Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes

scientific article published on 7 February 2012

Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00474.2011
P932PMC publication ID3330722
P698PubMed publication ID22318949

P50authorKelvin YenQ37373287
Charles V. MobbsQ37373310
Rory J. McCrimmonQ42317155
P2093author name stringFumiko Isoda
Robert Sherwin
Sergei Musatov
William Janssen
Linda Yang
Xiaoning Fan
Jason Mastaitis
Ambrose Dunn-Meynell
Barry Levin
Steven P Kleopoulos
P2860cites workCombined receptor antagonist stimulation of the hypothalamic-pituitary-adrenal axis test identifies impaired negative feedback sensitivity to cortisol in obese men.Q46164651
Acute induction of gene expression in brain and liver by insulin-induced hypoglycemiaQ46406511
Structure-function analysis of squirrel monkey FK506-binding protein 51, a potent inhibitor of glucocorticoid receptor activityQ46414806
Cortisol metabolism in the Bolivian squirrel monkey (Saimiri boliviensis boliviensis).Q48090588
Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgeneQ48526900
Serum adiponectin and leptin in a patient with Cushing's syndrome before and after adrenalectomyQ80100186
FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibitionQ24651519
Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expressionQ24793433
Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesityQ24805593
Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neuronsQ28570095
Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemiaQ28576797
Role of leptin in the neuroendocrine response to fastingQ29618866
Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouseQ33848311
Hypothalamic Responses to Fasting Indicate Metabolic Reprogramming Away from Glycolysis Toward Lipid OxidationQ34197870
Steroid resistance in the squirrel monkey: an old subject revisitedQ34282728
Obesity over the life courseQ35807839
Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.Q35844707
Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob miceQ38306704
Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor bindingQ40840835
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
P433issue8
P921main subjectobesityQ12174
P304page(s)E987-91
P577publication date2012-02-07
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleHypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes
P478volume302

Reverse relations

cites work (P2860)
Q34142685Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.
Q27328366Enhancement of stress resilience through histone deacetylase 6-mediated regulation of glucocorticoid receptor chaperone dynamics
Q38885066FK506 binding protein 51 integrates pathways of adaptation: FKBP51 shapes the reactivity to environmental change.
Q41640775FKBP51 Null Mice Are Resistant to Diet-Induced Obesity and the PPARγ Agonist Rosiglitazone.
Q51245699Gene expression profile following an oral unsaturated fat load in abdominal obese subjects.
Q92604748Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment
Q47329852The FKBP51 Glucocorticoid Receptor Co-Chaperone: Regulation, Function, and Implications in Health and Disease
Q48682440The prospect of FKBP51 as a drug target
Q30370012Western High-Fat Diet Consumption during Adolescence Increases Susceptibility to Traumatic Stress while Selectively Disrupting Hippocampal and Ventricular Volumes