Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis

scientific article published on 16 February 2012

Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1161/ATVBAHA.111.240622
P932PMC publication ID3331918
P698PubMed publication ID22345168
P5875ResearchGate publication ID221842624

P50authorLena Claesson-WelshQ4942989
Lena KjellénQ4958976
Johan KreugerQ89288413
Zsolt KaszaQ92931591
Katarina HolmbornQ132042170
Inger ErikssonQ132042178
Dorothe SpillmannQ33273541
Ola SöderbergQ39977684
Lars JakobssonQ42876435
P2093author name stringIrene Weibrecht
Makoto Hayashi
Jeffrey D Esko
Johan Heldin
Joseph R Bishop
Sébastien Le Jan
P2860cites workCrystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerizationQ24290400
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparinQ24290496
Expression of decorin by sprouting bovine aortic endothelial cells exhibiting angiogenesis in vitroQ43477661
Betaglycan inhibits TGF-beta signaling by preventing type I-type II receptor complex formation. Glycosaminoglycan modifications alter betaglycan functionQ43773219
Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assemblyQ44850723
Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groupsQ45023582
Heparin regulates vascular endothelial growth factor165-dependent mitogenic activity, tube formation, and its receptor phosphorylation of human endothelial cells. Comparison of the effects of heparin and modified heparinsQ46606789
Peripheral mural cell recruitment requires cell-autonomous heparan sulfate.Q47929508
NG2 proteoglycan promotes angiogenesis-dependent tumor growth in CNS by sequestering angiostatin.Q48648419
Decorin deficiency leads to impaired angiogenesis in injured mouse cornea.Q52767198
Decorin suppresses tumor cell-mediated angiogenesisQ61771867
Ligand binding and functional properties of betaglycan, a co-receptor of the transforming growth factor-beta superfamily. Specialized binding regions for transforming growth factor-beta and inhibin AQ73693211
Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1Q74077953
Nitrocellulose Filter Binding to Assess Binding of Glycosaminoglycans to ProteinsQ79210669
Heparan sulfate structure in mice with genetically modified heparan sulfate productionQ80413581
Heparan sulfate-protein interactions--a concept for drug design?Q80541064
Heparan sulfate in trans potentiates VEGFR-mediated angiogenesisQ83296438
PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle FateQ24683266
Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouseQ28512852
Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycanQ28568024
Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient miceQ28586958
Derivation of completely cell culture-derived mice from early-passage embryonic stem cellsQ29547491
Angiogenesis in life, disease and medicineQ29614539
Molecular regulation of angiogenesis and lymphangiogenesisQ29616150
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptorQ29616189
VEGF receptor signalling - in control of vascular functionQ29617256
PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouseQ30640991
Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycanQ34312222
The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptorQ34560678
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wallQ35967045
Structural basis for fibroblast growth factor receptor activationQ36111391
Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesisQ36119681
Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragilityQ36258506
Interactions between heparan sulfate and proteins: the concept of specificityQ36552851
Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.Q36798761
Building blood vessels--stem cell models in vascular biologyQ36834586
Decorin is a novel antagonistic ligand of the Met receptorQ37263981
Decorin and its galactosaminoglycan chain: extracellular regulator of cellular function?Q37272650
Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis.Q37494563
Pericytes and vessel maturation during tumor angiogenesis and metastasisQ37764322
Mice Deficient in Heparan Sulfate N-Deacetylase/N-Sulfotransferase 1Q37784303
The conformation and structure of GAGs: recent progress and perspectivesQ37787520
Heparin amplifies platelet-derived growth factor (PDGF)- BB-induced PDGF alpha -receptor but not PDGF beta -receptor tyrosine phosphorylation in heparan sulfate-deficient cells. Effects on signal transduction and biological responsesQ38290891
Expression of the mouse mastocytoma glucosaminyl N-deacetylase/ N-sulfotransferase in human kidney 293 cells results in increased N-sulfation of heparan sulfateQ41204799
Pericytes limit tumor cell metastasisQ41916240
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular developmentQ42276166
Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplastyQ42792245
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectheparan sulfate proteoglycansQ66589633
P304page(s)1255-1263
P577publication date2012-02-16
P1433published inArteriosclerosis, Thrombosis, and Vascular BiologyQ4797542
P1476titleFunctional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis
P478volume32

Reverse relations

cites work (P2860)
Q41200344A glycan-based approach to therapeutic angiogenesis
Q90417370Characterization of C. elegans Chondroitin Proteoglycans and Their Large Functional and Structural Heterogeneity; Evolutionary Aspects on Structural Differences Between Humans and the Nematode
Q38986588Complex influence of dermatan sulphate on breast cancer cells.
Q89124983Current and emerging therapies for corneal neovascularization
Q26797302Determinants of Glycosaminoglycan (GAG) Structure
Q91619817Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A
Q47402381Expanding the chondroitin glycoproteome of Caenorhabditis elegans
Q27011582Heparan Sulfate Biosynthesis Enzymes in Embryonic Stem Cell Biology
Q38050077Heparan sulfate biosynthesis: regulation and variability
Q38256873Heparan sulfate in the regulation of neural differentiation and glioma development
Q36433979Hepatocyte Heparan Sulfate Is Required for Adeno-Associated Virus 2 but Dispensable for Adenovirus 5 Liver Transduction In Vivo
Q34884277Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans
Q42587744MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase-1 (NDST1) reduces endothelial cell responsiveness to vascular endothelial growth factor A (VEGFA).
Q41002514NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length
Q37310560Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans
Q91638143Network Pharmacology-Based Strategy for Predicting Therapy Targets of Traditional Chinese Medicine Xihuang Pill on Liver Cancer
Q44433053Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer
Q28727414On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis
Q26823840Pathophysiology of heparan sulphate: many diseases, few drugs
Q58063397SLC10A7 mutations cause a skeletal dysplasia with amelogenesis imperfecta mediated by GAG biosynthesis defects
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Q35118601The involvement of proteoglycans in the human plasma prekallikrein interaction with the cell surface.
Q55222850The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.

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