A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention

scientific article published in May 1997

A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention is …
instance of (P31):
scholarly articleQ13442814

External links are
P932PMC publication ID191514
P698PubMed publication ID9094639

P50authorMichael BotchanQ31796149
P2093author name stringD S King
C W Lehman
P2860cites workThe Cln3-Cdc28 kinase complex of S. cerevisiae is regulated by proteolysis and phosphorylationQ24555691
Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA targetQ27642089
E5 open reading frame of bovine papillomavirus type 1 encodes a transforming geneQ28286988
Selective extraction of polyoma DNA from infected mouse cell culturesQ29547500
CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elementsQ29618195
Bovine papillomavirus type 1 E2 transcriptional regulators directly bind two cellular transcription factors, TFIID and TFIIBQ33292465
Bovine papilloma virus-transformed cells contain multiple E2 proteinsQ33638736
E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: transactivation is mediated by the conserved amino-terminal domainQ33831373
Bovine papillomavirus type 1 3' early region transformation and plasmid maintenance functionsQ33928568
Differential promoter utilization by the bovine papillomavirus in transformed cells and productively infected wart tissuesQ33929070
Separation of the transcriptional activation and replication functions of the bovine papillomavirus-1 E2 proteinQ33938516
Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: structural and functional analysis of new viral cDNAsQ35409389
Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activityQ35595257
Negative regulation of the bovine papillomavirus E5, E6, and E7 oncogenes by the viral E1 and E2 genes.Q35829913
Amino acids critical for the functions of the bovine papillomavirus type 1 E2 transactivatorQ35853131
Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication.Q35863067
Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading framesQ35921639
The carboxy-terminal domain shared by the bovine papillomavirus E2 transactivator and repressor proteins contains a specific DNA binding activityQ35977741
A dimer of BPV-1 E2 containing a protease resistant core interacts with its DNA targetQ35996171
Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains.Q36062136
Human papillomaviruses in the pathogenesis of anogenital cancerQ36413260
Bovine papillomavirus contains multiple transforming genesQ36422987
Importance of the bovine papillomavirus P2443 promoter in the regulation of E2 and E5 expressionQ36653942
Characterization of the cis elements involved in basal and E2-transactivated expression of the bovine papillomavirus P2443 promoterQ36680070
Isolation of human sequences that replicate autonomously in human cellsQ36767535
Open reading frames E6 and E7 of bovine papillomavirus type 1 are both required for full transformation of mouse C127 cellsQ36780194
Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activityQ36801595
Phenotypic analysis of bovine papillomavirus type 1 E2 repressor mutantsQ36801624
The E2 transactivator of bovine papillomavirus type 1 is expressed from multiple promoters.Q36812512
Bovine papillomavirus with a mutation in the E2 serine 301 phosphorylation site replicates at a high copy number.Q36827979
Multiple EBNA1-binding sites are required to form an EBNA1-dependent enhancer and to activate a minimal replicative origin within oriP of Epstein-Barr virus.Q36828339
Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16Q36829187
Genetic assignment of multiple E2 gene products in bovine papillomavirus-transformed cellsQ36829530
Phosphorylation sites of the E2 transcriptional regulatory proteins of bovine papillomavirus type 1.Q36832051
Nonsense mutation in open reading frame E2 of bovine papillomavirus DNA.Q36857407
Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming geneQ36872874
Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitroQ37153499
Affinity purification of sequence-specific DNA binding proteinsQ37394403
Formation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1Q37552745
PEST sequences are signals for rapid intracellular proteolysisQ37805461
Regulation of early gene expression from the bovine papillomavirus genome in transiently transfected C127 cellsQ38332780
Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator.Q38362924
Cotranslational processing and protein turnover in eukaryotic cellsQ39566315
Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteinsQ40309052
Cellular control of human papillomavirus oncogene transcriptionQ40679147
Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.Q40790236
Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure.Q40790439
Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasiaQ40854169
Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcriptionQ41684614
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kineticsQ42163759
Activation of BPV-1 replication in vitro by the transcription factor E2.Q43594856
Amino acids necessary for DNA contact and dimerization imply novel motifs in the papillomavirus E2 trans-activatorQ44493539
Characterization of the bovine papilloma virus plasmid maintenance sequencesQ45797228
Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virusQ45803202
A quantitative in vitro focus assay for bovine papilloma virusQ45803536
Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genomeQ46082446
Transcription Factor E2 Regulates BPV-1 DNA Replication In Vitro by Direct Protein-Protein InteractionQ46086970
The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide.Q54144933
Dissociation of transforming and trans-activation functions for bovine papillomavirus type 1.Q54151145
Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.Q54723898
Genetic analysis of the 3' early region transformation and replication functions of bovine papillomavirus type 1.Q64956444
An improved procedure for identifying and quantitating protein phosphatases in mammalian tissuesQ69353149
Luciferase reporter gene vectors for analysis of promoters and enhancersQ69933226
Electrospray mass spectrometry for protein characterizationQ71948244
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)3652-3665
P577publication date1997-05-01
P1433published inJournal of VirologyQ1251128
P1476titleA papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention
P478volume71

Reverse relations

cites work (P2860)
Q39244725Acetylation of conserved lysines in bovine papillomavirus E2 by p300.
Q33961239Alleviation of human papillomavirus E2-mediated transcriptional repression via formation of a TATA binding protein (or TFIID)-TFIIB-RNA polymerase II-TFIIF preinitiation complex
Q35139675Characterization of the functional activities of the bovine papillomavirus type 1 E2 protein single-chain heterodimers
Q33782324Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control.
Q34334745E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes
Q37010544High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein
Q33806808Proteasome-mediated degradation of the papillomavirus E2-TA protein is regulated by phosphorylation and can modulate viral genome copy number
Q39696990Reconstitution of Epstein-Barr virus-based plasmid partitioning in budding yeast
Q34648403Regulation of the EBNA1 Epstein-Barr virus protein by serine phosphorylation and arginine methylation
Q34467994Replication and transcription of human papillomavirus type 58 genome in Saccharomyces cerevisiae
Q36471992Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation
Q39606345Stability of the human papillomavirus type 18 E2 protein is regulated by a proteasome degradation pathway through its amino-terminal transactivation domain
Q36185004Stability without a centromere
Q42011340Tax1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability
Q39588185The E8E2C protein, a negative regulator of viral transcription and replication, is required for extrachromosomal maintenance of human papillomavirus type 31 in keratinocytes
Q37198619The papillomavirus E2 proteins
Q39806563Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle.

Search more.