Melatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway.

scientific article published on 7 July 2015

Melatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JPI.12250
P932PMC publication ID4523475
P698PubMed publication ID25975679
P5875ResearchGate publication ID276295700

P50authorGuoqing PanQ39897171
P2093author name stringXi Chen
Tao Liu
Fan He
Huilin Yang
Zong-Ping Luo
Long Zhou
Ming Pei
Yihong Gong
Wenguo Cui
Sijin Chen
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Cell contact accelerates replicative senescence of human mesenchymal stem cells independent of telomere shortening and p53 activation: roles of Ras and oxidative stress.Q54625261
Identification of highly elevated levels of melatonin in bone marrow: its origin and significanceQ59489066
Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cellsQ63358368
SIRT1 is required for long-term growth of human mesenchymal stem cells.Q64928803
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Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblastsQ83045384
Melatonin Pretreatment Improves the Survival and Function of Transplanted Mesenchymal Stem Cells after Focal Cerebral IschemiaQ86699695
Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*Q22306227
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Ink4a/Arf expression is a biomarker of agingQ28570483
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Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, p38 and JNKQ33643130
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Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway.Q34237779
SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescenceQ34367932
Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expressionQ34403678
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporterQ34410957
Involvement of the INK4a/Arf gene locus in senescenceQ35185629
Human umbilical cord blood-derived mesenchymal stem cells undergo cellular senescence in response to oxidative stressQ36093174
Cell-penetrating superoxide dismutase attenuates oxidative stress-induced senescence by regulating the p53-p21(Cip1) pathway and restores osteoblastic differentiation in human dental pulp stem cellsQ36284052
Antioxidation of decellularized stem cell matrix promotes human synovium-derived stem cell-based chondrogenesis.Q36648920
Mesenchymal stem cells: lineage, plasticity, and skeletal therapeutic potentialQ36672124
H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline, in senescent human fetal mesenchymal stem cellsQ36760909
Promotion of hepatic differentiation of bone marrow mesenchymal stem cells on decellularized cell-deposited extracellular matrixQ37111100
Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometriumQ37156197
Cellular senescence: molecular mechanisms, in vivo significance, and redox considerationsQ37314233
A comprehensive review on mesenchymal stem cell growth and senescence.Q37465287
Senescence-associated intrinsic mechanisms of osteoblast dysfunctions.Q37826459
The therapeutic potential of bone marrow-derived stromal cellsQ37890316
Cell senescence: a challenge in cartilage engineering and regenerationQ37978376
On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK.Q38045452
Melatonin: a well-documented antioxidant with conditional pro-oxidant actionsQ38233680
Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16(INK4a.).Q38960490
Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cellsQ38984158
Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cellsQ39452092
Hydrogen peroxide induces G2 cell cycle arrest and inhibits cell proliferation in osteoblastsQ39818568
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmesenchymal stem cellQ1922379
P304page(s)190-205
P577publication date2015-07-07
P1433published inJournal of Pineal ResearchQ15056565
P1476titleMelatonin reverses H2 O2 -induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway
P478volume59

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cites work (P2860)
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