Ethanol suppresses phagosomal adhesion maturation, Rac activation, and subsequent actin polymerization during FcγR-mediated phagocytosis

scientific article published on 13 February 2012

Ethanol suppresses phagosomal adhesion maturation, Rac activation, and subsequent actin polymerization during FcγR-mediated phagocytosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELLIMM.2012.02.002
P932PMC publication ID3334404
P698PubMed publication ID22381996
P5875ResearchGate publication ID221880712

P2093author name stringElizabeth J Kovacs
Luis Ramirez
Cory Deburghgraeve
Eva L Murdoch
John Karavitis
P2860cites workF-actin binding site masked by the intramolecular association of vinculin head and tail domainsQ24309102
The phagosome proteome: insight into phagosome functionsQ24674883
Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cellsQ28182582
Regulation of phagocytosis by Rho GTPasesQ28258511
TLR4, ethanol, and lipid rafts: a new mechanism of ethanol action with implications for other receptor-mediated effectsQ28284163
The coordination of signaling during Fc receptor-mediated phagocytosisQ28286273
Fc receptors and their interactions with immunoglobulinsQ28299765
Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophageQ28577288
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPasesQ29614245
Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disordersQ29615543
Mechanisms of phagocytosis in macrophagesQ29618100
Acute ethanol exposure induces [Ca2+]i transients, cell swelling and transformation of actin cytoskeleton in astroglial primary culturesQ32034853
Modular components of phagocytosis.Q33782000
Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages.Q33877279
Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3.Q33899706
Phagocytosis and the actin cytoskeleton.Q33936057
Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by MacrophagesQ34021981
RhoA and lysophosphatidic acid are involved in the actin cytoskeleton reorganization of astrocytes exposed to ethanolQ34191740
Acute ethanol exposure attenuates pattern recognition receptor activated macrophage functionsQ34328859
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model systemQ34439283
Rho GTPases and the control of cell behaviourQ34462373
Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunctionQ35101941
Roles of Rho-family GTPases in cell polarisation and directional migrationQ35547373
Strategic targets of essential host-pathogen interactionsQ36064617
Genetic polymorphisms in sepsisQ36109267
Alcohol abuse and acute lung injury: epidemiology and pathophysiology of a recently recognized associationQ36206786
Phagocytosis: at the crossroads of innate and adaptive immunityQ36280350
Alcohol, immunosuppression, and the lungQ36328690
The effects of alcohol on immunity and bacterial infection in the lungQ36368713
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytesQ36380848
Exposure-dependent effects of ethanol on the innate immune systemQ36755709
Intercellular spread of Shigella flexneri through a monolayer mediated by membranous protrusions and associated with reorganization of the cytoskeletal protein vinculinQ36987733
Cytochalasin B reversibly inhibits phagocytosis: functional, metabolic, and ultrastructural effects in human blood leukocytes and rabbit alveolar macrophagesQ36991610
The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytesQ37354457
Vav regulates activation of Rac but not Cdc42 during FcgammaR-mediated phagocytosisQ39540613
Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsisQ40121684
Ethanol suppresses LPS-induced Toll-like receptor 4 clustering, reorganization of the actin cytoskeleton, and associated TNF-alpha productionQ40245495
Chronic ethanol increases lipopolysaccharide-stimulated Egr-1 expression in RAW 264.7 macrophages: contribution to enhanced tumor necrosis factor alpha productionQ40749420
The IgG Fc receptor familyQ40847754
Membrane recruitment of Rac1 triggers phagocytosisQ40863099
Fc receptor-mediated phagocytosis requires CDC42 and Rac1.Q40997595
Mechanisms of phagocytosisQ41053690
Inhibition of phagocytosis and plasma membrane mobility of the cultivated macrophage by cytochalasin B. Role of subplasmalemmal microfilamentsQ41182472
Fc receptor biologyQ41464279
FcgammaR-mediated phagocytosis by human macrophages involves Hck, Syk, and Pyk2 and is augmented by GM-CSF.Q43700282
Clinical relevance of TLR2, TLR4, CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection.Q43878196
The phagosomal proteome in interferon-gamma-activated macrophagesQ43931481
Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK.Q44666485
Serum alcohol concentrations in trauma patients determined by immunoassay versus gas chromatographyQ44700944
Three-dimensional structure of vinculin bound to actin filamentsQ44718700
In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activationQ45195947
Different effects of acute and chronic ethanol on LPS-induced cytokine production and TLR4 receptor behavior in mouse peritoneal macrophagesQ46287406
The role of Rac1 and Rac2 in bacterial killingQ46698753
The RhoA/ROCK-I/MLC pathway is involved in the ethanol-induced apoptosis by anoikis in astrocytesQ46877821
Acute ethanol treatment modulates Toll-like receptor-4 association with lipid raftsQ46909234
Acute ethanol administration modulates leukocyte actin polymerization in endotoxic rats.Q50939548
Latrunculin A is a potent inhibitor of phagocytosis by macrophages.Q52491200
Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.Q54762133
In vitro effects of ethanol on the phagocytic and microbial killing activities of normal human blood monocytes and monocyte-derived macrophagesQ68212845
Effects of ethanol and acetaldehyde on phagocytic functionsQ70082936
Effects of cytochalasin B on polymorphonuclear leucocyte locomotion, phagocytosis and glycolysisQ70439654
The effects of alcohol on murine macrophage functionQ70683596
Reduced Fc-receptor function in human monocytes exposed to ethanol in vitroQ70702726
The effect of ethanol on adherence and phagocytosis by rabbit alveolar macrophagesQ71214497
Monocytes, alcohol use, and altered immunityQ77198970
Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formationQ77342941
Continuity between wound macrophage and fibroblast phenotype: analysis of wound fibroblast phagocytosisQ77358888
Alcohol abuse, alcoholism, and damage to the immune system--a reviewQ77780693
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectphagocytosisQ184726
P1104number of pages11
P304page(s)61-71
P577publication date2012-02-13
P1433published inCellular ImmunologyQ2597167
P1476titleEthanol suppresses phagosomal adhesion maturation, Rac activation, and subsequent actin polymerization during FcγR-mediated phagocytosis
P478volume274

Reverse relations

cites work (P2860)
Q35039859Acute immunomodulatory effects of binge alcohol ingestion
Q30243990Alcohol and lung injury and immunity
Q40424620Alcohol exposure differentially effects anti-tumor immunity in females by altering dendritic cell function
Q37713144Alcohol impairs J774.16 macrophage-like cell antimicrobial functions in Acinetobacter baumannii infection
Q42277301Aliphatic alcohol contaminants of illegally produced spirits inhibit phagocytosis by human granulocytes.
Q92279955Compounding effect of vitamin D3 diet, supplementation, and alcohol exposure on macrophage response to mycobacterium infection
Q88916044Effects of Multiday Ethanol Intoxication on Postburn Inflammation, Lung Function, and Alveolar Macrophage Phenotype
Q28551627Ethanol Inhibits High-Affinity Immunoglobulin E Receptor (FcεRI) Signaling in Mast Cells by Suppressing the Function of FcεRI-Cholesterol Signalosome
Q38757965Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation
Q39483377Ethanol intoxication prolongs post-burn pulmonary inflammation: role of alveolar macrophages
Q36258019Impaired respiratory function and heightened pulmonary inflammation in episodic binge ethanol intoxication and burn injury
Q90227080Methamphetamine Impairs IgG1-Mediated Phagocytosis and Killing of Cryptococcus neoformans by J774.16 Macrophage- and NR-9640 Microglia-Like Cells
Q36419227MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages.
Q55513242Overexpression of Toll-like Receptor 4-linked Mitogen-activated Protein Kinase Signaling Contributes to Internalization of Escherichia coli in Sheep.
Q34403131P2X4 receptor regulates alcohol-induced responses in microglia
Q36586146Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age.
Q42728681Relative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression
Q55223069Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.

Search more.