Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor

scientific article published on 18 August 2011

Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S10549-011-1713-X
P932PMC publication ID4523065
P698PubMed publication ID21850397

P2093author name stringHua Zhang
Yan Zhang
Douglas Yee
Annabell Oh
Xianke Zeng
P2860cites workULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machineryQ24649645
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Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapyQ33934670
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Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetesQ34157626
Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptorQ34172489
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The Insulin-like Growth Factor I Receptor/Insulin Receptor Tyrosine Kinase Inhibitor PQIP Exhibits Enhanced Antitumor Effects in Combination with Chemotherapy Against Colorectal Cancer ModelsQ35058305
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Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: effect of the dual-receptor inhibitor BMS-536924 in vitroQ37389178
Autophagy in cellular growth controlQ37680207
Effect of type 1 insulin-like growth factor receptor targeted therapy on chemotherapy in human cancer and the mechanisms involvedQ37688986
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Insulin receptor isoform A and insulin-like growth factor II as additional treatment targets in human osteosarcoma.Q39877535
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A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.Q40616617
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Sequencing of tamoxifen and radiotherapy after breast-conserving surgery in early-stage breast cancerQ45151891
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer.Q45950196
Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumorsQ46972238
Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1Q81165876
Inhibition of HER-2 by three independent targeting strategies increases paclitaxel resistance of SKOV-3 ovarian carcinoma cellsQ81380006
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdoxorubicinQ18936
cytotoxicityQ246181
PQIPQ27162600
P304page(s)117-126
P577publication date2011-08-18
P1433published inBreast Cancer Research and TreatmentQ326085
P1476titleEnhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor
P478volume133

Reverse relations

cites work (P2860)
Q38772200A comprehensive pharmacokinetic/pharmacodynamics analysis of the novel IGF1R/INSR inhibitor BI 893923 applying in vitro, in vivo and in silico modeling techniques
Q37029389A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R) : implications for inhibition of the IGF-1R signal
Q35837734A tale of two receptors: insulin and insulin-like growth factor signaling in cancer
Q34336988Can we unlock the potential of IGF-1R inhibition in cancer therapy?
Q36545498IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide
Q34391968Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer.
Q36790586Insulin-like growth factor receptor inhibitors: baby or the bathwater?
Q35136532Lipid Signaling in Tumorigenesis
Q36615766Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors
Q44636888Relevance of insulin-like growth factor 1 receptor gene expression as a prognostic factor in non-small-cell lung cancer.
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Q36708178Targeting the insulin-like growth factor-1 receptor in human cancer
Q35609517The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link
Q26852910The links between insulin resistance, diabetes, and cancer

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