Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3.

scientific article published in November 1996

Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID452323
P698PubMed publication ID8918453

P2093author name stringJ L Degen
K Holmbäck
M J Danton
C C Daugherty
T T Suh
P2860cites workInitiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factorQ24317407
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte developmentQ24321429
Gsh-4 encodes a LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survivalQ24595086
Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolinQ28300043
HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cellsQ28511588
Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptorsQ28645681
Platelets have more than one binding site for von Willebrand factorQ33821754
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectinQ34056920
Lamprey fibrinogen gamma chain: cloning, cDNA sequencing, and general characterizationQ35588652
Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated plateletsQ36232933
Site-directed mutagenesis of the arginine-glycine-aspartic acid in vitronectin abolishes cell adhesionQ36695804
Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptorQ36772797
Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulationQ37511530
The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to plateletsQ37556824
Glanzmann's thrombasthenia: the spectrum of clinical diseaseQ37909047
Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesisQ38330466
Adhesive signaling in plateletsQ40396958
Binding of recombinant fibrinogen mutants to plateletsQ41495114
Characterization of the gamma chain platelet binding site on fibrinogen fragment DQ42139757
Targeted disruption of the mouse factor VIII gene produces a model of haemophilia AQ45868121
Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIaQ46619536
Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells.Q46653870
Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated plateletsQ46861225
.gamma. and .gamma.' chains of human fibrinogen are produced by alternative mRNA processingQ48388090
Organization of the rat gamma-fibrinogen gene: alternative mRNA splice patterns produce the gamma A and gamma B (gamma ') chains of fibrinogenQ48402271
Clues for understanding the structure and function of a prototypic human integrin: the platelet glycoprotein IIb/IIIa complex.Q50695257
A pgk::hprt fusion as a selectable marker for targeting of genes in mouse embryonic stem cells: disruption of the T-cell receptor δ-chain-encoding geneQ52481250
Glycoprotein IIb/IIIa blockade inhibits platelet-mediated force development and reduces gel elastic modulus.Q52509289
Platelet-vessel wall interaction: from the bedside to molecules.Q53641231
Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complexQ67986716
Peptides and monoclonal antibodies which bind to platelet glycoproteins IIb and/or IIIa inhibit clot retractionQ68280443
Isolation of human fibrinogen and its derivatives by affinity chromatography on Gly-Pro-Arg-Pro-Lys-FractogelQ68923965
Localization of the domains of fibrin involved in binding to plateletsQ69816001
Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human plateletsQ69871824
Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectinQ69873043
The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated plateletsQ70101386
Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to plateletsQ70181883
Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the .gamma. chainQ70211601
Diversity of primary structures of the carboxy-terminal regions of mammalian fibrinogen A alpha-chains. Characterization of the partial nucleotide and deduced amino acid sequences in five mammalian species; rhesus monkey, pig, dog, mouse and SyrianQ70727248
Platelet integrinsQ70943448
Platelet adhesion to collagenQ70943503
The role of von Willebrand factor and fibrinogen in the initiation of platelet adhesion to thrombogenic surfacesQ70943506
Dissecting clot retraction and platelet aggregation. Clot retraction does not require an intact fibrinogen gamma chain C terminusQ71058629
Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient miceQ71995270
Plasminogen deficiency causes severe thrombosis but is compatible with development and reproductionQ72130896
Tyrosine kinases regulate the cytoskeletal attachment of integrin alpha IIb beta 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymersQ72352246
Role of actin in platelet functionQ72715775
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectplatelet aggregationQ14913634
P304page(s)5760-5771
P577publication date1996-11-01
P1433published inThe EMBO JournalQ1278554
P1476titleImpaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3.
P478volume15

Reverse relations

cites work (P2860)
Q28586884A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis
Q34685199Binding of Efb from Staphylococcus aureus to fibrinogen blocks neutrophil adherence.
Q35806023Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.
Q34889402Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen
Q64276058Epitope Mapping Immunoassay Analysis of the Interaction between β-Amyloid and Fibrinogen
Q36025268Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif
Q57116809Fibrinogen Hershey IV: a novel dysfibrinogen with a gammaV411I mutation in the integrin alpha(IIb)beta(3) binding site
Q64069650Fibrinogen and fibrin: An illustrated review
Q37950860Fibrinogen as a key regulator of inflammation in disease
Q52606339Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics.
Q36666780Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia
Q30591548Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo
Q30477630Plasma fibronectin promotes thrombus growth and stability in injured arterioles
Q34282877Platelet aggregation inhibition with glycoprotein IIb--IIIa inhibitors
Q30442042Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling
Q48262560Structural and functional aspects of decorsin and its analog as recognized by integrin αIIbβ3.
Q27651670Structural basis for distinctive recognition of fibrinogen γC peptide by the platelet integrin α IIb β 3
Q52584483The 95RGD97 sequence on the Aα chain of fibrinogen is essential for binding to its erythrocyte receptor.
Q28584694The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen
Q35921137The Platelet Integrin αIIbβ3 Differentially Interacts with Fibrin Versus Fibrinogen
Q35066799The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain
Q42961262The platelet integrin alphaIIbbeta3 binds to the RGD and AGD motifs in fibrinogen
Q38665177Thrombin promotes diet-induced obesity through fibrin-driven inflammation
Q91904115Yersinia pestis Pla Protein Thwarts T Cell Defense against Plague
Q35642870mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets.
Q36744522β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece

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