Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait

scientific article published on 10 February 2012

Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2011-08-371062
P932PMC publication ID3335384
P698PubMed publication ID22327223
P5875ResearchGate publication ID221825665

P50authorChris J DrakeleyQ56774786
Catherine Maiteki-SebuguziQ59669696
Grant DorseyQ60029509
Philip J RosenthalQ60060211
Bryan GreenhouseQ37383090
P2093author name stringAlan E Hubbard
Lauren Gong
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Hemoglobin C and resistance to severe malaria in Ghanaian childrenQ39257155
Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malariaQ40913951
Sickling Rates of Human as Red Cells Infected in Vitro with Plasmodium falciparum MalariaQ40949343
Pyrimethamine and Proguanil Resistance-Conferring Mutations in Plasmodium falciparum Dihydrofolate Reductase: Polymerase Chain Reaction Methods for Surveillance in AfricaQ41933010
Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infectionQ44147641
Variation of Plasmodium falciparum msp1 block 2 and msp2 allele prevalence and of infection complexity in two neighbouring Senegalese villages with different transmission conditionsQ46340041
Modulation of the cellular immune response during Plasmodium falciparum infections in sickle cell trait individualsQ46782894
Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum-parasitized erythrocytes: a role for CD36 in malarial clearance.Q47873176
Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptorQ47888299
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Increased sickling of parasitised erythrocytes as mechanism of resistance against malaria in the sickle-cell traitQ47934937
Influence of haemoglobins S and C on predominantly asymptomatic Plasmodium infections in northern GhanaQ47952896
Plasmodium falciparum malaria and human red cells. II. Red cell genetic traits and resistance against malariaQ47991305
An immune basis for malaria protection by the sickle cell traitQ21144724
Genome-wide and fine-resolution association analysis of malaria in West AfricaQ24632119
Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseasesQ24632966
Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesisQ24633916
Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobinQ24647452
Protection afforded by sickle-cell trait against subtertian malareal infectionQ24671995
Protective effects of the sickle cell gene against malaria morbidity and mortalityQ28215309
Common west African HLA antigens are associated with protection from severe malariaQ28288693
Sickle Hemoglobin Confers Tolerance to Plasmodium InfectionQ29038323
Longitudinal data analysis for discrete and continuous outcomesQ29547235
Haemoglobin C and S role in acquired immunity against Plasmodium falciparum malariaQ33301333
Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan childrenQ33650896
Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia traitQ33980279
Sickle cell disease in the Balovale District of Northern RhodesiaQ34146536
Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobinQ34241897
Limited influence of haemoglobin variants on Plasmodium falciparum msp1 and msp2 alleles in symptomatic malariaQ34316472
Longitudinal study of urban malaria in a cohort of Ugandan children: description of study site, census and recruitmentQ34534151
The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiologyQ34542050
Hemoglobin variants and disease manifestations in severe falciparum malariaQ34630890
Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections.Q35219959
Immune responses to asexual blood-stages of malaria parasitesQ36412872
Imbalanced distribution of Plasmodium falciparum MSP-1 genotypes related to sickle-cell trait.Q36437782
Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malariaQ36953171
Malaria-induced lymphokines: stimulation of macrophages for enhanced phagocytosisQ37102564
Immunity to malaria: more questions than answersQ37194482
Erythrocytic mechanism of sickle cell resistance to malariaQ37584713
Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trialQ38397102
Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in UgandaQ38873068
Factors determining the heterogeneity of malaria incidence in children in Kampala, UgandaQ38876186
The sickle cell trait is associated with enhanced immunoglobulin G antibody responses to Plasmodium falciparum variant surface antigensQ38928381
Comparison of PCR-RFLP and Genescan-based genotyping for analyzing infection dynamics of Plasmodium falciparum.Q38998328
Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growthQ39148305
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectsickle-cell diseaseQ185034
Plasmodium falciparumQ311383
P1104number of pages7
P304page(s)3808-3814
P577publication date2012-02-10
P1433published inBloodQ885070
P1476titleEvidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait
P478volume119

Reverse relations

cites work (P2860)
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