
Propofol activates GABAA receptor-chloride ionophore complex in dissociated hippocampal pyramidal neurons of the rat.Q51654860
The effects of pentobarbital and related compounds on frog motoneuronsQ51875846
A second pathway of activation of the Torpedo acetylcholine receptor channelQ67700974
Kinetic properties of the pentobarbitone-gated chloride current in frog sensory neuronesQ68837946
BarbituratesQ69048105
(-)Pentobarbital opens ion channels of long duration in cultured mouse spinal neuronsQ72857379
Single channel currents activated by gamma-aminobutyric acid, muscimol, and (-)-pentobarbital in cultured mouse spinal neuronsQ72936590
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)521-527
P577publication date1996-02-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleBarbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination
P478volume117

Reverse relations

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