CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts

scientific article published on 20 July 2015

CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.20150407
P932PMC publication ID4516796
P698PubMed publication ID26195726
P5875ResearchGate publication ID280241075

P50authorJosef PenningerQ1674391
Julia CharlesQ57966806
Jae Myun LeeQ59681521
Kwang Hwan ParkQ60981157
Jin Woo LeeQ64681744
P2093author name stringAnju Singh
Roland Baron
Sutada Lotinun
Jae-Hyuck Shim
Sankar Ghosh
Matthew B Greenblatt
Changchun Xiao
Jung-Min Kim
Hwanhee Oh
Dong Yeon Shin
Dorothy Hu
Ki-young Lee
P2860cites workValosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradationQ24291519
CSN controls NF-kappaB by deubiquitinylation of IkappaBalphaQ24298155
Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast couplingQ24319108
Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalphaQ24329214
RANK is essential for osteoclast and lymph node developmentQ24598872
Pathobiology of Paget's Disease of BoneQ26824476
Mos10 (Vps60) is required for normal filament maturation in Saccharomyces cerevisiaeQ27930298
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperoneQ27930650
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.Q27935265
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sortingQ27939994
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complexQ28115418
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesisQ28508530
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorptionQ28592760
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.Q29417073
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteinsQ29617399
Genetic regulation of osteoclast development and functionQ29617421
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing proteinQ29619232
c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeletonQ30010102
Juvenile paget's disease in an Iranian kindred with vitamin D deficiency and novel homozygous TNFRSF11B mutationQ30437591
Juvenile Paget's disease with heterozygous duplication within TNFRSF11A encoding RANKQ34307564
Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.Q34512953
Osteosarcoma in Paget's disease of boneQ34574123
Abnormal osteoclasts and bone marrow fibrosis in Paget's disease of the boneQ79366605
Recombinant osteoprotegerin for juvenile Paget's diseaseQ81148009
Pathogenesis and management of Paget's disease of bone.Q34795095
Role of NF-κB in the skeletonQ35347883
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of boneQ35552797
Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of boneQ35595884
Treatment of idiopathic hyperphosphatasia with intensive bisphosphonate therapyQ35739746
Paget disease of boneQ36029217
Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cellsQ36223256
Mechanisms of disease: genetics of Paget's disease of bone and related disordersQ36577488
Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formationQ37123948
TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblastsQ37181921
Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorptionQ37249047
TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formationQ37307155
Mechanisms of osteoclast-dependent bone formationQ37414413
The p97-UFD1L-NPL4 protein complex mediates cytokine-induced IκBα proteolysisQ37546931
Insights into the pathogenesis of Paget's diseaseQ37730913
Recent advances in p97/VCP/Cdc48 cellular functionsQ37904023
The multiple faces of valosin-containing protein-associated diseases: inclusion body myopathy with Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis.Q37926529
Shaping development with ESCRTsQ37970884
Paget's disease of bone: clinical features and treatment.Q39613756
Expression of vascular endothelial growth factors and their receptors during osteoblast differentiationQ40881030
Incidence and natural history of Paget's disease of bone in England and Wales.Q45137415
Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivoQ47446256
Transgenic expression of CSF-1 in CSF-1 receptor-expressing cells leads to macrophage activation, osteoporosis, and early death.Q48420792
Denosumab treatment for juvenile Paget's disease: results from two adult patients with osteoprotegerin deficiency ("Balkan" mutation in the TNFRSF11B gene).Q50355957
IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration.Q51328560
Osteoclast-derived complement component 3a stimulates osteoblast differentiation.Q53069661
Some unusual features of Paget's disease of boneQ55062854
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasisQ57675131
Differential Gene Expression in Cultured Osteoblasts and Bone Marrow Stromal Cells From Patients With Paget's Disease of BoneQ62129332
Transgenic mice that express Cre recombinase in osteoclastsQ62829586
Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in paget's diseaseQ63407797
Ultrastructural characteristics of osteoclasts in Paget's diseaseQ68709329
Leukemia inhibitory factor is mitogenic to osteoblastsQ73640200
Fragile bones and macrocraniumQ74258271
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)1283-1301
P577publication date2015-07-20
P1433published inJournal of Experimental MedicineQ3186912
P1476titleCHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts
P478volume212

Reverse relations

cites work (P2860)
Q43850672A rheostat tuning thymic selection
Q97423430Activating PIK3CA mutation promotes osteogenesis of bone marrow mesenchymal stem cells in macrodactyly
Q34544054Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins
Q64925962Deubiquitinating Enzymes and Bone Remodeling.
Q92383538Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease
Q59066621Discovery of a periosteal stem cell mediating intramembranous bone formation
Q57265483EphrinB2 Signalling in Osteoblast Differentiation, Bone Formation and Endochondral Ossification
Q47825435Fine-tuning of thymocyte development by ubiquitination-mediated stability control of the ESCRT protein CHMP5.
Q64068457Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer
Q52587851Human Genetics of Sclerosing Bone Disorders.
Q51308225Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice.
Q27312272Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts
Q89814227Ophiopogonin D promotes bone regeneration by stimulating CD31hi EMCNhi vessel formation
Q90056276Osteoclasts are not a source of SLIT3
Q47944184Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.
Q40182044Post-translational control of T cell development by the ESCRT protein CHMP5.
Q47678861The ESCRT protein CHMP5 escorts αβ T cells through positive selection.
Q91650493The Role of Bone-Derived Exosomes in Regulating Skeletal Metabolism and Extraosseous Diseases
Q92622339The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms
Q57818480USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis
Q38754621c-Jun N-Terminal Kinases (JNKs) Are Critical Mediators of Osteoblast Activity In Vivo

Search more.