Structure, function and regulation of gonadotropin receptors - a perspective

scientific article published on 9 February 2012

Structure, function and regulation of gonadotropin receptors - a perspective is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MCE.2012.01.021
P932PMC publication ID3327826
P698PubMed publication ID22342845
P5875ResearchGate publication ID221840409

P2093author name stringK M J Menon
Bindu Menon
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A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activationQ80057802
Ribonucleic acid binding protein-mediated regulation of luteinizing hormone receptor expression in granulosa cells: relationship to sterol metabolismQ80433210
A novel mechanism for the modulation of luteinizing hormone receptor mRNA expression in the rat ovaryQ81521345
The role of luteinizing hormone/human chorionic gonadotropin receptor-specific mRNA binding protein in regulating receptor expression in human ovarian granulosa cellsQ82902378
Ovarian hyperstimulation syndrome (OHSS) due to mutations in the follicle-stimulating hormone receptorQ83983892
A splice site mutation combined with a novel missense mutation of LHCGR cause male pseudohermaphroditismQ84119001
Lactate dehydrogenase is an AU-rich element-binding protein that directly interacts with AUF1Q24301095
Structure of human follicle-stimulating hormone in complex with its receptorQ24338640
Crystal structure of human chorionic gonadotropinQ27731417
Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptorQ28184199
Autosomal dominant retinitis pigmentosa: a novel mutation at the peripherin/RDS locus in the original 6p-linked pedigreeQ28201915
The lutropin/choriogonadotropin receptor, a 2002 perspectiveQ28214215
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Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactionsQ28286455
Control of c-myc mRNA half-life in vitro by a protein capable of binding to a coding region stability determinantQ28298090
A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious pubertyQ28298512
A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious pubertyQ28299821
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Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovariesQ28570225
Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systemsQ28574084
Regulation of luteinizing hormone receptor expression: evidence of translational suppression in vitro by a hormonally regulated mRNA-binding protein and its endogenous association with luteinizing hormone receptor mRNA in the ovaryQ28577784
Isolation and characterization of a novel trans-factor for luteinizing hormone receptor mRNA from ovaryQ28909736
Identification of a hormonally regulated luteinizing hormone/human chorionic gonadotropin receptor mRNA binding protein. Increased mrna binding during receptor down-regulationQ28909832
The Lutropin/Choriogonadotropin Receptor, A 2002 PerspectiveQ29030892
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mRNA stability in mammalian cellsQ29616374
Interrelationships of the pathways of mRNA decay and translation in eukaryotic cellsQ29620524
A Novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure.Q30329947
Molecular, structural, and cellular biology of follitropin and follitropin receptor.Q30329979
Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAsQ33563194
Identification of constitutively activating mutation of the luteinising hormone receptor in a family with male limited gonadotrophin independent precocious puberty (testotoxicosis).Q33677126
Naturally occurring mutations of the luteinizing-hormone receptor: lessons learned about reproductive physiology and G protein-coupled receptors.Q33732533
Palmitoylation of luteinizing hormone/human choriogonadotropin receptors in transfected cells. Abolition of palmitoylation by mutation of Cys-621 and Cys-622 residues in the cytoplasmic tail increases ligand-induced internalization of the receptor.Q38301517
Posttranslational modifications of the lutropin receptor: mass spectrometric analysisQ38312116
Evidence that human chorionic gonadotropin/luteinizing hormone receptor down-regulation involves decreased levels of receptor messenger ribonucleic acidQ38337289
Role of E box and initiator region in the expression of the rat follicle-stimulating hormone receptorQ38350290
On the structure of the luteinizing hormone/chorionic gonadotropin receptorQ38667654
Molecular aspects of hormone action in ovarian follicular development, ovulation, and luteinizationQ39644473
Role of cyclic AMP in reproductive processesQ39902005
The role of cyclic AMP in gonadal functionQ39960279
Receptor-mediated gonadotropin action in the ovary. Desensitization of gonadotropin binding sites, activation of adenosine 3‘:5‘-cyclic monophosphate-dependent protein kinase(s), and regulation of steroidogenesis in rat ovaryQ40231617
LH-Induced Desensitization of the Adenylyl Cyclase System in Ovarian FolliclesQ40242221
Evidence that palmitoylation of carboxyl terminus cysteine residues of the human luteinizing hormone receptor regulates postendocytic processingQ40493153
A splice variant of the human luteinizing hormone (LH) receptor modulates the expression of wild-type human LH receptorQ40576741
Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNA.Q40609122
The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesisQ40817426
Palmitoylation of the luteinizing hormone/human chorionic gonadotropin receptor regulates receptor interaction with the arrestin-mediated internalization pathwayQ40820929
Characterization of regulatory elements of ovine follicle-stimulating hormone (FSH) receptor gene: the role of E-box in the regulation of ovine FSHreceptor expressionQ40830970
Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptorQ40842829
Evidence that constitutively active luteinizing hormone/human chorionic gonadotropin receptors are rapidly internalizedQ40944280
Multiple promoter elements contribute to activity of the follicle-stimulating hormone receptor (FSHR) gene in testicular Sertoli cellsQ41002657
Mutation of individual serine residues in the C-terminal tail of the lutropin/choriogonadotropin receptor reveal distinct structural requirements for agonist-induced uncoupling and agonist-induced internalizationQ41026387
The agonist-induced phosphorylation of the rat follitropin receptor maps to the first and third intracellular loopsQ41051222
The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transductionQ41114096
Progressive cytoplasmic tail truncations of the lutropin-choriogonadotropin receptor prevent agonist- or phorbol ester-induced phosphorylation, impair agonist- or phorbol ester-induced desensitization, and enhance agonist-induced receptor down-regulQ41194543
Truncation of the C-terminal Tail of the Follitropin Receptor Does Not Impair the Agonist- or Phorbol Ester-induced Receptor Phosphorylation and UncouplingQ41272427
A nonsense mutation of the human luteinizing hormone receptor gene in Leydig cell hypoplasiaQ41320758
Expression of follicle stimulating hormone-receptor mRNA during gonadal developmentQ41347053
Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor functionQ41374865
The lutropin/choriogonadotropin receptor is palmitoylated at intracellular cysteine residuesQ41374884
Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold).Q41664529
Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decayQ41697404
Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge regionQ41746302
The role of the hydroxy amino acid in the triplet sequence Asn-Xaa-Thr(Ser) for the N-glycosylation step during glycoprotein biosynthesisQ41987279
A mutation in the first transmembrane domain of the lutropin receptor causes male precocious pubertyQ42450904
A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.Q42458064
A sporadic case of male-limited precocious puberty has the same constitutively activating point mutation in luteinizing hormone/choriogonadotropin receptor gene as familial casesQ42476757
Sequence-specific binding of a hormonally regulated mRNA binding protein to cytidine-rich sequences in the lutropin receptor open reading frameQ42615914
Comparative structural analysis of the binding domain of follicle stimulating hormone receptorQ42718380
Identification of sequences within the murine granulocyte-macrophage colony-stimulating factor mRNA 3'-untranslated region that mediate mRNA stabilization induced by mitogen treatment of EL-4 thymoma cellsQ42826667
Gonadotropin-induced up- and down-regulation of ovarian follicle-stimulating hormone (FSH) receptor gene expression in immature rats: effects of pregnant mare's serum gonadotropin, human chorionic gonadotropin, and recombinant FSH.Q43530957
Palmitoylation of the V2 vasopressin receptor carboxyl tail enhances beta-arrestin recruitment leading to efficient receptor endocytosis and ERK1/2 activationQ44538209
Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and InsigsQ45081451
Granulosa cell maturation in the rat: increased binding of human chorionic gonadotropin following treatment with follicle-stimulating hormone in vivoQ45151078
Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.Q45233493
Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loopQ46114864
A novel mutation in exon8 of the follicle-stimulating hormone receptor in a woman with primary amenorrheaQ46145071
Gonadotropin-induced up- and down-regulation of rat ovarian LH receptor message levels during follicular growth, ovulation and luteinizationQ46153123
Effect of estrogen on the expression of luteinizing hormone-human chorionic gonadotropin receptor messenger ribonucleic acid in cultured rat granulosa cellsQ46823950
Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomasQ46839521
Alternative splicing of the human luteal LH receptor during luteolysis and maternal recognition of pregnancyQ47414192
Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeatsQ47631068
Alternatively spliced mRNA transcripts encoding the extracellular domain of the FSH receptor gene. Expression in the mouse ovary during the ovulatory cycleQ48018413
Structure of the bovine follicle-stimulating hormone receptor complementary DNA and expression in bovine tissuesQ48078857
Characterization and relative abundance of alternatively spliced luteinizing hormone receptor messenger ribonucleic acid in the ovine ovaryQ48080764
Two different entities of spontaneous ovarian hyperstimulation in a woman with FSH receptor mutation.Q51572510
Expression and binding activity of luteinizing hormone/chorionic gonadotropin receptors in the primary corpus luteum during early pregnancy in the mare.Q52102215
Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling.Q52521935
Sequence differences between glycosylated and non-glycosylated Asn-X-Thr/Ser acceptor sites: implications for protein engineeringQ57381679
Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndromeQ57901634
Follitropin receptor down-regulation involves a cAMP-dependent post-transcriptional decrease of receptor mRNA expressionQ67709143
Hormonal regulation of luteinizing hormone/chorionic gonadotropin receptor mRNA in rat ovarian cells during follicular development and luteinizationQ68380623
Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAsQ69007341
Modulation of progesterone synthesis and cytochrome P450 levels in rat luteal cells during human chorionic gonadotropin-induced desensitized stateQ69830287
Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: functional implicationsQ70113511
Loss of lutropin/human choriogonadotropin receptor messenger ribonucleic acid during ligand-induced down-regulation occurs post transcriptionallyQ70526923
Expression of luteinizing hormone and chorionic gonadotropin receptor messenger ribonucleic acid in human corpora lutea during menstrual cycle and pregnancyQ72149789
In situ hybridization of luteinizing hormone/human chorionic gonadotropin receptor messenger ribonucleic acid during hormone-induced down-regulation and the subsequent recovery in rat corpus luteumQ72150171
Fluorescence studies of the location and membrane accessibility of the palmitoylation sites of rhodopsinQ72413355
Phosphorylation-independent desensitization of the luteinizing hormone/chorionic gonadotropin receptor in porcine follicular membranesQ72596312
Receptor mediated gonadotropin action in the ovary. Modulation of progesterone response in isolated rat ovarian cells by gonadotrophin, cholera enterotoxin and cyclic nucleotides: requirement for RNA and protein synthesisQ72626130
Gonadotropin-Binding Sites in the Rhesus Monkey Ovary: Role of the Vasculature in the Selective Distribution of Human Chorionic Gonadotropin to the Preovulatory Follicle*Q72898207
Phosphorylation of the lutropin/choriogonadotropin receptor facilitates uncoupling of the receptor from adenylyl cyclase and endocytosis of the bound hormoneQ73025589
A 20-nucleotide (A + U)-rich element of beta2-adrenergic receptor (beta2AR) mRNA mediates binding to beta2AR-binding protein and is obligate for agonist-induced destabilization of receptor mRNAQ73248342
Transcriptional and post-transcriptional regulation of FSH receptor in rat granulosa cells by cyclic AMP and activinQ73468093
HCG promotes proliferation of uterine leiomyomal cells more strongly than that of myometrial smooth muscle cells in vitroQ73822037
Male hypogonadism caused by homozygous deletion of exon 10 of the luteinizing hormone (LH) receptor: differential action of human chorionic gonadotropin and LHQ73892807
A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7Q74314599
Acute signaling by the LH receptor is independent of protein kinase C activationQ74490839
Human fetal nongonadal tissues contain human chorionic gonadotropin/luteinizing hormone receptorsQ75425222
Coordinated expression of splice variants for luteinizing hormone receptor messenger RNA during the development of bovine corpora luteaQ77124439
Regulation of the FSH Receptor in the OvaryQ77886153
Post-transcriptional regulation of luteinizing hormone receptor mRNA in the ovary by a novel mRNA-binding proteinQ77900474
The tale of follitropin receptor diversity: a recipe for fine tuning gonadal responses?Q79325619
Identification and in vitro characterization of follicle stimulating hormone (FSH) receptor variants associated with abnormal ovarian response to FSHQ33736105
MAPK3/1 (ERK1/2) in ovarian granulosa cells are essential for female fertility.Q33763053
Female mice expressing constitutively active mutants of FSH receptor present with a phenotype of premature follicle depletion and estrogen excessQ33775566
Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.Q33787617
Phosphodiesterases and cyclic nucleotide signaling in endocrine cellsQ33916994
Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea.Q34038977
Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.Q34065999
Functional differences of invariant and highly conserved residues in the extracellular domain of the glycoprotein hormone receptorsQ34251314
Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty.Q34550171
The USF proteins regulate transcription of the follicle-stimulating hormone receptor but are insufficient for cell-specific expressionQ34751347
Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in womenQ34917501
Activating mutations of the lutropin choriogonadotropin receptor in precocious pubertyQ34984484
Mutation analysis of the LH receptor gene in Leydig cell adenoma and hyperplasia and functional and biochemical studies of activating mutations of the LH receptor gene.Q35101820
Inherited mutation of the luteinizing hormone/choriogonadotropin receptor (LHCGR) in empty follicle syndromeQ35126936
The gonadotrophin receptors: insights from the cloning of their cDNAsQ35530430
Regulation of luteinizing hormone/human chorionic gonadotropin receptor expression: a perspectiveQ35605205
A molecular dissection of the glycoprotein hormone receptors.Q35683443
Extragonadal luteinizing hormone receptors in the reproductive tract of domestic animalsQ35823880
Ribosome loading, but not protein synthesis, is required for estrogen stabilization of Xenopus laevis vitellogenin mRNAQ35955683
Evidence for the role of gonadotropin hormones in the development of Alzheimer diseaseQ36050353
Luteinizing hormone receptor mRNA down-regulation is mediated through ERK-dependent induction of RNA binding proteinQ36067432
Gonadotropin receptors: role of post-translational modifications and post-transcriptional regulationQ36202097
An update of the pathophysiology of human gonadotrophin subunit and receptor gene mutations and polymorphismsQ36241045
Specificity and promiscuity of gonadotropin receptors.Q36241050
LH receptor gene mutations and polymorphisms: an overviewQ36618453
A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.Q36632470
The past, present and future of nongonadal LH/hCG actions in reproductive biology and medicineQ36768835
In vivo regulation of follicle-stimulating hormone receptor by the transcription factors upstream stimulatory factor 1 and upstream stimulatory factor 2 is cell specificQ36972708
Evidence for the association of luteinizing hormone receptor mRNA-binding protein with the translating ribosomes during receptor downregulationQ37394272
The hinge region: an important receptor component for GPHR function.Q37612572
Diseases associated with mutations of the human lutropin receptorQ37726424
Follicle stimulating hormone receptor mutations and reproductive disordersQ37726428
Functional Glycosylation Sites of the Rat Luteinizing Hormone Receptor Required for Ligand BindingQ38291467
Ontogeny of follicle-stimulating hormone receptor gene expression in the rat testis and ovaryQ38299246
P433issue1-2
P304page(s)88-97
P577publication date2012-02-09
P1433published inMolecular and Cellular EndocrinologyQ1573600
P1476titleStructure, function and regulation of gonadotropin receptors - a perspective
P478volume356

Reverse relations

cites work (P2860)
Q33897203"Been hit twice": a novel bi-allelic heterozygous mutation in LHCGR.
Q33897141A novel compound heterozygous mutation of the luteinizing hormone receptor -implications for fertility
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